sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

Cross Reference

Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with sphingosylphosphorylcholine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

Download all related citations
Per page 10 20 50 100 | Total 248
Authors Title Published Journal PubMed Link
Seufferlein T and Rozengurt E Sphingosylphosphorylcholine rapidly induces tyrosine phosphorylation of p125FAK and paxillin, rearrangement of the actin cytoskeleton and focal contact assembly. Requirement of p21rho in the signaling pathway. 1995 J. Biol. Chem. pmid:7592646
Jeong HS et al. Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects. 2011 J. Biomed. Sci. pmid:21838918
Lyons JM and Karin NJ A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells. 2001 J. Bone Miner. Res. pmid:11697799
Kanazawa T et al. Inhibition of cytokinesis by a lipid metabolite, psychosine. 2000 J. Cell Biol. pmid:10811833
Desai NN et al. Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts. 1993 J. Cell Biol. pmid:8389770
Kostenis E Novel clusters of receptors for sphingosine-1-phosphate, sphingosylphosphorylcholine, and (lyso)-phosphatidic acid: new receptors for "old" ligands. 2004 J. Cell. Biochem. pmid:15258916
Jeon ES et al. Sphingosylphosphorylcholine induces apoptosis of endothelial cells through reactive oxygen species-mediated activation of ERK. 2007 J. Cell. Biochem. pmid:17131361
Ge D et al. Regulation of apoptosis and autophagy by sphingosylphosphorylcholine in vascular endothelial cells. 2011 J. Cell. Physiol. pmid:21302284
Xu Y et al. Effect of lysophospholipids on signaling in the human Jurkat T cell line. 1995 J. Cell. Physiol. pmid:7775587
Jeon ES et al. Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism. 2006 J. Cell. Sci. pmid:17105765
Busch T et al. Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells. 2012 J. Cell. Sci. pmid:22344252
Hyder CL et al. Sphingolipids inhibit vimentin-dependent cell migration. 2015 J. Cell. Sci. pmid:25908861
Wirrig C et al. Sphingosylphosphorylcholine is a proinflammatory mediator in cerebral arteries. 2011 J. Cereb. Blood Flow Metab. pmid:20551970
Shirao S et al. A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts. 2015 J. Cereb. Blood Flow Metab. pmid:25605290
Fujiwaki T et al. Quantitative evaluation of sphingolipids using delayed extraction matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to cardiac valves from a patient with Fabry disease. 2006 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:16431168
Fujiwaki T et al. Quantitative evaluation of sphingomyelin and glucosylceramide using matrix-assisted laser desorption ionization time-of-flight mass spectrometry with sphingosylphosphorylcholine as an internal standard. Practical application to tissues from patients with Niemann-Pick disease types A and C, and Gaucher disease. 2008 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:18502707
Imokawa G A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. 2009 J. Dermatol. Sci. pmid:19443184
Kim HJ et al. Sphingosylphosphorylcholine induces degranulation of mast cells in the skin and plasma exudation in the ears of mice. 2010 J. Dermatol. Sci. pmid:19889516
Kwon YB et al. Sphingosylphosphorylcholine-induced interleukin-6 production is mediated by protein kinase C and p42/44 extracellular signal-regulated kinase in human dermal fibroblasts. 2007 J. Dermatol. Sci. pmid:17321112
Lee HY et al. Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells. 2011 J. Immunol. pmid:21368227
Takenouchi T et al. Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway. 2008 J. Immunol. pmid:18523246
van Diggelen OP et al. A new fluorimetric enzyme assay for the diagnosis of Niemann-Pick A/B, with specificity of natural sphingomyelinase substrate. 2005 J. Inherit. Metab. Dis. pmid:16151905
Imokawa G et al. Sphingosylphosphorylcholine is a potent inducer of intercellular adhesion molecule-1 expression in human keratinocytes. 1999 J. Invest. Dermatol. pmid:9886270
