N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).
Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang H et al. | N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. | 2008 | Mol. Cancer Ther. | pmid:18790777 |
| Kim HL et al. | Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18316219 |
| Kim HL et al. | Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18467142 |
| Jo JY et al. | N,N-Dimethyl-D-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes. | 2008 | J. Pharmacol. Sci. | pmid:18635921 |
| Nagaoka Y et al. | Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells. | 2008 | Biol. Pharm. Bull. | pmid:18520051 |
| Kim HL and Im DS | N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells. | 2008 | Arch. Pharm. Res. | pmid:18277608 |
| Ghosh SC et al. | N,N-dimethylsphingosine-coumarin: synthesis, chemical characterization, and biological evaluation. | 2007 May-Jun | Bioconjug. Chem. | pmid:17432826 |
| Vessey DA et al. | Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. | 2007 | J. Biochem. Mol. Toxicol. | pmid:17912702 |
| Kim HJ et al. | Suppression of osteoclastogenesis by N,N-dimethyl-D-erythro-sphingosine: a sphingosine kinase inhibition-independent action. | 2007 | Mol. Pharmacol. | pmid:17504945 |
| Lee YK et al. | Multiple actions of dimethylsphingosine in 1321N1 astrocytes. | 2007 | Mol. Cells | pmid:17464206 |
| Leroux ME et al. | Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. | 2007 | Prostate | pmid:17879964 |
| Chandru H and Boggaram V | The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells. | 2007 | Gene | pmid:17306937 |
| Coatrieux C et al. | MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. | 2007 | Free Radic. Biol. Med. | pmid:17561096 |
| Jin YX et al. | Sphingosine kinase assay system with fluorescent detection in high performance liquid chromatography. | 2006 | Arch. Pharm. Res. | pmid:17146975 |
| Chang YJ et al. | Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line. | 2006 | Arch. Pharm. Res. | pmid:16964761 |
| Jin ZQ and Karliner JS | Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism. | 2006 | Cardiovasc. Res. | pmid:16831409 |
| Zhang YH et al. | Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons. | 2006 | J. Physiol. (Lond.) | pmid:16740613 |
| Lee YK et al. | Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16904073 |
| Lee EH et al. | Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes. | 2006 | J. Pharmacol. Sci. | pmid:16575153 |
| Maines LW et al. | Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. | 2006 | Invest. Ophthalmol. Vis. Sci. | pmid:17065523 |
| Min J et al. | Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin. | 2005 | Eukaryotic Cell | pmid:15643073 |
| Billich A et al. | Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. | 2005 | Cell. Signal. | pmid:16038795 |
| Saini HS et al. | Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. | 2005 | J. Neurochem. | pmid:16313513 |
| Ohmori T et al. | The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets. | 2005 | Thromb. Res. | pmid:15733975 |
| Meacci E et al. | Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts. | 2004 | Biochem. J. | pmid:15109308 |
| Park HW et al. | Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells. | 2004 | Exp. Mol. Med. | pmid:15557813 |
| Jin ZQ et al. | Sphingosine kinase activation mediates ischemic preconditioning in murine heart. | 2004 | Circulation | pmid:15451787 |
| Worgall TS et al. | Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15132973 |
| Welsch CA et al. | Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine. | 2004 | J. Biol. Chem. | pmid:15190065 |
| Kaneider NC et al. | The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. | 2004 | FASEB J. | pmid:15208267 |
| Van IJzendoorn SC et al. | Polarized membrane traffic and cell polarity development is dependent on dihydroceramide synthase-regulated sphinganine turnover. | 2004 | Mol. Biol. Cell | pmid:15229289 |
| Roth Z and Hansen PJ | Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. | 2004 | Biol. Reprod. | pmid:15317688 |
| Min J et al. | Overexpression of sphingosine-1-phosphate lyase or inhibition of sphingosine kinase in Dictyostelium discoideum results in a selective increase in sensitivity to platinum-based chemotherapy drugs. | 2004 | Eukaryotic Cell | pmid:15190000 |
| Ibrahim FB et al. | Anaphylatoxin signaling in human neutrophils. A key role for sphingosine kinase. | 2004 | J. Biol. Chem. | pmid:15302883 |
| Kaneider NC et al. | Heparan sulfate proteoglycans are involved in opiate receptor-mediated cell migration. | 2004 | Biochemistry | pmid:14705951 |
| Duan HF et al. | Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. | 2004 | Exp. Cell Res. | pmid:15265705 |
| Alfonso A et al. | Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes. | 2003 | Biochem. Pharmacol. | pmid:12527340 |
| Seko A et al. | Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X. | 2003 | J. Biol. Chem. | pmid:12511560 |
| Kaneider NC et al. | Leukocyte motility in response to neuropeptides is heparan sulfate proteoglycan dependent. | 2003 | Peptides | pmid:12895655 |
| MacKinnon AC et al. | Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. | 2002 | J. Immunol. | pmid:12444147 |
| Hanafusa N et al. | Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. | 2002 | Nephrol. Dial. Transplant. | pmid:11917049 |
| McCaig C et al. | Signalling pathways involved in the direct effects of IGFBP-5 on breast epithelial cell attachment and survival. | 2002 | J. Cell. Biochem. | pmid:11835403 |
| Pallis M | Sphingosine kinase inhibitors in the apoptosis of leukaemia cells. | 2002 | Leuk. Res. | pmid:11839389 |
| Jendiroba DB et al. | Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine. | 2002 | Leuk. Res. | pmid:11792420 |
| Ren J et al. | Expression of sphingosine kinase gene in the interactions between human gastric carcinoma cell and vascular endothelial cell. | 2002 | World J. Gastroenterol. | pmid:12174364 |
| Xu CB et al. | D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. | 2002 | Atherosclerosis | pmid:12204793 |
| Cuvillier O and Levade T | Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. | 2001 | Blood | pmid:11675357 |
| Manggau M et al. | 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. | 2001 | J. Invest. Dermatol. | pmid:11710939 |
| Alfonso A et al. | Prolactin induces calcium influx and release from intracellular pools in human T lymphocytes by activation of tyrosine kinases. | 2001 | Cell. Signal. | pmid:11583917 |
| Alemany R et al. | Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. | 2001 | FEBS Lett. | pmid:11741596 |