N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).
Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fang J et al. | N,N-dimethylsphingosine attenuates myocardial ischemia-reperfusion injury by recruiting regulatory T cells through PI3K/Akt pathway in mice. | 2016 | Basic Res. Cardiol. | pmid:27048490 |
| Johnson CH et al. | Alterations in Spinal Cord Metabolism during Treatment of Neuropathic Pain. | 2015 | J Neuroimmune Pharmacol | pmid:26232265 |
| Zhang Z et al. | SPHK1 inhibitor suppresses cell proliferation and invasion associated with the inhibition of NF-κB pathway in hepatocellular carcinoma. | 2015 | Tumour Biol. | pmid:25537088 |
| Piccolini VM et al. | Cerebellum neurotransmission during postnatal development: [Pt(O,O'-acac)(γ-acac)(DMS)] vs cisplatin and neurotoxicity. | 2015 | Int. J. Dev. Neurosci. | pmid:25450526 |
| Lei YC et al. | Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells. | 2015 | World J. Gastroenterol. | pmid:26676341 |
| Camaré C et al. | Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. | 2015 | Br. J. Pharmacol. | pmid:25176316 |
| Zheng XD et al. | Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression. | 2014 Oct-Dec | Indian J Cancer | pmid:26842184 |
| Chen K et al. | DMS triggers apoptosis associated with the inhibition of SPHK1/NF-κB activation and increase in intracellular Ca2+ concentration in human cancer cells. | 2014 | Int. J. Mol. Med. | pmid:24173614 |
| Asle-Rousta M et al. | Prominence of central sphingosine-1-phosphate receptor-1 in attenuating aβ-induced injury by fingolimod. | 2014 | J. Mol. Neurosci. | pmid:25239520 |
| Chen YJ et al. | Inflammation triggers production of dimethylsphingosine from oligodendrocytes. | 2014 | Neuroscience | pmid:25151189 |
| Qin X et al. | Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels. | 2013 | Br. J. Pharmacol. | pmid:23145923 |
| Liu SQ et al. | [Sphingosine kinase 1 enhances the proliferation and invasion of human colon cancer LoVo cells through up-regulating FAK pathway and the expression of ICAM-1 and VCAM-1]. | 2013 | Zhonghua Zhong Liu Za Zhi | pmid:24054007 |
| Leitzke AS et al. | Isoflurane post-treatment ameliorates GMH-induced brain injury in neonatal rats. | 2013 | Stroke | pmid:24149004 |
| Nam JH et al. | Sphingosine and FTY720 modulate pacemaking activity in interstitial cells of Cajal from mouse small intestine. | 2013 | Mol. Cells | pmid:23912597 |
| Chan L | Harnessing regulatory T cells for therapeutic purposes. | 2012 | Kidney Int. | pmid:22543901 |
| Hasan NM et al. | Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line. | 2012 | Arch. Biochem. Biophys. | pmid:22155656 |
| Lai LW et al. | Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury. | 2012 | Kidney Int. | pmid:22189844 |
| Yin GJ et al. | [Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro]. | 2012 | Zhonghua Zhong Liu Za Zhi | pmid:22780925 |
| Liu SQ et al. | Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways. | 2012 | Int J Colorectal Dis | pmid:22684547 |
| Yoshimitsu Y et al. | Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C. | 2011 | Bioorg. Med. Chem. | pmid:21868240 |
| Alden KP et al. | Sphingolipid long chain base phosphates can regulate apoptotic-like programmed cell death in plants. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21683064 |
| Kanno T and Nishizaki T | Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors. | 2011 | Life Sci. | pmid:21683714 |
| Li QF et al. | Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21195056 |
| Lan T et al. | Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells. | 2011 | Mol. Endocrinol. | pmid:21998146 |
| Yu HM et al. | [Regulation of sphingosine kinase 1 in the TNF-α-induced expression of MUC5AC in airway epithelial cells]. | 2011 | Zhonghua Yi Xue Za Zhi | pmid:21418911 |
| Liu SQ et al. | [Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer HT-29 cells and its molecular mechanisms]. | 2011 | Zhonghua Zhong Liu Za Zhi | pmid:21575515 |
| Woodcock JM et al. | Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. | 2010 | Cell. Signal. | pmid:20403428 |
| Kono Y et al. | Sphingosine kinase 1 regulates mucin production via ERK phosphorylation. | 2010 | Pulm Pharmacol Ther | pmid:19835973 |
| Habrukowich C et al. | Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. | 2010 | J. Biol. Chem. | pmid:20558741 |
