N,N-dimethylsphingosine is a lipid of Sphingolipids (SP) class. N,n-dimethylsphingosine is associated with abnormalities such as Exanthema and Increased drug resistance. The involved functions are known as Vmax, Metabolic Inhibition, Anabolism, Binding (Molecular Function) and Cytokinesis. N,n-dimethylsphingosine often locates in yolk, Membrane, CNS - Brain (MMHCC), soluble and Tissue membrane. The associated genes with N,N-dimethylsphingosine are FPR1 gene, ANP32A gene, HPGDS gene, Nuclear phosphoprotein and PTGS2 gene. The related lipids are Sphingolipids, Phosphatidic Acid, Lysophosphatidylcholines, stearylamine and dihydroceramide. The related experimental models are Mouse Model and Knock-out.
To understand associated biological information of N,N-dimethylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N,N-dimethylsphingosine is suspected in Exanthema, Increased drug resistance and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with N,N-dimethylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Trypanosomiasis, African | D014353 | 5 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Sphingosine interaction with acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) regulates PP2A activity and cyclooxygenase (COX)-2 expression in human endothelial cells.' (Habrukowich C et al., 2010).
Knock-out are used in the study 'Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.' (Jin ZQ and Karliner JS, 2006).
| Model | Cross reference | Weighted score | Related literatures |
|---|
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Meacci E et al. | Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts. | 2004 | Biochem. J. | pmid:15109308 |
| Park HW et al. | Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells. | 2004 | Exp. Mol. Med. | pmid:15557813 |
| Kaneider NC et al. | The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor. | 2004 | FASEB J. | pmid:15208267 |
| Roth Z and Hansen PJ | Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. | 2004 | Biol. Reprod. | pmid:15317688 |
| Kaneider NC et al. | Heparan sulfate proteoglycans are involved in opiate receptor-mediated cell migration. | 2004 | Biochemistry | pmid:14705951 |
| Duan HF et al. | Sphingosine kinase activation regulates hepatocyte growth factor induced migration of endothelial cells. | 2004 | Exp. Cell Res. | pmid:15265705 |
| Alfonso A et al. | Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes. | 2003 | Biochem. Pharmacol. | pmid:12527340 |
| Seko A et al. | Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X. | 2003 | J. Biol. Chem. | pmid:12511560 |
| Kaneider NC et al. | Leukocyte motility in response to neuropeptides is heparan sulfate proteoglycan dependent. | 2003 | Peptides | pmid:12895655 |
| MacKinnon AC et al. | Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. | 2002 | J. Immunol. | pmid:12444147 |
| Hanafusa N et al. | Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. | 2002 | Nephrol. Dial. Transplant. | pmid:11917049 |
| McCaig C et al. | Signalling pathways involved in the direct effects of IGFBP-5 on breast epithelial cell attachment and survival. | 2002 | J. Cell. Biochem. | pmid:11835403 |
| Pallis M | Sphingosine kinase inhibitors in the apoptosis of leukaemia cells. | 2002 | Leuk. Res. | pmid:11839389 |
| Jendiroba DB et al. | Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine. | 2002 | Leuk. Res. | pmid:11792420 |
| Ren J et al. | Expression of sphingosine kinase gene in the interactions between human gastric carcinoma cell and vascular endothelial cell. | 2002 | World J. Gastroenterol. | pmid:12174364 |
| Xu CB et al. | D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. | 2002 | Atherosclerosis | pmid:12204793 |
| Osawa Y et al. | TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. | 2001 | J. Immunol. | pmid:11418646 |
| Cuvillier O and Levade T | Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. | 2001 | Blood | pmid:11675357 |
| Manggau M et al. | 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. | 2001 | J. Invest. Dermatol. | pmid:11710939 |
| Alemany R et al. | Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. | 2001 | FEBS Lett. | pmid:11741596 |