N,N-dimethylsphingosine

N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.

Cross Reference

Introduction

To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N,N-dimethylsphingosine?

N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Asthma D001249 52 associated lipids
Proteinuria D011507 30 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Trypanosomiasis, African D014353 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with N,N-dimethylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with N,N-dimethylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N,N-dimethylsphingosine?

Mouse Model

Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).

Knock-out

Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with N,N-dimethylsphingosine

Download all related citations
Per page 10 20 50 100 | Total 149
Authors Title Published Journal PubMed Link
pmid:
Nishiuma T et al. Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model. 2008 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:18359884
Zanin M et al. Trophic action of sphingosine 1-phosphate in denervated rat soleus muscle. 2008 Am. J. Physiol., Cell Physiol. pmid:17942639
Souktani R et al. Induction of apoptosis using sphingolipids activates a chloride current in Xenopus laevis oocytes. 2000 Am. J. Physiol., Cell Physiol. pmid:10898727
Sykes ML and Avery VM Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427. 2009 Am. J. Trop. Med. Hyg. pmid:19815884
Jin YX et al. A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry. 2008 Anal. Biochem. pmid:18541132
Cavallini L et al. Ganglioside GM1 protection from apoptosis of rat heart fibroblasts. 1999 Arch. Biochem. Biophys. pmid:10510273
Hasan NM et al. Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line. 2012 Arch. Biochem. Biophys. pmid:22155656
Chang YJ et al. Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line. 2006 Arch. Pharm. Res. pmid:16964761
Kim HL and Im DS N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells. 2008 Arch. Pharm. Res. pmid:18277608