fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.
To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with fumonisin b1
Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Monnet-Tschudi F et al. | The naturally occurring food mycotoxin fumonisin B1 impairs myelin formation in aggregating brain cell culture. | 1999 | Neurotoxicology | pmid:10091857 |
Saucedo-GarcÃa M et al. | MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. | 2011 | New Phytol. | pmid:21534970 |
Wolf G | Inhibition of cellular uptake of folate by blocking synthesis of the membrane folate receptor. | 1998 | Nutr. Rev. | pmid:9564182 |
Wolf G | Mechanism of the mitogenic and carcinogenic action of fumonisin B1, a mycotoxin. | 1994 | Nutr. Rev. | pmid:8090377 |
White-Gilbertson S et al. | Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. | 2009 | Oncogene | pmid:19137010 |
Kellerman TS et al. | Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. | 1990 | Onderstepoort J. Vet. Res. | pmid:2293136 |
Marasas WF et al. | Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. | 1988 | Onderstepoort J. Vet. Res. | pmid:3217091 |
Hwang D et al. | Effects of ceramide inhibition on experimental radiation-induced oral mucositis. | 2005 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod | pmid:16122660 |
Nogueira TC et al. | Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion. | 2008 | Pancreas | pmid:18815554 |
Mazzoni E et al. | Field control of Fusarium ear rot, Ostrinia nubilalis (Hübner), and fumonisins in maize kernels. | 2011 | Pest Manag. Sci. | pmid:21394878 |
Demirel G et al. | Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells. | 2015 | Pharm Biol | pmid:25858139 |
Eichele K et al. | R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. | 2009 | Pharm. Res. | pmid:19015962 |
Atroshi F et al. | Fumonisin B1-induced DNA damage in rat liver and spleen: effects of pretreatment with coenzyme Q10, L-carnitine, alpha-tocopherol and selenium. | 1999 | Pharmacol. Res. | pmid:10660942 |
Atroshi F et al. | Effects of tamoxifen, melatonin, coenzyme Q10, and L-carnitine supplementation on bacterial growth in the presence of mycotoxins. | 1998 | Pharmacol. Res. | pmid:9774492 |
Dutton MF | Fumonisins, mycotoxins of increasing importance: their nature and their effects. | 1996 | Pharmacol. Ther. | pmid:8843466 |
He Q et al. | Pharmacological antagonism of fumonisin B1 cytotoxicity in porcine renal epithelial cells (LLC-PK1): a model for reducing fumonisin-induced nephrotoxicity in vivo. | 2002 | Pharmacol. Toxicol. | pmid:12076308 |
Boppana NB et al. | Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization. | 2014 | Photochem. Photobiol. Sci. | pmid:25266739 |
Szabó A et al. | Oral administration of fumonisin B and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits. | 2016 | Physiol Int | pmid:28229635 |
Arias SL et al. | Toxin distribution and sphingoid base imbalances in Fusarium verticillioides-infected and fumonisin B1-watered maize seedlings. | 2016 | Phytochemistry | pmid:26903312 |
Abbas HK et al. | Biological activities of synthetic analogues of Alternaria alternata toxin (AAL-toxin) and fumonisin in plant and mammalian cell cultures. | 1995 | Phytochemistry | pmid:8590636 |
Desjardins AE et al. | Identification and heritability of fumonisin insensitivity in Zea mays. | 2005 | Phytochemistry | pmid:16198380 |
Markham JE et al. | Sphingolipids containing very-long-chain fatty acids define a secretory pathway for specific polar plasma membrane protein targeting in Arabidopsis. | 2011 | Plant Cell | pmid:21666002 |
Chivasa S et al. | Extracellular ATP functions as an endogenous external metabolite regulating plant cell viability. | 2005 | Plant Cell | pmid:16199612 |
Asai T et al. | Fumonisin B1-induced cell death in arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways. | 2000 | Plant Cell | pmid:11041879 |
Kimberlin AN et al. | Arabidopsis 56-amino acid serine palmitoyltransferase-interacting proteins stimulate sphingolipid synthesis, are essential, and affect mycotoxin sensitivity. | 2013 | Plant Cell | pmid:24214397 |
