| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Kidney Neoplasms | D007680 | 29 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Esophageal Neoplasms | D004938 | 20 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Carcinoma | D002277 | 18 associated lipids |
| Pulmonary Edema | D011654 | 23 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Testicular Diseases | D013733 | 15 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Brain Diseases | D001927 | 27 associated lipids |
| Cardiovascular Diseases | D002318 | 24 associated lipids |
fumonisin b1
fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.
Cross Reference
Introduction
To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with fumonisin b1?
fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Cancer Res. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with fumonisin b1
PubChem Associated disorders and diseases
What pathways are associated with fumonisin b1
Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with fumonisin b1?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with fumonisin b1?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with fumonisin b1?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with fumonisin b1?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with fumonisin b1?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with fumonisin b1
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Masini E et al. | Ceramide: a key signaling molecule in a Guinea pig model of allergic asthmatic response and airway inflammation. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18042827 |
| Hartl M and Humpf HU | Combined synthetic/CD strategy for the stereochemical assignment of the tricarballylic acid side chains of fumonisin B(1). | 2001 | J. Org. Chem. | pmid:11374984 |
| Hamada Y et al. | Involvement of de novo ceramide synthesis in pro-inflammatory adipokine secretion and adipocyte-macrophage interaction. | 2014 | J. Nutr. Biochem. | pmid:25283329 |
| Wang E et al. | Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme. | 1992 | J. Nutr. | pmid:1640265 |
| Riley RT et al. | Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity. | 1994 | J. Nutr. | pmid:8145083 |
| Merrill AH et al. | Role of dietary sphingolipids and inhibitors of sphingolipid metabolism in cancer and other diseases. | 1995 | J. Nutr. | pmid:7782925 |
| Palencia E et al. | Total fumonisins are reduced in tortillas using the traditional nixtamalization method of mayan communities. | 2003 | J. Nutr. | pmid:14519811 |
| Wang E et al. | Fumonisin B1 consumption by rats causes reversible, dose-dependent increases in urinary sphinganine and sphingosine. | 1999 | J. Nutr. | pmid:9915902 |
| Decker L and ffrench-Constant C | Lipid rafts and integrin activation regulate oligodendrocyte survival. | 2004 | J. Neurosci. | pmid:15084663 |
| Maysinger D et al. | Ceramide is responsible for the failure of compensatory nerve sprouting in apolipoprotein E knock-out mice. | 2008 | J. Neurosci. | pmid:18667621 |
| Hering H et al. | Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. | 2003 | J. Neurosci. | pmid:12716933 |
| Fortin DL et al. | Lipid rafts mediate the synaptic localization of alpha-synuclein. | 2004 | J. Neurosci. | pmid:15282274 |
| Furuya S et al. | Sphingolipid biosynthesis is necessary for dendrite growth and survival of cerebellar Purkinje cells in culture. | 1995 | J. Neurochem. | pmid:7561849 |
| Boldin S and Futerman AH | Glucosylceramide synthesis is required for basic fibroblast growth factor and laminin to stimulate axonal growth. | 1997 | J. Neurochem. | pmid:9003082 |
| Lovat PE et al. | Gangliosides link the acidic sphingomyelinase-mediated induction of ceramide to 12-lipoxygenase-dependent apoptosis of neuroblastoma in response to fenretinide. | 2004 | J. Natl. Cancer Inst. | pmid:15339967 |
| Musser SM et al. | Identification of an N-acetyl keto derivative of fumonisin B1 in corn cultures of Fusarium proliferatum. | 1995 | J. Nat. Prod. | pmid:7494146 |
| Van Overmeire I et al. | Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety. | 2000 | J. Med. Chem. | pmid:11063615 |
| Van Overmeire I et al. | Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons. | 1999 | J. Med. Chem. | pmid:10411490 |
