fumonisin b1

fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.

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Introduction

To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with fumonisin b1?

fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with fumonisin b1

MeSH term MeSH ID Detail
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Adenoma, Liver Cell D018248 2 associated lipids
Neuroectodermal Tumors, Primitive, Peripheral D018241 3 associated lipids
Weight Gain D015430 101 associated lipids
Testicular Diseases D013733 15 associated lipids
Swine Diseases D013553 16 associated lipids
Stomatitis D013280 14 associated lipids
Stomach Ulcer D013276 75 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Per page 10 20 50 100 | Total 54

PubChem Associated disorders and diseases

What pathways are associated with fumonisin b1

Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with fumonisin b1?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with fumonisin b1?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with fumonisin b1?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with fumonisin b1?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with fumonisin b1?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with fumonisin b1

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Per page 10 20 50 100 | Total 1278
Authors Title Published Journal PubMed Link
Jenkins GR et al. Identification of fumonisin B1 as an inhibitor of argininosuccinate synthetase using fumonisin affinity chromatography and in vitro kinetic studies. 2000 J. Biochem. Mol. Toxicol. pmid:11083085
Kang YJ and Alexander JM Alterations of the glutathione redox cycle status in fumonisin B1-treated pig kidney cells. 1996 J. Biochem. Toxicol. pmid:9029270
El Bawab S et al. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. 2001 J. Biol. Chem. pmid:11278489
Meivar-Levy I and Futerman AH Up-regulation of neutral glycosphingolipid synthesis upon long term inhibition of ceramide synthesis by fumonisin B1. 1999 J. Biol. Chem. pmid:9988695
Chalfant CE et al. FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1. 2001 J. Biol. Chem. pmid:11502750
Okino N et al. The reverse activity of human acid ceramidase. 2003 J. Biol. Chem. pmid:12764132
Lefrancois S et al. The lysosomal transport of prosaposin requires the conditional interaction of its highly conserved d domain with sphingomyelin. 2002 J. Biol. Chem. pmid:11856752
Kuroyanagi M et al. Vacuolar processing enzyme is essential for mycotoxin-induced cell death in Arabidopsis thaliana. 2005 J. Biol. Chem. pmid:16043487
Chalfant CE et al. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. 2002 J. Biol. Chem. pmid:11801602
Le Stunff H et al. Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. 2004 J. Biol. Chem. pmid:15180992
Kroesen BJ et al. Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. 2001 J. Biol. Chem. pmid:11278517
Stevens VL and Tang J Fumonisin B1-induced sphingolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinositol-anchored folate receptor. 1997 J. Biol. Chem. pmid:9218430
Mullen TD et al. Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. 2011 J. Biol. Chem. pmid:21388949
Meivar-Levy I et al. The role of sphingolipids in the maintenance of fibroblast morphology. The inhibition of protrusional activity, cell spreading, and cytokinesis induced by fumonisin B1 can be reversed by ganglioside GM3. 1997 J. Biol. Chem. pmid:8999828
de Chaves EI et al. Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons. 1997 J. Biol. Chem. pmid:9006952
Jenkins GM et al. Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins. 2002 J. Biol. Chem. pmid:12200446
Wiesner DA et al. Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by bcl-XL. 1997 J. Biol. Chem. pmid:9092523
Venkataraman K et al. Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells. 2002 J. Biol. Chem. pmid:12105227
Wang E et al. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. 1991 J. Biol. Chem. pmid:1860857
Zitomer NC et al. Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals. 2009 J. Biol. Chem. pmid:19095642
Hinkovska-Galcheva V et al. Enhanced phagocytosis through inhibition of de novo ceramide synthesis. 2003 J. Biol. Chem. pmid:12424251
Nieto FL et al. Sphingolipid metabolism is a crucial determinant of cellular fate in nonstimulated proliferating Madin-Darby canine kidney (MDCK) cells. 2008 J. Biol. Chem. pmid:18625703
Wieder T et al. Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine. 1998 J. Biol. Chem. pmid:9556584
Le Stunff H et al. Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. 2007 J. Biol. Chem. pmid:17895250
Sofer A and Futerman AH Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP. 1995 J. Biol. Chem. pmid:7744860
Wu WI et al. Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1. 1995 J. Biol. Chem. pmid:7768913
Strum JC et al. Ceramide triggers meiotic cell cycle progression in Xenopus oocytes. A potential mediator of progesterone-induced maturation. 1995 J. Biol. Chem. pmid:7768956
Jarvis WD et al. Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. 1996 J. Biol. Chem. pmid:8626522
Merrill AH et al. Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. 1995 J. Biol. Chem. pmid:7775441
Penno A et al. Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. 2010 J. Biol. Chem. pmid:20097765
Riebeling C et al. Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 2003 J. Biol. Chem. pmid:12912983
Harel R and Futerman AH Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons. 1993 J. Biol. Chem. pmid:8314804
Zhang Y et al. The mycotoxin fumonisin B1 transcriptionally activates the p21 promoter through a cis-acting element containing two Sp1 binding sites. 1999 J. Biol. Chem. pmid:10212208
Kim WY et al. Inhibitor of apoptosis (IAP)-like protein lacks a baculovirus IAP repeat (BIR) domain and attenuates cell death in plant and animal systems. 2011 J. Biol. Chem. pmid:21926169
Schwarz A et al. A regulatory role for sphingolipids in neuronal growth. Inhibition of sphingolipid synthesis and degradation have opposite effects on axonal branching. 1995 J. Biol. Chem. pmid:7738041
Kitatani K et al. Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. 2007 J. Biol. Chem. pmid:17504762
Tsegaye Y et al. Arabidopsis mutants lacking long chain base phosphate lyase are fumonisin-sensitive and accumulate trihydroxy-18:1 long chain base phosphate. 2007 J. Biol. Chem. pmid:17635905
Schroeder JJ et al. Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme. 1994 J. Biol. Chem. pmid:8106389
Williamson LC et al. Neuronal sensitivity to tetanus toxin requires gangliosides. 1999 J. Biol. Chem. pmid:10455200
Liao WC et al. Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. 1999 J. Biol. Chem. pmid:10364237
Humpf HU et al. Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. 1998 J. Biol. Chem. pmid:9668088
Hidari KIPJ S et al. Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells. 1996 J. Biol. Chem. pmid:8662871
Schmidt K et al. Regulated apical secretion of zymogens in rat pancreas. Involvement of the glycosylphosphatidylinositol-anchored glycoprotein GP-2, the lectin ZG16p, and cholesterol-glycosphingolipid-enriched microdomains. 2001 J. Biol. Chem. pmid:11152672
Becker KP et al. Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. 2005 J. Biol. Chem. pmid:15546881
Balsinde J et al. Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis. 1997 J. Biol. Chem. pmid:9252342
Cuvillier O et al. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. 2000 J. Biol. Chem. pmid:10747891
Mao C et al. Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. 2000 J. Biol. Chem. pmid:10702247
Merrill AH et al. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. 1993 J. Biol. Chem. pmid:8262970
Schulz A et al. The CLN9 protein, a regulator of dihydroceramide synthase. 2006 J. Biol. Chem. pmid:16303764
Hernández-Corbacho MJ et al. Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. 2015 J. Biol. Chem. pmid:26318452