Stone JM et al. | Simulation of fungal-mediated cell death by fumonisin B1 and selection of fumonisin B1-resistant (fbr) Arabidopsis mutants. | 2000 | Plant Cell | pmid:11041878 |
Basnayake BM et al. | Arabidopsis DAL1 and DAL2, two RING finger proteins homologous to Drosophila DIAP1, are involved in regulation of programmed cell death. | 2011 | Plant Cell Rep. | pmid:20972793 |
Zhao Y et al. | Classic myrosinase-dependent degradation of indole glucosinolate attenuates fumonisin B1-induced programmed cell death in Arabidopsis. | 2015 | Plant J. | pmid:25645692 |
Stone JM et al. | Arabidopsis AtSPL14, a plant-specific SBP-domain transcription factor, participates in plant development and sensitivity to fumonisin B1. | 2005 | Plant J. | pmid:15703061 |
Bindschedler LV et al. | Peroxidase-dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance. | 2006 | Plant J. | pmid:16889645 |
Watanabe N and Lam E | Arabidopsis Bax inhibitor-1 functions as an attenuator of biotic and abiotic types of cell death. | 2006 | Plant J. | pmid:16507080 |
Aubert A et al. | Sphingolipids involvement in plant endomembrane differentiation: the BY2 case. | 2011 | Plant J. | pmid:21205030 |
Lin SS et al. | RING1 E3 ligase localizes to plasma membrane lipid rafts to trigger FB1-induced programmed cell death in Arabidopsis. | 2008 | Plant J. | pmid:18643987 |
Lenz HD et al. | Autophagy differentially controls plant basal immunity to biotrophic and necrotrophic pathogens. | 2011 | Plant J. | pmid:21332848 |
Luttgeharm KD et al. | Overexpression of Arabidopsis Ceramide Synthases Differentially Affects Growth, Sphingolipid Metabolism, Programmed Cell Death, and Mycotoxin Resistance. | 2015 | Plant Physiol. | pmid:26276842 |
Feng H et al. | Functional characterization of the Arabidopsis eukaryotic translation initiation factor 5A-2 that plays a crucial role in plant growth and development by regulating cell division, cell growth, and cell death. | 2007 | Plant Physiol. | pmid:17513484 |
Qin X et al. | Sphingosine kinase AtSPHK1 functions in fumonisin B1-triggered cell death in Arabidopsis. | 2017 | Plant Physiol. Biochem. | pmid:28846870 |
Lenz HD et al. | ATG7 contributes to plant basal immunity towards fungal infection. | 2011 | Plant Signal Behav | pmid:21617379 |
Saucedo-GarcÃa M et al. | Reactive oxygen species as transducers of sphinganine-mediated cell death pathway. | 2011 | Plant Signal Behav | pmid:21921699 |
Gutiérrez-Nájera N et al. | Fumonisin B1, a sphingoid toxin, is a potent inhibitor of the plasma membrane H+-ATPase. | 2005 | Planta | pmid:15703925 |
Sánchez-Rangel D et al. | Fumonisin B1, a toxin produced by Fusarium verticillioides, modulates maize β-1,3-glucanase activities involved in defense response. | 2012 | Planta | pmid:22120123 |
De Jong AJ et al. | Chemical-induced apoptotic cell death in tomato cells: involvement of caspase-like proteases. | 2000 | Planta | pmid:11089678 |
Shin KO et al. | Terpene alcohols inhibit de novo sphingolipid biosynthesis. | 2012 | Planta Med. | pmid:22274813 |
Liao YJ et al. | Inhibition of fumonisin B1 cytotoxicity by nanosilicate platelets during mouse embryo development. | 2014 | PLoS ONE | pmid:25383881 |
He S et al. | The LSD1-interacting protein GILP is a LITAF domain protein that negatively regulates hypersensitive cell death in Arabidopsis. | 2011 | PLoS ONE | pmid:21526181 |
Kacprzyk J et al. | The root hair assay facilitates the use of genetic and pharmacological tools in order to dissect multiple signalling pathways that lead to programmed cell death. | 2014 | PLoS ONE | pmid:24755572 |
Lee H et al. | Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. | 2011 | PLoS ONE | pmid:21695182 |
Malapi-Wight M et al. | Sda1, a Cys2-His2 zinc finger transcription factor, is involved in polyol metabolism and fumonisin B1 production in Fusarium verticillioides. | 2013 | PLoS ONE | pmid:23844049 |
Czembor E et al. | Effect of Environmental Factors on Fusarium Species and Associated Mycotoxins in Maize Grain Grown in Poland. | 2015 | PLoS ONE | pmid:26225823 |
Agostini F et al. | Prion protein accumulation in lipid rafts of mouse aging brain. | 2013 | PLoS ONE | pmid:24040215 |
Igarashi D et al. | Pattern-triggered immunity suppresses programmed cell death triggered by fumonisin b1. | 2013 | PLoS ONE | pmid:23560104 |
