N,N-dimethylsphingosine

N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.

Cross Reference

Introduction

To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N,N-dimethylsphingosine?

N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Asthma D001249 52 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Proteinuria D011507 30 associated lipids
Trypanosomiasis, African D014353 5 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with N,N-dimethylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with N,N-dimethylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:

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What genes are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N,N-dimethylsphingosine?

Mouse Model

Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).

Knock-out

Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with N,N-dimethylsphingosine

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Authors Title Published Journal PubMed Link
Kono Y et al. Sphingosine kinase 1 regulates mucin production via ERK phosphorylation. 2010 Pulm Pharmacol Ther pmid:19835973
Habrukowich C et al. Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. 2010 J. Biol. Chem. pmid:20558741
Kolmakova A et al. VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo. 2009 Glycoconj. J. pmid:19219548
Ghosh SC et al. N,N-Dimethylsphingosine conjugates of poly-L-glutamic acid: synthesis, characterization, and initial biological evaluation. 2009 Bioorg. Med. Chem. Lett. pmid:19097786
Qu W et al. Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation. 2009 Bioorg. Med. Chem. Lett. pmid:19467599
Wong L et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. 2009 J. Med. Chem. pmid:19469544
Cattaneo MG et al. Oxytocin stimulates in vitro angiogenesis via a Pyk-2/Src-dependent mechanism. 2009 Exp. Cell Res. pmid:19563802
Sun D and Hurley LH The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression. 2009 J. Med. Chem. pmid:19385599
ter Braak M et al. Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. 2009 Biochim. Biophys. Acta pmid:19830907
Trifilieff A et al. Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. 2009 Naunyn Schmiedebergs Arch. Pharmacol. pmid:19636535