| Wang G et al. | Regulation of primary cilia formation by ceramide. | 2009 | J. Lipid Res. | pmid:19372594 |
| Perry RJ and Ridgway ND | The role of de novo ceramide synthesis in the mechanism of action of the tricyclic xanthate D609. | 2004 | J. Lipid Res. | pmid:13130125 |
| Kavishwar A et al. | Unique sphingomyelin patches are targets of a beta-cell-specific antibody. | 2011 | J. Lipid Res. | pmid:21747097 |
| Tani M et al. | Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. | 2005 | J. Lipid Res. | pmid:16061940 |
| Lefrancois S et al. | Role of sphingolipids in the transport of prosaposin to the lysosomes. | 1999 | J. Lipid Res. | pmid:10484606 |
| Uchida Y et al. | De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes. | 2003 | J. Invest. Dermatol. | pmid:12648232 |
| Wakita H et al. | Inhibitors of sphingolipid synthesis modulate interferon (IFN)-gamma-induced intercellular adhesion molecule (ICAM)-1 and human leukocyte antigen (HLA)-DR expression on cultured normal human keratinocytes: possible involvement of ceramide in biologic action of IFN-gamma. | 1996 | J. Invest. Dermatol. | pmid:8751967 |
| Sharma RP et al. | Deletion of IFN-gamma reduces fumonisin-induced hepatotoxicity in mice via alterations in inflammatory cytokines and apoptotic factors. | 2003 | J. Interferon Cytokine Res. | pmid:12639295 |
| Pelled D et al. | The increased sensitivity of neurons with elevated glucocerebroside to neurotoxic agents can be reversed by imiglucerase. | 2000 | J. Inherit. Metab. Dis. | pmid:10801059 |
| Keller SE et al. | Factors affecting the growth of Fusarium proliferatum and the production of fumonisin B1: oxygen and pH. | 1997 | J. Ind. Microbiol. Biotechnol. | pmid:9439006 |
| Czeh A et al. | A flow cytometry based competitive fluorescent microsphere immunoassay (CFIA) system for detecting up to six mycotoxins. | 2012 | J. Immunol. Methods | pmid:22841575 |
| Kamps-Holtzapple C et al. | Analysis of hapten-carrier protein conjugates by nondenaturing gel electrophoresis. | 1993 | J. Immunol. Methods | pmid:8370930 |
| Goldfinger M et al. | De novo ceramide synthesis is required for N-linked glycosylation in plasma cells. | 2009 | J. Immunol. | pmid:19454701 |
| Gamen S et al. | Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways. | 1998 | J. Immunol. | pmid:9712041 |
| Kirkham PA et al. | Ligation of the WC1 receptor induces gamma delta T cell growth arrest through fumonisin B1-sensitive increases in cellular ceramide. | 2000 | J. Immunol. | pmid:11034356 |
| Litvak DA et al. | Modulators of ceramide metabolism sensitize colorectal cancer cells to chemotherapy: a novel treatment strategy. | 2003 | J. Gastrointest. Surg. | pmid:12559195 |
| Wang Y et al. | Development and application of a method for the analysis of 9 mycotoxins in maize by HPLC-MS/MS. | 2013 | J. Food Sci. | pmid:24245893 |
| Lo Magro S et al. | Assessment of fumonisins B1 and B2 levels in commercial maize-based food products by liquid chromatography with fluorimetric detection and postcolumn chemical derivatization. | 2011 Jan-Feb | J. Food Sci. | pmid:21535723 |
| Jackson LS et al. | Reduction of fumonisin Bâ‚ in corn grits by twin-screw extrusion. | 2011 | J. Food Sci. | pmid:22417527 |
| Harvey B et al. | Toxicity of fumonisin from Fusarium verticillioides culture material and moniliformin from Fusarium fujikuroi culture material when fed singly and in combination to growing barrows. | 2002 | J. Food Prot. | pmid:11848570 |
| Avantaggiato G et al. | Effects of muffin processing on fumonisins from 14C-labeled toxins produced in cultured corn kernels. | 2003 | J. Food Prot. | pmid:14572226 |
| Castoria R et al. | Occurrence of mycotoxin in Farro samples from southern Italy. | 2005 | J. Food Prot. | pmid:15726990 |
| Omurtag GZ and YazicioÄŸlu D | Determination of fumonisins B1 and B2 in herbal tea and medicinal plants in Turkey by high-performance liquid chromatography. | 2004 | J. Food Prot. | pmid:15330551 |
| Brera C et al. | Effect of industrial processing on the distribution of fumonisin B1 in dry milling corn fractions. | 2004 | J. Food Prot. | pmid:15222562 |
| De Girolamo A et al. | Effect of processing on fumonisin concentration in corn flakes. | 2001 | J. Food Prot. | pmid:11348004 |