| Itagaki K et al. | Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils. | 2010 | Shock | pmid:19851125 |
| Lan T et al. | Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry. | 2010 | Biomed. Chromatogr. | pmid:20352614 |
| McDonald RA et al. | The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia. | 2010 | Br. J. Pharmacol. | pmid:20015089 |
| Kolmakova A et al. | VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo. | 2009 | Glycoconj. J. | pmid:19219548 |
| Ghosh SC et al. | N,N-Dimethylsphingosine conjugates of poly-L-glutamic acid: synthesis, characterization, and initial biological evaluation. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19097786 |
| Qu W et al. | Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19467599 |
| Wong L et al. | Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. | 2009 | J. Med. Chem. | pmid:19469544 |
| Cattaneo MG et al. | Oxytocin stimulates in vitro angiogenesis via a Pyk-2/Src-dependent mechanism. | 2009 | Exp. Cell Res. | pmid:19563802 |
| Sun D and Hurley LH | The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression. | 2009 | J. Med. Chem. | pmid:19385599 |
| ter Braak M et al. | Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. | 2009 | Biochim. Biophys. Acta | pmid:19830907 |
| Sykes ML and Avery VM | Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427. | 2009 | Am. J. Trop. Med. Hyg. | pmid:19815884 |
| Smith JJ et al. | Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. | 2009 | BMC Syst Biol | pmid:19284563 |
| Trifilieff A et al. | Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19636535 |
| Wang H et al. | N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. | 2008 | Mol. Cancer Ther. | pmid:18790777 |
| Xiong TC et al. | Sphingolipid metabolites selectively elicit increases in nuclear calcium concentration in cell suspension cultures and in isolated nuclei of tobacco. | 2008 | Cell Calcium | pmid:17570488 |
| Lai WQ et al. | The role of sphingosine kinase in a murine model of allergic asthma. | 2008 | J. Immunol. | pmid:18322246 |
| Kim HL et al. | Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18316219 |
| Jin YX et al. | A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry. | 2008 | Anal. Biochem. | pmid:18541132 |
| Zhang YH et al. | Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway. | 2008 | J. Physiol. (Lond.) | pmid:18450779 |
| Kim HL et al. | Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18467142 |
| Jo JY et al. | N,N-Dimethyl-D-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes. | 2008 | J. Pharmacol. Sci. | pmid:18635921 |
| Nagaoka Y et al. | Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. | 2008 | Biol. Pharm. Bull. | pmid:18520051 |
| Nishiuma T et al. | Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18359884 |
| Lai WQ et al. | Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis. | 2008 | J. Immunol. | pmid:19017993 |
| Zanin M et al. | Trophic action of sphingosine 1-phosphate in denervated rat soleus muscle. | 2008 | Am. J. Physiol., Cell Physiol. | pmid:17942639 |
| Kim HL and Im DS | N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells. | 2008 | Arch. Pharm. Res. | pmid:18277608 |
| Gude DR et al. | Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. | 2008 | FASEB J. | pmid:18362204 |
| Ghosh SC et al. | N,N-dimethylsphingosine-coumarin: synthesis, chemical characterization, and biological evaluation. | 2007 May-Jun | Bioconjug. Chem. | pmid:17432826 |
| Vessey DA et al. | Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17912702 |
| Kim HJ et al. | Suppression of osteoclastogenesis by N,N-dimethyl-D-erythro-sphingosine: a sphingosine kinase inhibition-independent action. | 2007 | Mol. Pharmacol. | pmid:17504945 |
| Lee YK et al. | Multiple actions of dimethylsphingosine in 1321N1 astrocytes. | 2007 | Mol. Cells | pmid:17464206 |
| Leroux ME et al. | Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. | 2007 | Prostate | pmid:17879964 |
| Chandru H and Boggaram V | The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells. | 2007 | Gene | pmid:17306937 |
| Coatrieux C et al. | MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. | 2007 | Free Radic. Biol. Med. | pmid:17561096 |
| Jin YX et al. | Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography. | 2006 | Arch. Pharm. Res. | pmid:17146975 |
| Chang YJ et al. | Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line. | 2006 | Arch. Pharm. Res. | pmid:16964761 |
