N,N-dimethylsphingosine

N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.

Cross Reference

Introduction

To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N,N-dimethylsphingosine?

N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Asthma D001249 52 associated lipids
Proteinuria D011507 30 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Trypanosomiasis, African D014353 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with N,N-dimethylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with N,N-dimethylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:

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What genes are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N,N-dimethylsphingosine?

Mouse Model

Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).

Knock-out

Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with N,N-dimethylsphingosine

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Authors Title Published Journal PubMed Link
Osawa Y et al. Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor. 2001 Biochem. Biophys. Res. Commun. pmid:11520048
Caldwell C et al. Regulatory differences among avian ecto-ATPases. 1997 Biochem. Biophys. Res. Commun. pmid:9325157
Yatomi Y et al. N,N-dimethylsphingosine phosphorylation in human platelets. 1997 Biochem. Biophys. Res. Commun. pmid:9070908
Meacci E et al. Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts. 2004 Biochem. J. pmid:15109308
Banno Y et al. Evidence for the presence of multiple forms of Sph kinase in human platelets. 1998 Biochem. J. pmid:9761727
Young KW et al. Lysophosphatidic acid-mediated Ca2+ mobilization in human SH-SY5Y neuroblastoma cells is independent of phosphoinositide signalling, but dependent on sphingosine kinase activation. 1999 Biochem. J. pmid:10493910
Kim YK et al. Differential regulation of protein tyrosine kinase on free radical production, granule enzyme release, and cytokine synthesis by activated murine peritoneal macrophages. 2001 Biochem. Pharmacol. pmid:11137713
Alfonso A et al. Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes. 2003 Biochem. Pharmacol. pmid:12527340
Edsall LC et al. N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. 1998 Biochemistry pmid:9737868
Yatomi Y et al. N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets. 1996 Biochemistry pmid:8555236