N,N-dimethylsphingosine

N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.

Cross Reference

Introduction

To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with N,N-dimethylsphingosine?

N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Asthma D001249 52 associated lipids
Proteinuria D011507 30 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Carcinoma, Lewis Lung D018827 22 associated lipids
Trypanosomiasis, African D014353 5 associated lipids
Total 8

PubChem Associated disorders and diseases

What pathways are associated with N,N-dimethylsphingosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with N,N-dimethylsphingosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:

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What genes are associated with N,N-dimethylsphingosine?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with N,N-dimethylsphingosine?

Mouse Model

Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).

Knock-out

Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with N,N-dimethylsphingosine

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Authors Title Published Journal PubMed Link
Qu W et al. Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation. 2009 Bioorg. Med. Chem. Lett. pmid:19467599
De Jonghe S et al. Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase. 1999 Bioorg. Med. Chem. Lett. pmid:10560747
Cuvillier O and Levade T Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. 2001 Blood pmid:11675357
Smith JJ et al. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. 2009 BMC Syst Biol pmid:19284563
Qin X et al. Sphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels. 2013 Br. J. Pharmacol. pmid:23145923
McDonald RA et al. The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia. 2010 Br. J. Pharmacol. pmid:20015089
Camaré C et al. Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. 2015 Br. J. Pharmacol. pmid:25176316
Shinpo K et al. Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. 1999 Brain Res. pmid:10082875
Okoshi H et al. Cell membrane signaling as target in cancer therapy. II: Inhibitory effect of N,N,N-trimethylsphingosine on metastatic potential of murine B16 melanoma cell line through blocking of tumor cell-dependent platelet aggregation. 1991 Cancer Res. pmid:1657377
Nava VE et al. Sphingosine enhances apoptosis of radiation-resistant prostate cancer cells. 2000 Cancer Res. pmid:10969794