| Jin ZQ and Karliner JS | Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism. | 2006 | Cardiovasc. Res. | pmid:16831409 |
| Zhang YH et al. | Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons. | 2006 | J. Physiol. (Lond.) | pmid:16740613 |
| Lee YK et al. | Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16904073 |
| Lee EH et al. | Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes. | 2006 | J. Pharmacol. Sci. | pmid:16575153 |
| Maines LW et al. | Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17065523 |
| Min J et al. | Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin. | 2005 | Eukaryotic Cell | pmid:15643073 |
| Billich A et al. | Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. | 2005 | Cell. Signal. | pmid:16038795 |
| Saini HS et al. | Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. | 2005 | J. Neurochem. | pmid:16313513 |
| Ohmori T et al. | The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets. | 2005 | Thromb. Res. | pmid:15733975 |
| Meacci E et al. | Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts. | 2004 | Biochem. J. | pmid:15109308 |
| Park HW et al. | Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells. | 2004 | Exp. Mol. Med. | pmid:15557813 |
| Jin ZQ et al. | Sphingosine kinase activation mediates ischemic preconditioning in murine heart. | 2004 | Circulation | pmid:15451787 |
| Worgall TS et al. | Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15132973 |
| Welsch CA et al. | Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine. | 2004 | J. Biol. Chem. | pmid:15190065 |
| Kaneider NC et al. | The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. | 2004 | FASEB J. | pmid:15208267 |
| Van IJzendoorn SC et al. | Polarized membrane traffic and cell polarity development is dependent on dihydroceramide synthase-regulated sphinganine turnover. | 2004 | Mol. Biol. Cell | pmid:15229289 |
| Roth Z and Hansen PJ | Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. | 2004 | Biol. Reprod. | pmid:15317688 |
| Min J et al. | Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs. | 2004 | Eukaryotic Cell | pmid:15190000 |
| Ibrahim FB et al. | Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase. | 2004 | J. Biol. Chem. | pmid:15302883 |
| Kaneider NC et al. | Heparan sulfate proteoglycans are involved in opiate receptor-mediated cell migration. | 2004 | Biochemistry | pmid:14705951 |
| Duan HF et al. | Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. | 2004 | Exp. Cell Res. | pmid:15265705 |
| Alfonso A et al. | Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes. | 2003 | Biochem. Pharmacol. | pmid:12527340 |
| Seko A et al. | Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X. | 2003 | J. Biol. Chem. | pmid:12511560 |
| Kaneider NC et al. | Leukocyte motility in response to neuropeptides is heparan sulfate proteoglycan dependent. | 2003 | Peptides | pmid:12895655 |
| MacKinnon AC et al. | Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. | 2002 | J. Immunol. | pmid:12444147 |
| Hanafusa N et al. | Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. | 2002 | Nephrol. Dial. Transplant. | pmid:11917049 |
| McCaig C et al. | Signalling pathways involved in the direct effects of IGFBP-5 on breast epithelial cell attachment and survival. | 2002 | J. Cell. Biochem. | pmid:11835403 |
| Pallis M | Sphingosine kinase inhibitors in the apoptosis of leukaemia cells. | 2002 | Leuk. Res. | pmid:11839389 |
| Jendiroba DB et al. | Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine. | 2002 | Leuk. Res. | pmid:11792420 |
| Ren J et al. | Expression of sphingosine kinase gene in the interactions between human gastric carcinoma cell and vascular endothelial cell. | 2002 | World J. Gastroenterol. | pmid:12174364 |
| Xu CB et al. | D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. | 2002 | Atherosclerosis | pmid:12204793 |
| Osawa Y et al. | TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. | 2001 | J. Immunol. | pmid:11418646 |
| Cuvillier O and Levade T | Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. | 2001 | Blood | pmid:11675357 |
| Manggau M et al. | 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. | 2001 | J. Invest. Dermatol. | pmid:11710939 |
| Alemany R et al. | Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. | 2001 | FEBS Lett. | pmid:11741596 |