N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).
Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| MacKinnon AC et al. | Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. | 2002 | J. Immunol. | pmid:12444147 |
| Osawa Y et al. | TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. | 2001 | J. Immunol. | pmid:11418646 |
| Lai WQ et al. | The role of sphingosine kinase in a murine model of allergic asthma. | 2008 | J. Immunol. | pmid:18322246 |
| Lai WQ et al. | Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis. | 2008 | J. Immunol. | pmid:19017993 |
| Manggau M et al. | 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. | 2001 | J. Invest. Dermatol. | pmid:11710939 |
| Walev I et al. | Streptolysin O-permeabilized granulocytes shed L-selectin concomitantly with ceramide generation via neutral sphingomyelinase. | 2000 | J. Leukoc. Biol. | pmid:11129654 |
| Wong L et al. | Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. | 2009 | J. Med. Chem. | pmid:19469544 |
| Sun D and Hurley LH | The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression. | 2009 | J. Med. Chem. | pmid:19385599 |
| Karliner JS et al. | The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. | 2001 | J. Mol. Cell. Cardiol. | pmid:11549349 |
| Asle-Rousta M et al. | Prominence of central sphingosine-1-phosphate receptor-1 in attenuating aβ-induced injury by fingolimod. | 2014 | J. Mol. Neurosci. | pmid:25239520 |
| Saini HS et al. | Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. | 2005 | J. Neurochem. | pmid:16313513 |
| Edsall LC et al. | Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. | 2001 | J. Neurochem. | pmid:11238741 |
| Jo JY et al. | N,N-Dimethyl-D-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes. | 2008 | J. Pharmacol. Sci. | pmid:18635921 |
| Lee EH et al. | Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes. | 2006 | J. Pharmacol. Sci. | pmid:16575153 |
| Zhang YH et al. | Brain-derived neurotrophic factor enhances the excitability of rat sensory neurons through activation of the p75 neurotrophin receptor and the sphingomyelin pathway. | 2008 | J. Physiol. (Lond.) | pmid:18450779 |
| Zhang YH et al. | Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons. | 2006 | J. Physiol. (Lond.) | pmid:16740613 |
| Chan L | Harnessing regulatory T cells for therapeutic purposes. | 2012 | Kidney Int. | pmid:22543901 |
| Lai LW et al. | Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury. | 2012 | Kidney Int. | pmid:22189844 |
| Pallis M | Sphingosine kinase inhibitors in the apoptosis of leukaemia cells. | 2002 | Leuk. Res. | pmid:11839389 |
| Jendiroba DB et al. | Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine. | 2002 | Leuk. Res. | pmid:11792420 |
| Kanno T and Nishizaki T | Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors. | 2011 | Life Sci. | pmid:21683714 |
| Van IJzendoorn SC et al. | Polarized membrane traffic and cell polarity development is dependent on dihydroceramide synthase-regulated sphinganine turnover. | 2004 | Mol. Biol. Cell | pmid:15229289 |
| Wang H et al. | N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. | 2008 | Mol. Cancer Ther. | pmid:18790777 |
| Lee YK et al. | Multiple actions of dimethylsphingosine in 1321N1 astrocytes. | 2007 | Mol. Cells | pmid:17464206 |
| Nam JH et al. | Sphingosine and FTY720 modulate pacemaking activity in interstitial cells of Cajal from mouse small intestine. | 2013 | Mol. Cells | pmid:23912597 |
| Lan T et al. | Sphingosine kinase-1 pathway mediates high glucose-induced fibronectin expression in glomerular mesangial cells. | 2011 | Mol. Endocrinol. | pmid:21998146 |
| Kim HJ et al. | Suppression of osteoclastogenesis by N,N-dimethyl-D-erythro-sphingosine: a sphingosine kinase inhibition-independent action. | 2007 | Mol. Pharmacol. | pmid:17504945 |
| Trifilieff A et al. | Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19636535 |
| Hanafusa N et al. | Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. | 2002 | Nephrol. Dial. Transplant. | pmid:11917049 |
| Chen YJ et al. | Inflammation triggers production of dimethylsphingosine from oligodendrocytes. | 2014 | Neuroscience | pmid:25151189 |
| Kaneider NC et al. | Leukocyte motility in response to neuropeptides is heparan sulfate proteoglycan dependent. | 2003 | Peptides | pmid:12895655 |
| Xia P et al. | Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9826677 |
| Kim HL et al. | Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18316219 |
| Kim HL et al. | Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18467142 |
| Leroux ME et al. | Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. | 2007 | Prostate | pmid:17879964 |
| Kono Y et al. | Sphingosine kinase 1 regulates mucin production via ERK phosphorylation. | 2010 | Pulm Pharmacol Ther | pmid:19835973 |
| Hobson JP et al. | Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. | 2001 | Science | pmid:11230698 |
| Itagaki K et al. | Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils. | 2010 | Shock | pmid:19851125 |
| Leitzke AS et al. | Isoflurane post-treatment ameliorates GMH-induced brain injury in neonatal rats. | 2013 | Stroke | pmid:24149004 |
| Igarashi Y | [Bioregulatory functions of methylsphingosines: in relation to sphingolipid signaling pathway and on approach of introducing sphingolipid-based drugs]. | 1998 | Tanpakushitsu Kakusan Koso | pmid:9528354 |
| Ohmori T et al. | The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets. | 2005 | Thromb. Res. | pmid:15733975 |
| Okamoto H et al. | Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration. | 2000 | Thromb. Res. | pmid:10942792 |
| Zhang Z et al. | SPHK1 inhibitor suppresses cell proliferation and invasion associated with the inhibition of NF-κB pathway in hepatocellular carcinoma. | 2015 | Tumour Biol. | pmid:25537088 |
| Ren J et al. | Expression of sphingosine kinase gene in the interactions between human gastric carcinoma cell and vascular endothelial cell. | 2002 | World J. Gastroenterol. | pmid:12174364 |
| Lei YC et al. | Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells. | 2015 | World J. Gastroenterol. | pmid:26676341 |
| Yu HM et al. | [Regulation of sphingosine kinase 1 in the TNF-α-induced expression of MUC5AC in airway epithelial cells]. | 2011 | Zhonghua Yi Xue Za Zhi | pmid:21418911 |
| Yin GJ et al. | [Antitumor effect of sphingosine kinase 1 inhibitor in combination with chemotherapy on SGC7901 gastric cancer cells in vitro]. | 2012 | Zhonghua Zhong Liu Za Zhi | pmid:22780925 |
| Liu SQ et al. | [Sphingosine kinase 1 enhances the proliferation and invasion of human colon cancer LoVo cells through up-regulating FAK pathway and the expression of ICAM-1 and VCAM-1]. | 2013 | Zhonghua Zhong Liu Za Zhi | pmid:24054007 |
| Liu SQ et al. | [Effect of sphingosine kinase 1 on the apoptosis, migration and invasion of colon cancer HT-29 cells and its molecular mechanisms]. | 2011 | Zhonghua Zhong Liu Za Zhi | pmid:21575515 |