N,N-dimethylsphingosine

N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.

Cross Reference

Introduction

To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N,N-dimethylsphingosine?

N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Asthma D001249 52 associated lipids
Proteinuria D011507 30 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Trypanosomiasis, African D014353 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with N,N-dimethylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with N,N-dimethylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N,N-dimethylsphingosine?

Mouse Model

Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).

Knock-out

Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with N,N-dimethylsphingosine

Download all related citations
Per page 10 20 50 100 | Total 149
Authors Title Published Journal PubMed Link
pmid:
Igarashi Y and Hakomori S Enzymatic synthesis of N,N-dimethyl-sphingosine: demonstration of the sphingosine: N-methyltransferase in mouse brain. 1989 Biochem. Biophys. Res. Commun. pmid:2686639
Felding-Habermann B et al. A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis. 1990 Biochemistry pmid:2207076
Igarashi Y et al. A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. 1990 J. Biol. Chem. pmid:2318819
Khan WA et al. Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. 1990 Biochem. Biophys. Res. Commun. pmid:2241961
Okoshi H et al. Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. 1991 Cancer Res. pmid:1657377
Uemura K et al. Inhibition of neurite outgrowth in neuroblastoma cells by sphingosine. 1993 J. Biochem. pmid:8276777
Lau B and Macdonald PM Determination of the pKa of membrane-bound N,N-dimethylsphingosine using deuterium NMR spectroscopy. 1995 Biochim. Biophys. Acta pmid:7619840
Masamune A et al. N,N,N-trimethylsphingosine inhibits interleukin-1 beta-induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells. 1995 FEBS Lett. pmid:7540991
Megidish T et al. The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells. 1995 Biochem. Biophys. Res. Commun. pmid:7488188