Qu W et al. |
Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation. |
2009 |
Bioorg. Med. Chem. Lett. |
pmid:19467599
|
De Jonghe S et al. |
Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase. |
1999 |
Bioorg. Med. Chem. Lett. |
pmid:10560747
|
Cuvillier O and Levade T |
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. |
2001 |
Blood |
pmid:11675357
|
Smith JJ et al. |
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. |
2009 |
BMC Syst Biol |
pmid:19284563
|
Qin X et al. |
Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels. |
2013 |
Br. J. Pharmacol. |
pmid:23145923
|
McDonald RA et al. |
The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia. |
2010 |
Br. J. Pharmacol. |
pmid:20015089
|
Camaré C et al. |
Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. |
2015 |
Br. J. Pharmacol. |
pmid:25176316
|
Shinpo K et al. |
Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. |
1999 |
Brain Res. |
pmid:10082875
|
Kleuser B et al. |
1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. |
1998 |
Cancer Res. |
pmid:9581819
|
Ohta H et al. |
Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. |
1995 |
Cancer Res. |
pmid:7834642
|
Okoshi H et al. |
Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. |
1991 |
Cancer Res. |
pmid:1657377
|
Nava VE et al. |
Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. |
2000 |
Cancer Res. |
pmid:10969794
|
Jin ZQ and Karliner JS |
Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism. |
2006 |
Cardiovasc. Res. |
pmid:16831409
|
Xiong TC et al. |
Sphingolipid metabolites selectively elicit increases in nuclear calcium concentration in cell suspension cultures and in isolated nuclei of tobacco. |
2008 |
Cell Calcium |
pmid:17570488
|
Woodcock JM et al. |
Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. |
2010 |
Cell. Signal. |
pmid:20403428
|
Billich A et al. |
Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. |
2005 |
Cell. Signal. |
pmid:16038795
|
Alfonso A et al. |
Prolactin induces calcium influx and release from intracellular pools in human T lymphocytes by activation of tyrosine kinases. |
2001 |
Cell. Signal. |
pmid:11583917
|
Sharma C et al. |
Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action. |
2000 |
Chem. Phys. Lipids |
pmid:10660207
|
Jin ZQ et al. |
Sphingosine kinase activation mediates ischemic preconditioning in murine heart. |
2004 |
Circulation |
pmid:15451787
|
Shirahama T et al. |
In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells. |
1997 |
Clin. Cancer Res. |
pmid:9815681
|