| Seo E et al. | Fumonisins B1 and B2 in agricultural products consumed in South Korea: an exposure assessment. | 2009 | J. Food Prot. | pmid:19350995 |
| Voss KA et al. | Reduced toxicity of fumonisin B1 in corn grits by single-screw extrusion. | 2008 | J. Food Prot. | pmid:18939749 |
| Kushiro M et al. | Limited surveillance of fumonisins in brown rice and wheat harvested in Japan. | 2009 | J. Food Prot. | pmid:19610350 |
| Castellá G et al. | Fumonisin production by Fusarium species isolated from cereals and feeds in Spain. | 1999 | J. Food Prot. | pmid:10419279 |
| Chulze SN et al. | Fumonisin production on irradiated corn kernels: effect of inoculum size. | 1999 | J. Food Prot. | pmid:10419280 |
| Feng YZ et al. | Natural occurrence of fumonisins b1 and b2 in corn from three main production provinces in China. | 2011 | J. Food Prot. | pmid:21819670 |
| Ryu D et al. | Fumonisin B1 production by Fusarium moniliforme and Fusarium proliferatum as affected by cycling temperatures. | 1999 | J. Food Prot. | pmid:10606151 |
| Yates IE et al. | Trichoderma viride suppresses fumonisin B1 production by Fusarium moniliforme. | 1999 | J. Food Prot. | pmid:10571324 |
| Castelo MM et al. | Occurrence of fumonisins in corn-based food products. | 1998 | J. Food Prot. | pmid:9709253 |
| Castelo MM et al. | Stability of fumonisins in thermally processed corn products. | 1998 | J. Food Prot. | pmid:9713766 |
| Meredith FI et al. | Fumonisin B1 and hydrolyzed fumonisin B1 (AP1) in tortillas and nixtamalized corn (Zea mays L.) from two different geographic locations in Guatemala. | 1999 | J. Food Prot. | pmid:10528731 |
| Ariño A et al. | Natural occurrence of Fusarium species, fumonisin production by toxigenic strains, and concentrations of fumonisins B1, and B2 in conventional and organic maize grown in Spain. | 2007 | J. Food Prot. | pmid:17265874 |
| Gutema T et al. | Occurrence of fumonisins and moniliformin in corn and corn-based food products of U.S. origin. | 2000 | J. Food Prot. | pmid:11131899 |
| Magembe KS et al. | Mycotoxin Contamination in Stored Maize and Groundnuts Based on Storage Practices and Conditions in Subhumid Tropical Africa: The Case of Kilosa District, Tanzania. | 2016 | J. Food Prot. | pmid:28221960 |
| Shim WB et al. | Comparison of fumonisin B1 biosynthesis in maize germ and degermed kernels by Fusarium verticillioides. | 2003 | J. Food Prot. | pmid:14627291 |
| de Nijs M et al. | Assessment of human exposure to fumonisin B1. | 1998 | J. Food Prot. | pmid:9678173 |
| Martins ML et al. | Fumonisins B1 and B2 in black tea and medicinal plants. | 2001 | J. Food Prot. | pmid:11510675 |
| Omurtag GZ | Determination of fumonisin B1 and B2 in corn and corn-based products in Turkey by high-performance liquid chromatography. | 2001 | J. Food Prot. | pmid:11456195 |
| Tonnetti L et al. | A role for neutral sphingomyelinase-mediated ceramide production in T cell receptor-induced apoptosis and mitogen-activated protein kinase-mediated signal transduction. | 1999 | J. Exp. Med. | pmid:10330437 |
| Zhang X et al. | Hijacking of the jasmonate pathway by the mycotoxin fumonisin B1 (FB1) to initiate programmed cell death in Arabidopsis is modulated by RGLG3 and RGLG4. | 2015 | J. Exp. Bot. | pmid:25788731 |
| Palyusik M and Moran EM | Porcine pulmonary edema with hydrothorax: a review. | 1994 | J. Environ. Pathol. Toxicol. Oncol. | pmid:7823296 |
| Wang H et al. | The fumonisin B1 content in corn from North China, a high-risk area of esophageal cancer. | 2000 | J. Environ. Pathol. Toxicol. Oncol. | pmid:10905519 |
| Coulombe RA | Biological action of mycotoxins. | 1993 | J. Dairy Sci. | pmid:8463495 |
| Schmidt P et al. | Concentration of mycotoxins and chemical composition of corn silage: a farm survey using infrared thermography. | 2015 | J. Dairy Sci. | pmid:26162792 |
| Sharma RP et al. | Demonstration of in-situ apoptosis in mouse liver and kidney after short-term repeated exposure to fumonisin B1. | 1997 | J. Comp. Pathol. | pmid:9502273 |
| Suomalainen L et al. | Sphingosine-1-phosphate in inhibition of male germ cell apoptosis in the human testis. | 2003 | J. Clin. Endocrinol. Metab. | pmid:14602806 |