Broomhead JN et al. | Chronic effects of fumonisin B1 in broilers and turkeys fed dietary treatments to market age. | 2002 | Poult. Sci. | pmid:11885900 |
Vesonder RF and Wu W | Correlation of moniliformin, but not fumonisin B1 levels, in culture materials of Fusarium isolates to acute death in ducklings. | 1998 | Poult. Sci. | pmid:9469753 |
Henry MH and Wyatt RD | The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. | 2001 | Poult. Sci. | pmid:11297276 |
Siloto EV et al. | Lipid metabolism of commercial layers fed diets containing aflatoxin, fumonisin, and a binder. | 2013 | Poult. Sci. | pmid:23873555 |
Rossi F et al. | Effect of Bt corn on broiler growth performance and fate of feed-derived DNA in the digestive tract. | 2005 | Poult. Sci. | pmid:16050119 |
Weibking TS et al. | Individual and combined effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, and aflatoxin B1 in the young turkey poult. | 1994 | Poult. Sci. | pmid:7816726 |
Miazzo R et al. | Efficacy of sodium bentonite as a detoxifier of broiler feed contaminated with aflatoxin and fumonisin. | 2005 | Poult. Sci. | pmid:15685935 |
Henry MH et al. | The toxicity of purified fumonisin B1 in broiler chicks. | 2000 | Poult. Sci. | pmid:11055840 |
Ledoux DR et al. | Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, in the young turkey poult. | 1996 | Poult. Sci. | pmid:9000269 |
Keck BB and Bodine AB | The effects of fumonisin B1 on viability and mitogenic response of avian immune cells. | 2006 | Poult. Sci. | pmid:16776470 |
Asrani RK et al. | Effects of feeding Fusarium verticillioides (formerly Fusarium moniliforme) culture material containing known levels of fumonisin B1 in Japanese quail (Coturnix coturnix japonica). | 2006 | Poult. Sci. | pmid:16830851 |
Del Bianchi M et al. | Effects of prolonged oral administration of aflatoxin B1 and fumonisin B1 in broiler chickens. | 2005 | Poult. Sci. | pmid:16479938 |
Tardieu D et al. | Toxicity of maize containing known levels of fumonisin B1 during force-feeding of ducks. | 2004 | Poult. Sci. | pmid:15339002 |
Qureshi MA and Hagler WM | Effect of fumonisin-B1 exposure on chicken macrophage functions in vitro. | 1992 | Poult. Sci. | pmid:1539010 |
Kubena LF et al. | Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and diacetoxyscirpenol or ochratoxin A in turkey poults. | 1997 | Poult. Sci. | pmid:9057204 |
Sharma D et al. | Individual and combined effects of fumonisin b1 and moniliformin on clinicopathological and cell-mediated immune response in Japanese quail. | 2008 | Poult. Sci. | pmid:18492990 |
Kubena LF et al. | Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and T-2 toxin or deoxynivalenol in broiler chicks. | 1997 | Poult. Sci. | pmid:9276886 |
Kubena LF et al. | Effects of long-term feeding of diets containing moniliformin, supplied by Fusarium fujikuroi culture material, and fumonisin, supplied by Fusarium moniliforme culture material, to laying hens. | 1999 | Poult. Sci. | pmid:10560820 |
Kubena LF et al. | Influence of fumonisin B1, present in Fusarium moniliforme culture material, and T-2 toxin on turkey poults. | 1995 | Poult. Sci. | pmid:7724453 |
Li YC et al. | Effects of fumonisin B1 on selected immune responses in broiler chicks. | 1999 | Poult. Sci. | pmid:10515357 |
Tran ST et al. | Chronic effects of fumonisin B1 on ducks. | 2005 | Poult. Sci. | pmid:15685938 |
Li YC et al. | The individual and combined effects of fumonisin B1 and moniliformin on performance and selected immune parameters in turkey poults. | 2000 | Poult. Sci. | pmid:10875770 |
Weibking TS et al. | Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, on the young broiler chick. | 1993 | Poult. Sci. | pmid:8464788 |
Ogido R et al. | Effects of prolonged administration of aflatoxin B1 and fumonisin B1 in laying Japanese quail. | 2004 | Poult. Sci. | pmid:15615006 |
Rauber RH et al. | Individual and combined effects of Salmonella typhimurium lipopolysaccharide and fumonisin B1 in broiler chickens. | 2012 | Poult. Sci. | pmid:23091133 |
