fumonisin b1

fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.

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Introduction

To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with fumonisin b1?

fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with fumonisin b1

MeSH term MeSH ID Detail
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Adenoma, Liver Cell D018248 2 associated lipids
Neuroectodermal Tumors, Primitive, Peripheral D018241 3 associated lipids
Weight Gain D015430 101 associated lipids
Testicular Diseases D013733 15 associated lipids
Swine Diseases D013553 16 associated lipids
Stomatitis D013280 14 associated lipids
Stomach Ulcer D013276 75 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Per page 10 20 50 100 | Total 54

PubChem Associated disorders and diseases

What pathways are associated with fumonisin b1

Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with fumonisin b1?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with fumonisin b1?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with fumonisin b1?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with fumonisin b1?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with fumonisin b1?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with fumonisin b1

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Per page 10 20 50 100 | Total 1278
Authors Title Published Journal PubMed Link
Harvey B et al. Toxicity of fumonisin from Fusarium verticillioides culture material and moniliformin from Fusarium fujikuroi culture material when fed singly and in combination to growing barrows. 2002 J. Food Prot. pmid:11848570
Avantaggiato G et al. Effects of muffin processing on fumonisins from 14C-labeled toxins produced in cultured corn kernels. 2003 J. Food Prot. pmid:14572226
De Girolamo A et al. Effect of processing on fumonisin concentration in corn flakes. 2001 J. Food Prot. pmid:11348004
Seo E et al. Fumonisins B1 and B2 in agricultural products consumed in South Korea: an exposure assessment. 2009 J. Food Prot. pmid:19350995
Feng YZ et al. Natural occurrence of fumonisins b1 and b2 in corn from three main production provinces in China. 2011 J. Food Prot. pmid:21819670
Castelo MM et al. Occurrence of fumonisins in corn-based food products. 1998 J. Food Prot. pmid:9709253
Castelo MM et al. Stability of fumonisins in thermally processed corn products. 1998 J. Food Prot. pmid:9713766
Ariño A et al. Natural occurrence of Fusarium species, fumonisin production by toxigenic strains, and concentrations of fumonisins B1, and B2 in conventional and organic maize grown in Spain. 2007 J. Food Prot. pmid:17265874
Gutema T et al. Occurrence of fumonisins and moniliformin in corn and corn-based food products of U.S. origin. 2000 J. Food Prot. pmid:11131899
Magembe KS et al. Mycotoxin Contamination in Stored Maize and Groundnuts Based on Storage Practices and Conditions in Subhumid Tropical Africa: The Case of Kilosa District, Tanzania. 2016 J. Food Prot. pmid:28221960
Shim WB et al. Comparison of fumonisin B1 biosynthesis in maize germ and degermed kernels by Fusarium verticillioides. 2003 J. Food Prot. pmid:14627291
Tonnetti L et al. A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction. 1999 J. Exp. Med. pmid:10330437
Zhang X et al. Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4. 2015 J. Exp. Bot. pmid:25788731
Palyusik M and Moran EM Porcine pulmonary edema with hydrothorax: a review. 1994 J. Environ. Pathol. Toxicol. Oncol. pmid:7823296
Wang H et al. The fumonisin B1 content in corn from North China, a high-risk area of esophageal cancer. 2000 J. Environ. Pathol. Toxicol. Oncol. pmid:10905519
Coulombe RA Biological action of mycotoxins. 1993 J. Dairy Sci. pmid:8463495
Schmidt P et al. Concentration of mycotoxins and chemical composition of corn silage: a farm survey using infrared thermography. 2015 J. Dairy Sci. pmid:26162792
Sharma RP et al. Demonstration of in-situ apoptosis in mouse liver and kidney after short-term repeated exposure to fumonisin B1. 1997 J. Comp. Pathol. pmid:9502273
Suomalainen L et al. Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis. 2003 J. Clin. Endocrinol. Metab. pmid:14602806
Shetty PH and Bhat RV Sensitive method for the detection of fumonisin B1 in human urine. 1998 J. Chromatogr. B Biomed. Sci. Appl. pmid:9498687
Tardieu D et al. Determination of Fumonisin B1 in animal tissues with immunoaffinity purification. 2008 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:18571484
Li L et al. Development of immune-affinity 96 spots monolith array for multiple mycotoxins detection in food samples. 2016 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:27423670
Pagliuca G et al. Simple method for the simultaneous isolation and determination of fumonisin B1 and its metabolite aminopentol-1 in swine liver by liquid chromatography--fluorescence detection. 2005 J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. pmid:15797527
Shephard GS et al. Determination of fumonisin B1 in plasma and urine by high-performance liquid chromatography. 1992 J. Chromatogr. pmid:1618963
Sauane M et al. Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis. 2010 J. Cell. Physiol. pmid:19937735
Le Stunff H et al. Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. 2002 J. Cell Biol. pmid:12235122
Mays RW et al. Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells. 1995 J. Cell Biol. pmid:7657695
Heinl S et al. Degradation of fumonisin B1 by the consecutive action of two bacterial enzymes. 2010 J. Biotechnol. pmid:19922747
Kuroyanagi M et al. Vacuolar processing enzyme is essential for mycotoxin-induced cell death in Arabidopsis thaliana. 2005 J. Biol. Chem. pmid:16043487
Chalfant CE et al. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. 2002 J. Biol. Chem. pmid:11801602
Kroesen BJ et al. Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. 2001 J. Biol. Chem. pmid:11278517
Stevens VL and Tang J Fumonisin B1-induced sphingolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinositol-anchored folate receptor. 1997 J. Biol. Chem. pmid:9218430
Jenkins GM et al. Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins. 2002 J. Biol. Chem. pmid:12200446
Wang E et al. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. 1991 J. Biol. Chem. pmid:1860857
Zitomer NC et al. Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals. 2009 J. Biol. Chem. pmid:19095642
Hinkovska-Galcheva V et al. Enhanced phagocytosis through inhibition of de novo ceramide synthesis. 2003 J. Biol. Chem. pmid:12424251
Wieder T et al. Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine. 1998 J. Biol. Chem. pmid:9556584
Sofer A and Futerman AH Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP. 1995 J. Biol. Chem. pmid:7744860
Jarvis WD et al. Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. 1996 J. Biol. Chem. pmid:8626522
Merrill AH et al. Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. 1995 J. Biol. Chem. pmid:7775441
Penno A et al. Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. 2010 J. Biol. Chem. pmid:20097765
Riebeling C et al. Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 2003 J. Biol. Chem. pmid:12912983
Zhang Y et al. The mycotoxin fumonisin B1 transcriptionally activates the p21 promoter through a cis-acting element containing two Sp1 binding sites. 1999 J. Biol. Chem. pmid:10212208
Schwarz A et al. A regulatory role for sphingolipids in neuronal growth. Inhibition of sphingolipid synthesis and degradation have opposite effects on axonal branching. 1995 J. Biol. Chem. pmid:7738041
Kitatani K et al. Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. 2007 J. Biol. Chem. pmid:17504762
Hidari KIPJ S et al. Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells. 1996 J. Biol. Chem. pmid:8662871
Becker KP et al. Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. 2005 J. Biol. Chem. pmid:15546881
Cuvillier O et al. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. 2000 J. Biol. Chem. pmid:10747891
Mao C et al. Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. 2000 J. Biol. Chem. pmid:10702247
Hernández-Corbacho MJ et al. Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. 2015 J. Biol. Chem. pmid:26318452