fumonisin b1

fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.

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Introduction

To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with fumonisin b1?

fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with fumonisin b1

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Adenoma D000236 40 associated lipids
Asthma D001249 52 associated lipids
Body Weight D001835 333 associated lipids
Brain Diseases D001927 27 associated lipids
Carcinoma D002277 18 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Choline Deficiency D002796 16 associated lipids
Cleft Palate D002972 9 associated lipids
Death, Sudden D003645 12 associated lipids
Esophageal Neoplasms D004938 20 associated lipids
Fatty Liver D005234 48 associated lipids
Fetal Resorption D005327 15 associated lipids
Gaucher Disease D005776 13 associated lipids
Glioblastoma D005909 27 associated lipids
Glioma D005910 112 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hydrocephalus D006849 6 associated lipids
Hyperplasia D006965 34 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with fumonisin b1

Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with fumonisin b1?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with fumonisin b1?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with fumonisin b1?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with fumonisin b1?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with fumonisin b1?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with fumonisin b1

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Per page 10 20 50 100 | Total 1278
Authors Title Published Journal PubMed Link
Osuchowski MF and Sharma RP Fumonisin B1 induces necrotic cell death in BV-2 cells and murine cultured astrocytes and is antiproliferative in BV-2 cells while N2A cells and primary cortical neurons are resistant. 2005 Neurotoxicology pmid:16005069
Saucedo-García M et al. MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. 2011 New Phytol. pmid:21534970
Wolf G Inhibition of cellular uptake of folate by blocking synthesis of the membrane folate receptor. 1998 Nutr. Rev. pmid:9564182
Wolf G Mechanism of the mitogenic and carcinogenic action of fumonisin B1, a mycotoxin. 1994 Nutr. Rev. pmid:8090377
White-Gilbertson S et al. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. 2009 Oncogene pmid:19137010
Kellerman TS et al. Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. 1990 Onderstepoort J. Vet. Res. pmid:2293136
Marasas WF et al. Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. 1988 Onderstepoort J. Vet. Res. pmid:3217091
Hwang D et al. Effects of ceramide inhibition on experimental radiation-induced oral mucositis. 2005 Oral Surg Oral Med Oral Pathol Oral Radiol Endod pmid:16122660
Nogueira TC et al. Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion. 2008 Pancreas pmid:18815554
Mazzoni E et al. Field control of Fusarium ear rot, Ostrinia nubilalis (Hübner), and fumonisins in maize kernels. 2011 Pest Manag. Sci. pmid:21394878
Demirel G et al. Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells. 2015 Pharm Biol pmid:25858139
Eichele K et al. R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. 2009 Pharm. Res. pmid:19015962
Atroshi F et al. Fumonisin B1-induced DNA damage in rat liver and spleen: effects of pretreatment with coenzyme Q10, L-carnitine, alpha-tocopherol and selenium. 1999 Pharmacol. Res. pmid:10660942
Atroshi F et al. Effects of tamoxifen, melatonin, coenzyme Q10, and L-carnitine supplementation on bacterial growth in the presence of mycotoxins. 1998 Pharmacol. Res. pmid:9774492
Dutton MF Fumonisins, mycotoxins of increasing importance: their nature and their effects. 1996 Pharmacol. Ther. pmid:8843466
He Q et al. Pharmacological antagonism of fumonisin B1 cytotoxicity in porcine renal epithelial cells (LLC-PK1): a model for reducing fumonisin-induced nephrotoxicity in vivo. 2002 Pharmacol. Toxicol. pmid:12076308
Boppana NB et al. Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization. 2014 Photochem. Photobiol. Sci. pmid:25266739
Szabó A et al. Oral administration of fumonisin B and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits. 2016 Physiol Int pmid:28229635
Abbas HK et al. Biological activities of synthetic analogues of Alternaria alternata toxin (AAL-toxin) and fumonisin in plant and mammalian cell cultures. 1995 Phytochemistry pmid:8590636
Desjardins AE et al. Identification and heritability of fumonisin insensitivity in Zea mays. 2005 Phytochemistry pmid:16198380