N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).
Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Osawa Y et al. | TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. | 2001 | J. Immunol. | pmid:11418646 |
| Karliner JS et al. | The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. | 2001 | J. Mol. Cell. Cardiol. | pmid:11549349 |
| Cuvillier O and Levade T | Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. | 2001 | Blood | pmid:11675357 |
| Manggau M et al. | 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. | 2001 | J. Invest. Dermatol. | pmid:11710939 |
| Hobson JP et al. | Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. | 2001 | Science | pmid:11230698 |
| Osawa Y et al. | Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11520048 |
| Kim YK et al. | Differential regulation of protein tyrosine kinase on free radical production, granule enzyme release, and cytokine synthesis by activated murine peritoneal macrophages. | 2001 | Biochem. Pharmacol. | pmid:11137713 |
| Sharma C et al. | Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action. | 2000 | Chem. Phys. Lipids | pmid:10660207 |
| Young KW et al. | Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells. | 2000 | Eur. J. Pharmacol. | pmid:10940357 |
| Young KW et al. | Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. | 2000 | J. Biol. Chem. | pmid:10954727 |
| Okamoto H et al. | Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration. | 2000 | Thromb. Res. | pmid:10942792 |
| Walev I et al. | Streptolysin O-permeabilized granulocytes shed L-selectin concomitantly with ceramide generation via neutral sphingomyelinase. | 2000 | J. Leukoc. Biol. | pmid:11129654 |
| Chuang FY et al. | Convergence of Fc gamma receptor IIA and Fc gamma receptor IIIB signaling pathways in human neutrophils. | 2000 | J. Immunol. | pmid:10605030 |
| Cuvillier O et al. | Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. | 2000 | J. Biol. Chem. | pmid:10747891 |
| Liu H et al. | Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. | 2000 | J. Biol. Chem. | pmid:10751414 |
| Nava VE et al. | Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. | 2000 | Cancer Res. | pmid:10969794 |
| Souktani R et al. | Induction of apoptosis using sphingolipids activates a chloride current in Xenopus laevis oocytes. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10898727 |
| Shinpo K et al. | Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. | 1999 | Brain Res. | pmid:10082875 |
| Olivera A et al. | Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. | 1999 | J. Cell Biol. | pmid:10545499 |
| Cavallini L et al. | Ganglioside GM1 protection from apoptosis of rat heart fibroblasts. | 1999 | Arch. Biochem. Biophys. | pmid:10510273 |
| De Jonghe S et al. | Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10560747 |
| Xia P et al. | Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. | 1999 | J. Biol. Chem. | pmid:10567432 |
| Young KW et al. | Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation. | 1999 | Biochem. J. | pmid:10493910 |
| Yang L et al. | Sphingosine 1-phosphate formation and intracellular Ca2+ mobilization in human platelets: evaluation with sphingosine kinase inhibitors. | 1999 | J. Biochem. | pmid:10393324 |
| Kleuser B et al. | 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. | 1998 | Cancer Res. | pmid:9581819 |
| Edsall LC et al. | N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. | 1998 | Biochemistry | pmid:9737868 |
| Nakamura H et al. | Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells. | 1998 | J. Biol. Chem. | pmid:9624115 |
| Banno Y et al. | Evidence for the presence of multiple forms of Sph kinase in human platelets. | 1998 | Biochem. J. | pmid:9761727 |
| Xia P et al. | Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9826677 |
| Meyer zu Heringdorf D et al. | Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. | 1998 | EMBO J. | pmid:9582276 |
| Igarashi Y | [Bioregulatory functions of methylsphingosines: in relation to sphingolipid signaling pathway and on approach of introducing sphingolipid-based drugs]. | 1998 | Tanpakushitsu Kakusan Koso | pmid:9528354 |
| Megidish T et al. | A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein. | 1998 | J. Biol. Chem. | pmid:9705322 |
| Shirahama T et al. | In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells. | 1997 | Clin. Cancer Res. | pmid:9815681 |
| Caldwell C et al. | Regulatory differences among avian ecto-ATPases. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9325157 |
| Yatomi Y et al. | N,N-dimethylsphingosine phosphorylation in human platelets. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9070908 |
| Sakakura C et al. | Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation. | 1996 | FEBS Lett. | pmid:8635587 |
| Yatomi Y et al. | N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. | 1996 | Biochemistry | pmid:8555236 |
| Sweeney EA et al. | Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. | 1996 | Int. J. Cancer | pmid:8621258 |
| Ohta H et al. | Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. | 1995 | Cancer Res. | pmid:7834642 |
| Lau B and Macdonald PM | Determination of the pKa of membrane-bound N,N-dimethylsphingosine using deuterium NMR spectroscopy. | 1995 | Biochim. Biophys. Acta | pmid:7619840 |
| Masamune A et al. | N,N,N-trimethylsphingosine inhibits interleukin-1 beta-induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells. | 1995 | FEBS Lett. | pmid:7540991 |
| Megidish T et al. | The signal modulator protein 14-3-3 is a target of sphingosine- or N,N-dimethylsphingosine-dependent kinase in 3T3(A31) cells. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488188 |
| Uemura K et al. | Inhibition of neurite outgrowth in neuroblastoma cells by sphingosine. | 1993 | J. Biochem. | pmid:8276777 |
| Okoshi H et al. | Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. | 1991 | Cancer Res. | pmid:1657377 |
| Felding-Habermann B et al. | A ceramide analogue inhibits T cell proliferative response through inhibition of glycosphingolipid synthesis and enhancement of N,N-dimethylsphingosine synthesis. | 1990 | Biochemistry | pmid:2207076 |
| Igarashi Y et al. | A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. | 1990 | J. Biol. Chem. | pmid:2318819 |
| Khan WA et al. | Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2241961 |
| Igarashi Y and Hakomori S | Enzymatic synthesis of N,N-dimethyl-sphingosine: demonstration of the sphingosine: N-methyltransferase in mouse brain. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2686639 |
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