sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.
To understand associated biological information of sphingosylphosphorylcholine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
sphingosylphosphorylcholine is suspected in Atherosclerosis, Niemann-Pick Diseases, Hypercholesterolemia, Dermatitis, Atopic, Chronic eczema, Cerebral Vasospasm and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with sphingosylphosphorylcholine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Endotoxemia | D019446 | 27 associated lipids |
| Niemann-Pick Disease, Type A | D052536 | 1 associated lipids |
| Niemann-Pick Disease, Type B | D052537 | 1 associated lipids |
Lipid pathways are not clear in current pathway databases. We organized associated pathways with sphingosylphosphorylcholine through full-text articles, including metabolic pathways or pathways of biological mechanisms.
| Pathway name | Related literatures |
|---|
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Sphingosylphosphorylcholine induces a hypertrophic growth response through the mitogen-activated protein kinase signaling cascade in rat neonatal cardiac myocytes.' (Sekiguchi K et al., 1999).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Imokawa G et al. | Sphingosylphosphorylcholine is a potent inducer of intercellular adhesion molecule-1 expression in human keratinocytes. | 1999 | J. Invest. Dermatol. | pmid:9886270 |
| Kye KC et al. | Signaling events during induction of plasminogen activator inhibitor-1 expression by sphingosylphosphorylcholine in cultured human dermal fibroblasts. | 2004 | J. Invest. Dermatol. | pmid:15175025 |
| Andoh T et al. | Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin. | 2009 | J. Invest. Dermatol. | pmid:19657356 |
| Sun L et al. | A new wound healing agent--sphingosylphosphorylcholine. | 1996 | J. Invest. Dermatol. | pmid:8601721 |
| Murata Y et al. | Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? | 1996 | J. Invest. Dermatol. | pmid:8752664 |
| Wakita H et al. | Sphingosylphosphorylcholine stimulates proliferation and upregulates cell surface-associated plasminogen activator activity in cultured human keratinocytes. | 1998 | J. Invest. Dermatol. | pmid:9506444 |
| van Diggelen OP et al. | A new fluorimetric enzyme assay for the diagnosis of Niemann-Pick A/B, with specificity of natural sphingomyelinase substrate. | 2005 | J. Inherit. Metab. Dis. | pmid:16151905 |
| Lee HY et al. | Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells. | 2011 | J. Immunol. | pmid:21368227 |
| Takenouchi T et al. | Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway. | 2008 | J. Immunol. | pmid:18523246 |
| Imokawa G | A possible mechanism underlying the ceramide deficiency in atopic dermatitis: expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide. | 2009 | J. Dermatol. Sci. | pmid:19443184 |