N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).
Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kleuser B et al. | 1Alpha,25-dihydroxyvitamin D3 inhibits programmed cell death in HL-60 cells by activation of sphingosine kinase. | 1998 | Cancer Res. | pmid:9581819 |
| Ohta H et al. | Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. | 1995 | Cancer Res. | pmid:7834642 |
| Jin ZQ and Karliner JS | Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism. | 2006 | Cardiovasc. Res. | pmid:16831409 |
| Xiong TC et al. | Sphingolipid metabolites selectively elicit increases in nuclear calcium concentration in cell suspension cultures and in isolated nuclei of tobacco. | 2008 | Cell Calcium | pmid:17570488 |
| Woodcock JM et al. | Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function. | 2010 | Cell. Signal. | pmid:20403428 |
| Billich A et al. | Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. | 2005 | Cell. Signal. | pmid:16038795 |
| Alfonso A et al. | Prolactin induces calcium influx and release from intracellular pools in human T lymphocytes by activation of tyrosine kinases. | 2001 | Cell. Signal. | pmid:11583917 |
| Sharma C et al. | Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action. | 2000 | Chem. Phys. Lipids | pmid:10660207 |
| Jin ZQ et al. | Sphingosine kinase activation mediates ischemic preconditioning in murine heart. | 2004 | Circulation | pmid:15451787 |
| Shirahama T et al. | In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells. | 1997 | Clin. Cancer Res. | pmid:9815681 |
| Meyer zu Heringdorf D et al. | Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. | 1998 | EMBO J. | pmid:9582276 |
| Min J et al. | Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin. | 2005 | Eukaryotic Cell | pmid:15643073 |
| Min J et al. | Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs. | 2004 | Eukaryotic Cell | pmid:15190000 |
| Young KW et al. | Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells. | 2000 | Eur. J. Pharmacol. | pmid:10940357 |
| Cattaneo MG et al. | Oxytocin stimulates in vitro angiogenesis via a Pyk-2/Src-dependent mechanism. | 2009 | Exp. Cell Res. | pmid:19563802 |
| Duan HF et al. | Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. | 2004 | Exp. Cell Res. | pmid:15265705 |
| Park HW et al. | Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells. | 2004 | Exp. Mol. Med. | pmid:15557813 |
| Kaneider NC et al. | The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. | 2004 | FASEB J. | pmid:15208267 |
| Gude DR et al. | Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. | 2008 | FASEB J. | pmid:18362204 |
| Sakakura C et al. | Suppression of bcl-2 gene expression by sphingosine in the apoptosis of human leukemic HL-60 cells during phorbol ester-induced terminal differentiation. | 1996 | FEBS Lett. | pmid:8635587 |
| Masamune A et al. | N,N,N-trimethylsphingosine inhibits interleukin-1 beta-induced NF-kappa B activation and consequent E-selectin expression in human umbilical vein endothelial cells. | 1995 | FEBS Lett. | pmid:7540991 |
| Alemany R et al. | Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. | 2001 | FEBS Lett. | pmid:11741596 |
| Coatrieux C et al. | MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. | 2007 | Free Radic. Biol. Med. | pmid:17561096 |
| Chandru H and Boggaram V | The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells. | 2007 | Gene | pmid:17306937 |
| Kolmakova A et al. | VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo. | 2009 | Glycoconj. J. | pmid:19219548 |
| Zheng XD et al. | Role of Sphk1 in the malignant transformation of breast epithelial cells and breast cancer progression. | 2014 Oct-Dec | Indian J Cancer | pmid:26842184 |
| Liu SQ et al. | Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways. | 2012 | Int J Colorectal Dis | pmid:22684547 |
| Sweeney EA et al. | Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. | 1996 | Int. J. Cancer | pmid:8621258 |
| Hollander MC et al. | Activation of Gadd34 by diverse apoptotic signals and suppression of its growth inhibitory effects by apoptotic inhibitors. | 2001 | Int. J. Cancer | pmid:11241327 |
| Piccolini VM et al. | Cerebellum neurotransmission during postnatal development: [Pt(O,O'-acac)(γ-acac)(DMS)] vs cisplatin and neurotoxicity. | 2015 | Int. J. Dev. Neurosci. | pmid:25450526 |
| Chen K et al. | DMS triggers apoptosis associated with the inhibition of SPHK1/NF-κB activation and increase in intracellular Ca2+ concentration in human cancer cells. | 2014 | Int. J. Mol. Med. | pmid:24173614 |
| Maines LW et al. | Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17065523 |
| Johnson CH et al. | Alterations in Spinal Cord Metabolism during Treatment of Neuropathic Pain. | 2015 | J Neuroimmune Pharmacol | pmid:26232265 |
| Uemura K et al. | Inhibition of neurite outgrowth in neuroblastoma cells by sphingosine. | 1993 | J. Biochem. | pmid:8276777 |
| Yang L et al. | Sphingosine 1-phosphate formation and intracellular Ca2+ mobilization in human platelets: evaluation with sphingosine kinase inhibitors. | 1999 | J. Biochem. | pmid:10393324 |
| Vessey DA et al. | Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17912702 |
| Habrukowich C et al. | Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells. | 2010 | J. Biol. Chem. | pmid:20558741 |
| Nakamura H et al. | Survival by Mac-1-mediated adherence and anoikis in phorbol ester-treated HL-60 cells. | 1998 | J. Biol. Chem. | pmid:9624115 |
| Welsch CA et al. | Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine. | 2004 | J. Biol. Chem. | pmid:15190065 |
| Xia P et al. | Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. | 1999 | J. Biol. Chem. | pmid:10567432 |
| Young KW et al. | Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. | 2000 | J. Biol. Chem. | pmid:10954727 |
| Igarashi Y et al. | A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells. | 1990 | J. Biol. Chem. | pmid:2318819 |
| Megidish T et al. | A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein. | 1998 | J. Biol. Chem. | pmid:9705322 |
| Seko A et al. | Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X. | 2003 | J. Biol. Chem. | pmid:12511560 |
| Cuvillier O et al. | Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. | 2000 | J. Biol. Chem. | pmid:10747891 |
| Liu H et al. | Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. | 2000 | J. Biol. Chem. | pmid:10751414 |
| Ibrahim FB et al. | Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase. | 2004 | J. Biol. Chem. | pmid:15302883 |
| Olivera A et al. | Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. | 1999 | J. Cell Biol. | pmid:10545499 |
| McCaig C et al. | Signalling pathways involved in the direct effects of IGFBP-5 on breast epithelial cell attachment and survival. | 2002 | J. Cell. Biochem. | pmid:11835403 |
| Chuang FY et al. | Convergence of Fc gamma receptor IIA and Fc gamma receptor IIIB signaling pathways in human neutrophils. | 2000 | J. Immunol. | pmid:10605030 |