N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).
Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Xia P et al. | Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9826677 |
| Shirahama T et al. | In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells. | 1997 | Clin. Cancer Res. | pmid:9815681 |
| Banno Y et al. | Evidence for the presence of multiple forms of Sph kinase in human platelets. | 1998 | Biochem. J. | pmid:9761727 |
| Edsall LC et al. | N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. | 1998 | Biochemistry | pmid:9737868 |
| Megidish T et al. | A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein. | 1998 | J. Biol. Chem. | pmid:9705322 |
| Nakamura H et al. | Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells. | 1998 | J. Biol. Chem. | pmid:9624115 |
| Meyer zu Heringdorf D et al. | Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. | 1998 | EMBO J. | pmid:9582276 |
| Kleuser B et al. | 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. | 1998 | Cancer Res. | pmid:9581819 |
| Igarashi Y | [Bioregulatory functions of methylsphingosines: in relation to sphingolipid signaling pathway and on approach of introducing sphingolipid-based drugs]. | 1998 | Tanpakushitsu Kakusan Koso | pmid:9528354 |
| Caldwell C et al. | Regulatory differences among avian ecto-ATPases. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9325157 |
| Yatomi Y et al. | N,N-dimethylsphingosine phosphorylation in human platelets. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070908 |
| Sakakura C et al. | Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation. | 1996 | FEBS Lett. | pmid:8635587 |
| Sweeney EA et al. | Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. | 1996 | Int. J. Cancer | pmid:8621258 |
| Yatomi Y et al. | N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. | 1996 | Biochemistry | pmid:8555236 |
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| Lau B and Macdonald PM | Determination of the pKa of membrane-bound N,N-dimethylsphingosine using deuterium NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7619840 |
| Masamune A et al. | N,N,N-trimethylsphingosine inhibits interleukin-1 beta-induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells. | 1995 | FEBS Lett. | pmid:7540991 |
| Megidish T et al. | The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488188 |
| Fang J et al. | N,N-dimethylsphingosine attenuates myocardial ischemia-reperfusion injury by recruiting regulatory T cells through PI3K/Akt pathway in mice. | 2016 | Basic Res. Cardiol. | pmid:27048490 |
| Igarashi Y and Hakomori S | Enzymatic synthesis of N,N-dimethyl-sphingosine: demonstration of the sphingosine: N-methyltransferase in mouse brain. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2686639 |
| Zheng XD et al. | Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression. | 2014 Oct-Dec | Indian J Cancer | pmid:26842184 |
| Lei YC et al. | Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells. | 2015 | World J. Gastroenterol. | pmid:26676341 |
| Johnson CH et al. | Alterations in Spinal Cord Metabolism during Treatment of Neuropathic Pain. | 2015 | J Neuroimmune Pharmacol | pmid:26232265 |
| Zhang Z et al. | SPHK1 inhibitor suppresses cell proliferation and invasion associated with the inhibition of NF-κB pathway in hepatocellular carcinoma. | 2015 | Tumour Biol. | pmid:25537088 |
| Piccolini VM et al. | Cerebellum neurotransmission during postnatal development: [Pt(O,O'-acac)(γ-acac)(DMS)] vs cisplatin and neurotoxicity. | 2015 | Int. J. Dev. Neurosci. | pmid:25450526 |
| Asle-Rousta M et al. | Prominence of central sphingosine-1-phosphate receptor-1 in attenuating aβ-induced injury by fingolimod. | 2014 | J. Mol. Neurosci. | pmid:25239520 |
| Camaré C et al. | Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. | 2015 | Br. J. Pharmacol. | pmid:25176316 |
| Chen YJ et al. | Inflammation triggers production of dimethylsphingosine from oligodendrocytes. | 2014 | Neuroscience | pmid:25151189 |
| Chen K et al. | DMS triggers apoptosis associated with the inhibition of SPHK1/NF-κB activation and increase in intracellular Ca2+ concentration in human cancer cells. | 2014 | Int. J. Mol. Med. | pmid:24173614 |
| Leitzke AS et al. | Isoflurane post-treatment ameliorates GMH-induced brain injury in neonatal rats. | 2013 | Stroke | pmid:24149004 |
| Liu SQ et al. | [Sphingosine kinase 1 enhances the proliferation and invasion of human colon cancer LoVo cells through up-regulating FAK pathway and the expression of ICAM-1 and VCAM-1]. | 2013 | Zhonghua Zhong Liu Za Zhi | pmid:24054007 |
| Nam JH et al. | Sphingosine and FTY720 modulate pacemaking activity in interstitial cells of Cajal from mouse small intestine. | 2013 | Mol. Cells | pmid:23912597 |
| Igarashi Y et al. | A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. | 1990 | J. Biol. Chem. | pmid:2318819 |
| Qin X et al. | Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels. | 2013 | Br. J. Pharmacol. | pmid:23145923 |
| Yin GJ et al. | [Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro]. | 2012 | Zhonghua Zhong Liu Za Zhi | pmid:22780925 |
| Liu SQ et al. | Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways. | 2012 | Int J Colorectal Dis | pmid:22684547 |
| Chan L | Harnessing regulatory T cells for therapeutic purposes. | 2012 | Kidney Int. | pmid:22543901 |
| Khan WA et al. | Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2241961 |
| Lai LW et al. | Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury. | 2012 | Kidney Int. | pmid:22189844 |
| Hasan NM et al. | Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line. | 2012 | Arch. Biochem. Biophys. | pmid:22155656 |
| Felding-Habermann B et al. | A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis. | 1990 | Biochemistry | pmid:2207076 |
| Lan T et al. | Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells. | 2011 | Mol. Endocrinol. | pmid:21998146 |
