|
|
|
|
pmid:
|
Nishiuma T et al. |
Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model. |
2008 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:18359884
|
Zanin M et al. |
Trophic action of sphingosine 1-phosphate in denervated rat soleus muscle. |
2008 |
Am. J. Physiol., Cell Physiol. |
pmid:17942639
|
Souktani R et al. |
Induction of apoptosis using sphingolipids activates a chloride current in Xenopus laevis oocytes. |
2000 |
Am. J. Physiol., Cell Physiol. |
pmid:10898727
|
Sykes ML and Avery VM |
Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427. |
2009 |
Am. J. Trop. Med. Hyg. |
pmid:19815884
|
Jin YX et al. |
A sphingosine kinase activity assay using direct infusion electrospray ionization tandem mass spectrometry. |
2008 |
Anal. Biochem. |
pmid:18541132
|
Cavallini L et al. |
Ganglioside GM1 protection from apoptosis of rat heart fibroblasts. |
1999 |
Arch. Biochem. Biophys. |
pmid:10510273
|
Hasan NM et al. |
Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line. |
2012 |
Arch. Biochem. Biophys. |
pmid:22155656
|
Jin YX et al. |
Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography. |
2006 |
Arch. Pharm. Res. |
pmid:17146975
|
Chang YJ et al. |
Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line. |
2006 |
Arch. Pharm. Res. |
pmid:16964761
|
Kim HL and Im DS |
N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells. |
2008 |
Arch. Pharm. Res. |
pmid:18277608
|
Worgall TS et al. |
Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein. |
2004 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:15132973
|
Xu CB et al. |
D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. |
2002 |
Atherosclerosis |
pmid:12204793
|
Fang J et al. |
N,N-dimethylsphingosine attenuates myocardial ischemia-reperfusion injury by recruiting regulatory T cells through PI3K/Akt pathway in mice. |
2016 |
Basic Res. Cardiol. |
pmid:27048490
|
Alden KP et al. |
Sphingolipid long chain base phosphates can regulate apoptotic-like programmed cell death in plants. |
2011 |
Biochem. Biophys. Res. Commun. |
pmid:21683064
|
Lee YK et al. |
Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes. |
2006 |
Biochem. Biophys. Res. Commun. |
pmid:16904073
|
Osawa Y et al. |
Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor. |
2001 |
Biochem. Biophys. Res. Commun. |
pmid:11520048
|
Igarashi Y and Hakomori S |
Enzymatic synthesis of N,N-dimethyl-sphingosine: demonstration of the sphingosine: N-methyltransferase in mouse brain. |
1989 |
Biochem. Biophys. Res. Commun. |
pmid:2686639
|
Khan WA et al. |
Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. |
1990 |
Biochem. Biophys. Res. Commun. |
pmid:2241961
|
Megidish T et al. |
The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells. |
1995 |
Biochem. Biophys. Res. Commun. |
pmid:7488188
|
Caldwell C et al. |
Regulatory differences among avian ecto-ATPases. |
1997 |
Biochem. Biophys. Res. Commun. |
pmid:9325157
|
Yatomi Y et al. |
N,N-dimethylsphingosine phosphorylation in human platelets. |
1997 |
Biochem. Biophys. Res. Commun. |
pmid:9070908
|
Li QF et al. |
Bortezomib and sphingosine kinase inhibitor interact synergistically to induces apoptosis in BCR/ABl+ cells sensitive and resistant to STI571 through down-regulation Mcl-1. |
2011 |
Biochem. Biophys. Res. Commun. |
pmid:21195056
|
Meacci E et al. |
Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts. |
2004 |
Biochem. J. |
pmid:15109308
|
Banno Y et al. |
Evidence for the presence of multiple forms of Sph kinase in human platelets. |
1998 |
Biochem. J. |
pmid:9761727
|
Young KW et al. |
Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation. |
1999 |
Biochem. J. |
pmid:10493910
|
Kim YK et al. |
Differential regulation of protein tyrosine kinase on free radical production, granule enzyme release, and cytokine synthesis by activated murine peritoneal macrophages. |
2001 |
Biochem. Pharmacol. |
pmid:11137713
|
Alfonso A et al. |
Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes. |
2003 |
Biochem. Pharmacol. |
pmid:12527340
|
Edsall LC et al. |
N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. |
1998 |
Biochemistry |
pmid:9737868
|
Yatomi Y et al. |
N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. |
1996 |
Biochemistry |
pmid:8555236
|
Felding-Habermann B et al. |
A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis. |
1990 |
Biochemistry |
pmid:2207076
|
Kaneider NC et al. |
Heparan sulfate proteoglycans are involved in opiate receptor-mediated cell migration. |
2004 |
Biochemistry |
pmid:14705951
|
ter Braak M et al. |
Galpha(q)-mediated plasma membrane translocation of sphingosine kinase-1 and cross-activation of S1P receptors. |
2009 |
Biochim. Biophys. Acta |
pmid:19830907
|
Lau B and Macdonald PM |
Determination of the pKa of membrane-bound N,N-dimethylsphingosine using deuterium NMR spectroscopy. |
1995 |
Biochim. Biophys. Acta |
pmid:7619840
|
Ghosh SC et al. |
N,N-dimethylsphingosine-coumarin: synthesis, chemical characterization, and biological evaluation. |
2007 May-Jun |
Bioconjug. Chem. |
pmid:17432826
|
Nagaoka Y et al. |
Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. |
2008 |
Biol. Pharm. Bull. |
pmid:18520051
|
Roth Z and Hansen PJ |
Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. |
2004 |
Biol. Reprod. |
pmid:15317688
|
Lan T et al. |
Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry. |
2010 |
Biomed. Chromatogr. |
pmid:20352614
|
Yoshimitsu Y et al. |
Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C. |
2011 |
Bioorg. Med. Chem. |
pmid:21868240
|
Ghosh SC et al. |
N,N-Dimethylsphingosine conjugates of poly-L-glutamic acid: synthesis, characterization, and initial biological evaluation. |
2009 |
Bioorg. Med. Chem. Lett. |
pmid:19097786
|
Qu W et al. |
Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation. |
2009 |
Bioorg. Med. Chem. Lett. |
pmid:19467599
|
De Jonghe S et al. |
Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase. |
1999 |
Bioorg. Med. Chem. Lett. |
pmid:10560747
|
Cuvillier O and Levade T |
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. |
2001 |
Blood |
pmid:11675357
|
Smith JJ et al. |
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. |
2009 |
BMC Syst Biol |
pmid:19284563
|
Qin X et al. |
Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels. |
2013 |
Br. J. Pharmacol. |
pmid:23145923
|
McDonald RA et al. |
The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia. |
2010 |
Br. J. Pharmacol. |
pmid:20015089
|
Camaré C et al. |
Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. |
2015 |
Br. J. Pharmacol. |
pmid:25176316
|
Shinpo K et al. |
Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. |
1999 |
Brain Res. |
pmid:10082875
|
Okoshi H et al. |
Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. |
1991 |
Cancer Res. |
pmid:1657377
|
Nava VE et al. |
Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. |
2000 |
Cancer Res. |
pmid:10969794
|