Kubena LF et al. | Effects of feeding fumonisin B1 present in Fusarium moniliforme culture material and aflatoxin singly and in combination to turkey poults. | 1995 | Poult. Sci. | pmid:7479507 |
Wu W et al. | The effect of fumonisin B1 on isolated chondrocytes and on bone formation. | 1995 | Poult. Sci. | pmid:7501587 |
Khalil AA et al. | Protective role of probiotic lactic acid bacteria against dietary fumonisin B1-induced toxicity and DNA-fragmentation in sprague-dawley rats. | 2015 | Prep. Biochem. Biotechnol. | pmid:25036875 |
Kononenko GP et al. | [Application of competitive immunoenzyme assay for analysis of group B fumonisins]. | 1999 Mar-Apr | Prikl. Biokhim. Mikrobiol. | pmid:10368851 |
Brandwagt BF et al. | A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10781105 |
Wang W et al. | Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells. | 1996 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8622958 |
De Nadai C et al. | Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10792026 |
Porter JK et al. | Effects of Fusarium moniliforme and corn associated with equine leukoencephalomalacia on rat neurotransmitters and metabolites. | 1990 | Proc. Soc. Exp. Biol. Med. | pmid:1972578 |
Porter JK et al. | Neurotransmitters in rats fed fumonisin B1. | 1993 | Proc. Soc. Exp. Biol. Med. | pmid:7679795 |
Soriano JM et al. | Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1. | 2005 | Prog. Lipid Res. | pmid:16266752 |
Gelderblom WC et al. | Regulation of fatty acid biosynthesis as a possible mechanism for the mitoinhibitory effect of fumonisin B1 in primary rat hepatocytes. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10574646 |
Seegers JC et al. | Fumonisin B1 influenced the effects of arachidonic acid, prostaglandins E2 and A2 on cell cycle progression, apoptosis induction, tyrosine- and CDC2-kinase activity in oesophageal cancer cells. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10780872 |
Hines HB et al. | Fumonisin B1 analysis with capillary electrophoresis-electrospray ionization mass spectrometry. | 1995 | Rapid Commun. Mass Spectrom. | pmid:7606046 |
Paepens C et al. | Development of a liquid chromatography/tandem mass spectrometry method for the quantification of fumonisin B1, B2 and B3 in cornflakes. | 2005 | Rapid Commun. Mass Spectrom. | pmid:15973649 |
Korfmacher WA et al. | Characterization of the mycotoxin fumonisin B1: comparison of thermospray, fast-atom bombardment and electrospray mass spectrometry. | 1991 | Rapid Commun. Mass Spectrom. | pmid:1841646 |
Bartók T et al. | Detection and characterization of twenty-eight isomers of fumonisin B1 (FB1) mycotoxin in a solid rice culture infected with Fusarium verticillioides by reversed-phase high-performance liquid chromatography/electrospray ionization time-of-flight and ion trap mass spectrometry. | 2010 | Rapid Commun. Mass Spectrom. | pmid:19960490 |
Josephs JL | Detection and characterization of fumonisin mycotoxins by liquid chromatography/electrospray ionization using ion trap and triple quadrupole mass spectrometry. | 1996 | Rapid Commun. Mass Spectrom. | pmid:8805843 |
Kalo D and Roth Z | Involvement of the sphingolipid ceramide in heat-shock-induced apoptosis of bovine oocytes. | 2011 | Reprod. Fertil. Dev. | pmid:21871207 |
Ewuola EO and Egbunike GN | Effects of dietary fumonisin B1 on the onset of puberty, semen quality, fertility rates and testicular morphology in male rabbits. | 2010 | Reproduction | pmid:19917669 |
Cavaglieri L et al. | Screening procedures for selecting rhizobacteria with biocontrol effects upon Fusarium verticillioides growth and fumonisin B1 production. | 2004 | Res. Microbiol. | pmid:15501652 |
Cavaglieri L et al. | Biocontrol of Bacillus subtilis against Fusarium verticillioides in vitro and at the maize root level. | 2005 Jun-Jul | Res. Microbiol. | pmid:15950130 |
Kovács M et al. | Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocida. | 2016 | Res. Vet. Sci. | pmid:27663368 |
Martins HM et al. | Occurrence of fumonisins in feed for swine and horses. | 2012 Jul-Sep | Rev Iberoam Micol | pmid:21907302 |
del RÃo GarcÃa JC et al. | [Evaluation of the cytotoxicity of aflatoxin and fumonisin in swine intestinal cells]. | 2007 | Rev Iberoam Micol | pmid:17604433 |