| Yoshimitsu Y et al. | Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C. | 2011 | Bioorg. Med. Chem. | pmid:21868240 |
| Kanno T and Nishizaki T | Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors. | 2011 | Life Sci. | pmid:21683714 |
| Alden KP et al. | Sphingolipid long chain base phosphates can regulate apoptotic-like programmed cell death in plants. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21683064 |
| Liu SQ et al. | [Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer HT-29 cells and its molecular mechanisms]. | 2011 | Zhonghua Zhong Liu Za Zhi | pmid:21575515 |
| Yu HM et al. | [Regulation of sphingosine kinase 1 in the TNF-α-induced expression of MUC5AC in airway epithelial cells]. | 2011 | Zhonghua Yi Xue Za Zhi | pmid:21418911 |
| Li QF et al. | Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21195056 |
| Habrukowich C et al. | Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. | 2010 | J. Biol. Chem. | pmid:20558741 |
| Woodcock JM et al. | Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. | 2010 | Cell. Signal. | pmid:20403428 |
| Lan T et al. | Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry. | 2010 | Biomed. Chromatogr. | pmid:20352614 |
| McDonald RA et al. | The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia. | 2010 | Br. J. Pharmacol. | pmid:20015089 |
| Itagaki K et al. | Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils. | 2010 | Shock | pmid:19851125 |
| Kono Y et al. | Sphingosine kinase 1 regulates mucin production via ERK phosphorylation. | 2010 | Pulm Pharmacol Ther | pmid:19835973 |
| ter Braak M et al. | Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. | 2009 | Biochim. Biophys. Acta | pmid:19830907 |
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| Cattaneo MG et al. | Oxytocin stimulates in vitro angiogenesis via a Pyk-2/Src-dependent mechanism. | 2009 | Exp. Cell Res. | pmid:19563802 |
| Wong L et al. | Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. | 2009 | J. Med. Chem. | pmid:19469544 |
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| Kolmakova A et al. | VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo. | 2009 | Glycoconj. J. | pmid:19219548 |
| Ghosh SC et al. | N,N-Dimethylsphingosine conjugates of poly-L-glutamic acid: synthesis, characterization, and initial biological evaluation. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19097786 |
| Lai WQ et al. | Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis. | 2008 | J. Immunol. | pmid:19017993 |
| Wang H et al. | N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. | 2008 | Mol. Cancer Ther. | pmid:18790777 |
| Jo JY et al. | N,N-Dimethyl-D-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes. | 2008 | J. Pharmacol. Sci. | pmid:18635921 |
| Jin YX et al. | A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry. | 2008 | Anal. Biochem. | pmid:18541132 |
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| Kim HL et al. | Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18467142 |
| Zhang YH et al. | Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway. | 2008 | J. Physiol. (Lond.) | pmid:18450779 |
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| Kim HL and Im DS | N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells. | 2008 | Arch. Pharm. Res. | pmid:18277608 |
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| Vessey DA et al. | Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17912702 |
| Leroux ME et al. | Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. | 2007 | Prostate | pmid:17879964 |
| Xiong TC et al. | Sphingolipid metabolites selectively elicit increases in nuclear calcium concentration in cell suspension cultures and in isolated nuclei of tobacco. | 2008 | Cell Calcium | pmid:17570488 |
| Coatrieux C et al. | MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. | 2007 | Free Radic. Biol. Med. | pmid:17561096 |
| Kim HJ et al. | Suppression of osteoclastogenesis by N,N-dimethyl-D-erythro-sphingosine: a sphingosine kinase inhibition-independent action. | 2007 | Mol. Pharmacol. | pmid:17504945 |
| Lee YK et al. | Multiple actions of dimethylsphingosine in 1321N1 astrocytes. | 2007 | Mol. Cells | pmid:17464206 |
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| Chandru H and Boggaram V | The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells. | 2007 | Gene | pmid:17306937 |
| Jin YX et al. | Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography. | 2006 | Arch. Pharm. Res. | pmid:17146975 |
| Maines LW et al. | Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17065523 |
| Chang YJ et al. | Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line. | 2006 | Arch. Pharm. Res. | pmid:16964761 |
| Lee YK et al. | Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16904073 |
| Jin ZQ and Karliner JS | Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism. | 2006 | Cardiovasc. Res. | pmid:16831409 |
| Zhang YH et al. | Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons. | 2006 | J. Physiol. (Lond.) | pmid:16740613 |
| Lee EH et al. | Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes. | 2006 | J. Pharmacol. Sci. | pmid:16575153 |
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| Billich A et al. | Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. | 2005 | Cell. Signal. | pmid:16038795 |
| Ohmori T et al. | The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets. | 2005 | Thromb. Res. | pmid:15733975 |
| Min J et al. | Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin. | 2005 | Eukaryotic Cell | pmid:15643073 |
| Park HW et al. | Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells. | 2004 | Exp. Mol. Med. | pmid:15557813 |
| Jin ZQ et al. | Sphingosine kinase activation mediates ischemic preconditioning in murine heart. | 2004 | Circulation | pmid:15451787 |