Kye KC et al. Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts. 2004 J. Invest. Dermatol. pmid:15175025
Andoh T et al. Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin. 2009 J. Invest. Dermatol. pmid:19657356
Sun L et al. A new wound healing agent--sphingosylphosphorylcholine. 1996 J. Invest. Dermatol. pmid:8601721
Murata Y et al. Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? 1996 J. Invest. Dermatol. pmid:8752664
Wakita H et al. Sphingosylphosphorylcholine stimulates proliferation and upregulates cell surface-associated plasminogen activator activity in cultured human keratinocytes. 1998 J. Invest. Dermatol. pmid:9506444
Tokura Y et al. Modulation of T-lymphocyte proliferation by exogenous natural ceramides and sphingosylphosphorylcholine. 1999 J. Investig. Dermatol. Symp. Proc. pmid:10536997
Higuchi K et al. Sphingosylphosphorylcholine is an activator of transglutaminase activity in human keratinocytes. 2001 J. Lipid Res. pmid:11590211
Okamoto R et al. Sphingosylphosphorylcholine is upregulated in the stratum corneum of patients with atopic dermatitis. 2003 J. Lipid Res. pmid:12518027
Bittman R and Verbicky CA Methanolysis of sphingomyelin. Toward an epimerization-free methodology for the preparation of D-erythro-sphingosylphosphocholine. 2000 J. Lipid Res. pmid:11108743
Xin C et al. Sphingosylphosphorylcholine acts in an anti-inflammatory manner in renal mesangial cells by reducing interleukin-1beta-induced prostaglandin E2 formation. 2007 J. Lipid Res. pmid:17592175
Jeon ES et al. Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK. 2006 J. Lipid Res. pmid:16339111
Sripada PK et al. Partial synthesis and properties of a series of N-acyl sphingomyelins. 1987 J. Lipid Res. pmid:3611973
Sueyoshi N et al. Preparation of a naturally occurring D-erythro-(2S, 3R)-sphingosylphosphocholine using Shewanella alga NS-589. 1997 J. Lipid Res. pmid:9323602
Ignatov A et al. Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. 2003 J. Neurosci. pmid:12574419
Lu X and Bittman R Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue. 2005 J. Org. Chem. pmid:15932314
Aksu B et al. Effects of sphingosylphosphorylcholine against cholestatic oxidative stress and liver damage in the common bile duct ligated rats. 2009 J. Pediatr. Surg. pmid:19361629
Aksu B et al. Effects of sphingosylphosphorylcholine against oxidative stress and acute lung ınjury ınduced by pulmonary contusion in rats. 2015 J. Pediatr. Surg. pmid:25840069
Kim DS et al. Sphingosylphosphorylcholine inhibits melanin synthesis via pertussis toxin-sensitive MITF degradation. 2010 J. Pharm. Pharmacol. pmid:20487197
Mogi C et al. Sphingosylphosphorylcholine antagonizes proton-sensing ovarian cancer G-protein-coupled receptor 1 (OGR1)-mediated inositol phosphate production and cAMP accumulation. 2005 J. Pharmacol. Sci. pmid:16210776
Katayama T et al. Blebbistatin inhibits sphingosylphosphorylcholine-induced contraction of collagen-gel fiber populated by vascular smooth-muscle cells. 2006 J. Pharmacol. Sci. pmid:17072099
Seuwen K et al. Receptors for protons or lipid messengers or both? 2006 J. Recept. Signal Transduct. Res. pmid:17118800
Harris LJ et al. Differentiation of adult stem cells into smooth muscle for vascular tissue engineering. 2011 J. Surg. Res. pmid:19959190
Chen PF et al. Ca2+ signaling induced by sphingosylphosphorylcholine and sphingosine 1-phosphate via distinct mechanisms in rat glomerular mesangial cells. 1998 Kidney Int. pmid:9844123
Herzog C et al. Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury. 2010 Mediators Inflamm. pmid:21274265
Bae YC et al. Effects of sphingosylphosphorylcholine on cryopreserved fat tissue graft survival. 2016 Mol Med Rep pmid:27572900
Neri LM et al. Proliferating or differentiating stimuli act on different lipid-dependent signaling pathways in nuclei of human leukemia cells. 2002 Mol. Biol. Cell pmid:11907274
Jeong HS et al. PP2A and DUSP6 are involved in sphingosylphosphorylcholine-induced hypopigmentation. 2012 Mol. Cell. Biochem. pmid:22544520