sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

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Introduction

To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with sphingosylphosphorylcholine?

sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine

MeSH term MeSH ID Detail
Lupus Erythematosus, Systemic D008180 43 associated lipids
Insulinoma D007340 28 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Seizures D012640 87 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Endotoxemia D019446 27 associated lipids
Niemann-Pick Disease, Type A D052536 1 associated lipids
Niemann-Pick Disease, Type B D052537 1 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with sphingosylphosphorylcholine

Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with sphingosylphosphorylcholine?

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Location Cross reference Weighted score Related literatures
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What functions are associated with sphingosylphosphorylcholine?


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Function Cross reference Weighted score Related literatures

What lipids are associated with sphingosylphosphorylcholine?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with sphingosylphosphorylcholine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with sphingosylphosphorylcholine?

Mouse Model

Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with sphingosylphosphorylcholine

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Authors Title Published Journal PubMed Link
Afrasiabi E et al. Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. 2006 Cell. Signal. pmid:16490345
Czyborra C et al. Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16521006
Seuwen K et al. Receptors for protons or lipid messengers or both? 2006 J. Recept. Signal Transduct. Res. pmid:17118800
Alewijnse AE and Michel MC Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind? 2006 Br. J. Pharmacol. pmid:16402045
Mathieson FA and Nixon GF Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. 2006 Br. J. Pharmacol. pmid:16402047
Jeon ES et al. Sphingosylphosphorylcholine induces proliferation of human adipose tissue-derived mesenchymal stem cells via activation of JNK. 2006 J. Lipid Res. pmid:16339111
Kim DS et al. Sphingosylphosphorylcholine-induced ERK activation inhibits melanin synthesis in human melanocytes. 2006 Pigment Cell Res. pmid:16524430
Morikage N et al. Cholesterol primes vascular smooth muscle to induce Ca2 sensitization mediated by a sphingosylphosphorylcholine-Rho-kinase pathway: possible role for membrane raft. 2006 Circ. Res. pmid:16825579
Lee HY et al. Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis. 2006 Acta Pharmacol. Sin. pmid:17007744
Hemmings DG Signal transduction underlying the vascular effects of sphingosine 1-phosphate and sphingosylphosphorylcholine. 2006 Naunyn Schmiedebergs Arch. Pharmacol. pmid:16570136
Suresh S et al. Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. 2005 Acta Biomater pmid:16701777
Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4. 2005 J. Biol. Chem. pmid:16498716
Jeon ES et al. Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways. 2005 Cell. Signal. pmid:15722202
Jeon ES et al. Role of MEK-ERK pathway in sphingosylphosphorylcholine-induced cell death in human adipose tissue-derived mesenchymal stem cells. 2005 Biochim. Biophys. Acta pmid:15866480
Piao YJ et al. Involvement of urokinase-type plasminogen activator in sphingosylphosphorylcholine-induced angiogenesis. 2005 Exp. Dermatol. pmid:15854129
Lu X and Bittman R Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue. 2005 J. Org. Chem. pmid:15932314
Zhu MJ et al. Induction of connective tissue growth factor expression by sphingosylphosphorylcholine in cultured human skin fibroblasts. 2005 Exp. Dermatol. pmid:15946238
van Diggelen OP et al. A new fluorimetric enzyme assay for the diagnosis of Niemann-Pick A/B, with specificity of natural sphingomyelinase substrate. 2005 J. Inherit. Metab. Dis. pmid:16151905
Schubert R Non-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue. 2005 Cardiovasc. Res. pmid:16111665
Thomas GD et al. Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry. 2005 Cardiovasc. Res. pmid:15950201