| Shetty PH and Bhat RV | Sensitive method for the detection of fumonisin B1 in human urine. | 1998 | J. Chromatogr. B Biomed. Sci. Appl. | pmid:9498687 |
| Tardieu D et al. | Determination of Fumonisin B1 in animal tissues with immunoaffinity purification. | 2008 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:18571484 |
| Li L et al. | Development of immune-affinity 96 spots monolith array for multiple mycotoxins detection in food samples. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:27423670 |
| Pagliuca G et al. | Simple method for the simultaneous isolation and determination of fumonisin B1 and its metabolite aminopentol-1 in swine liver by liquid chromatography--fluorescence detection. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:15797527 |
| Shephard GS et al. | Determination of fumonisin B1 in plasma and urine by high-performance liquid chromatography. | 1992 | J. Chromatogr. | pmid:1618963 |
| Sauane M et al. | Ceramide plays a prominent role in MDA-7/IL-24-induced cancer-specific apoptosis. | 2010 | J. Cell. Physiol. | pmid:19937735 |
| Le Stunff H et al. | Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. | 2002 | J. Cell Biol. | pmid:12235122 |
| Mays RW et al. | Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells. | 1995 | J. Cell Biol. | pmid:7657695 |
| Heinl S et al. | Degradation of fumonisin B1 by the consecutive action of two bacterial enzymes. | 2010 | J. Biotechnol. | pmid:19922747 |
| El Bawab S et al. | Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. | 2001 | J. Biol. Chem. | pmid:11278489 |
| Kuroyanagi M et al. | Vacuolar processing enzyme is essential for mycotoxin-induced cell death in Arabidopsis thaliana. | 2005 | J. Biol. Chem. | pmid:16043487 |
| Chalfant CE et al. | De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. | 2002 | J. Biol. Chem. | pmid:11801602 |
| Le Stunff H et al. | Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. | 2004 | J. Biol. Chem. | pmid:15180992 |
| Kroesen BJ et al. | Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. | 2001 | J. Biol. Chem. | pmid:11278517 |
| Stevens VL and Tang J | Fumonisin B1-induced sphingolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinositol-anchored folate receptor. | 1997 | J. Biol. Chem. | pmid:9218430 |
| Jenkins GM et al. | Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins. | 2002 | J. Biol. Chem. | pmid:12200446 |
| Wang E et al. | Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. | 1991 | J. Biol. Chem. | pmid:1860857 |
| Zitomer NC et al. | Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals. | 2009 | J. Biol. Chem. | pmid:19095642 |
| Hinkovska-Galcheva V et al. | Enhanced phagocytosis through inhibition of de novo ceramide synthesis. | 2003 | J. Biol. Chem. | pmid:12424251 |
| Wieder T et al. | Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine. | 1998 | J. Biol. Chem. | pmid:9556584 |
| Sofer A and Futerman AH | Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP. | 1995 | J. Biol. Chem. | pmid:7744860 |
| Jarvis WD et al. | Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. | 1996 | J. Biol. Chem. | pmid:8626522 |
| Penno A et al. | Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids. | 2010 | J. Biol. Chem. | pmid:20097765 |
| Riebeling C et al. | Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. | 2003 | J. Biol. Chem. | pmid:12912983 |
| Zhang Y et al. | The mycotoxin fumonisin B1 transcriptionally activates the p21 promoter through a cis-acting element containing two Sp1 binding sites. | 1999 | J. Biol. Chem. | pmid:10212208 |
| Kitatani K et al. | Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. | 2007 | J. Biol. Chem. | pmid:17504762 |
| Williamson LC et al. | Neuronal sensitivity to tetanus toxin requires gangliosides. | 1999 | J. Biol. Chem. | pmid:10455200 |
| Becker KP et al. | Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. | 2005 | J. Biol. Chem. | pmid:15546881 |
| Cuvillier O et al. | Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. | 2000 | J. Biol. Chem. | pmid:10747891 |
| Mao C et al. | Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. | 2000 | J. Biol. Chem. | pmid:10702247 |
| Hernández-Corbacho MJ et al. | Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. | 2015 | J. Biol. Chem. | pmid:26318452 |