fumonisin b1
fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.
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Introduction
To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with fumonisin b1?
fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with fumonisin b1
PubChem Associated disorders and diseases
What pathways are associated with fumonisin b1
Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with fumonisin b1?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with fumonisin b1?
Related references are published most in these journals:
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What lipids are associated with fumonisin b1?
Related references are published most in these journals:
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What genes are associated with fumonisin b1?
Related references are published most in these journals:
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What common seen animal models are associated with fumonisin b1?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with fumonisin b1
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ferrante MC et al. | Effect of fumonisin B1 on structure and function of macrophage plasma membrane. | 2002 | Toxicol. Lett. | pmid:11888701 |
| Bondy GS et al. | Retrospective evaluation of serum ornithine carbamyltransferase activity as an index of hepatotoxicity in toxicological studies with rats. | 2000 | Toxicol. Lett. | pmid:10713481 |
| Raynal M et al. | Effects of fumonisin B1 present in Fusarium moniliforme culture material on drug metabolising enzyme activities in ducks. | 2001 | Toxicol. Lett. | pmid:11369472 |
| Wan LY et al. | Individual and combined effects of Fusarium toxins on the mRNA expression of pro-inflammatory cytokines in swine jejunal epithelial cells. | 2013 | Toxicol. Lett. | pmid:23688591 |
| Clarke R et al. | High content analysis: a sensitive tool to detect and quantify the cytotoxic, synergistic and antagonistic effects of chemical contaminants in foods. | 2015 | Toxicol. Lett. | pmid:25623391 |
| Chuturgoon AA et al. | Fumonisin Bâ‚ modulates expression of human cytochrome P450 1b1 in human hepatoma (Hepg2) cells by repressing Mir-27b. | 2014 | Toxicol. Lett. | pmid:24614526 |
| Bouhet S et al. | The mycotoxin fumonisin B1 alters the proliferation and the barrier function of porcine intestinal epithelial cells. | 2004 | Toxicol. Sci. | pmid:14600282 |
| Taranu I et al. | Mycotoxin fumonisin B1 alters the cytokine profile and decreases the vaccinal antibody titer in pigs. | 2005 | Toxicol. Sci. | pmid:15659571 |
| Dragan YP et al. | Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example. | 2001 | Toxicol. Sci. | pmid:11294969 |
| He Q et al. | Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases. | 2004 | Toxicol. Sci. | pmid:15103051 |
| He Q et al. | Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver. | 2006 | Toxicol. Sci. | pmid:16960033 |
| Enongene EN et al. | Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase. | 2002 | Toxicol. Sci. | pmid:12011476 |
| Voss KA et al. | Reproductive and sphingolipid metabolic effects of fumonisin B(1) and its alkaline hydrolysis product in LM/Bc mice: hydrolyzed fumonisin B(1) did not cause neural tube defects. | 2009 | Toxicol. Sci. | pmid:19783636 |
| Voss KA et al. | Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha. | 2006 | Toxicol. Sci. | pmid:16221962 |
| Wan LY et al. | Modulation of mucin mRNA (MUC5AC and MUC5B) expression and protein production and secretion in Caco-2/HT29-MTX co-cultures following exposure to individual and combined Fusarium mycotoxins. | 2014 | Toxicol. Sci. | pmid:24496642 |
| Mathur S et al. | Fumonisin B(1) increases serum sphinganine concentration but does not alter serum sphingosine concentration or induce cardiovascular changes in milk-fed calves. | 2001 | Toxicol. Sci. | pmid:11248151 |
| Mathur S et al. | Fumonisin B(1) is hepatotoxic and nephrotoxic in milk-fed calves. | 2001 | Toxicol. Sci. | pmid:11248152 |
| Gelderblom WC et al. | Interaction of fumonisin B(1) and aflatoxin B(1) in a short-term carcinogenesis model in rat liver. | 2002 | Toxicology | pmid:11836022 |
| Bhandari N and Sharma RP | Fumonisin B(1)-induced alterations in cytokine expression and apoptosis signaling genes in mouse liver and kidney after an acute exposure. | 2002 | Toxicology | pmid:11882348 |
| Bailly JD et al. | Toxicity of Fusarium moniliforme culture material containing known levels of fumonisin B1 in ducks. | 2001 | Toxicology | pmid:11376861 |
| Sharma N et al. | Augmented fumonisin B1 toxicity in co-cultures: evidence for crosstalk between macrophages and non-parenchymatous liver epithelial cells involving proinflammatory cytokines. | 2004 | Toxicology | pmid:15363598 |
| Stockmann-Juvala H et al. | Fumonisin B1-induced toxicity and oxidative damage in U-118MG glioblastoma cells. | 2004 | Toxicology | pmid:15337581 |
| Creppy EE et al. | Synergistic effects of fumonisin B1 and ochratoxin A: are in vitro cytotoxicity data predictive of in vivo acute toxicity? | 2004 | Toxicology | pmid:15297026 |
| Gelderblom WC et al. | Toxicological effects in rats chronically fed low dietary levels of fumonisin B(1). | 2001 | Toxicology | pmid:11295254 |
| Stockmann-Juvala H et al. | Fumonisin B1-induced apoptosis in neuroblastoma, glioblastoma and hypothalamic cell lines. | 2006 | Toxicology | pmid:16860453 |
| Domijan AM et al. | Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B(1)-treated rats. | 2006 | Toxicology | pmid:16497426 |
| Theumer MG et al. | Subchronic mycotoxicoses in Wistar rats: assessment of the in vivo and in vitro genotoxicity induced by fumonisins and aflatoxin B(1), and oxidative stress biomarkers status. | 2010 | Toxicology | pmid:20015463 |
| Lock EA et al. | Caspase-dependent and -independent induction of phosphatidylserine externalization during apoptosis in human renal carcinoma Cak(1)-1 and A-498 cells. | 2007 | Toxicology | pmid:17097791 |
| Sharma N et al. | Amelioration of fumonisin B1 hepatotoxicity in mice by depletion of T cells with anti-Thy-1.2. | 2006 | Toxicology | pmid:16690192 |
| van der Westhuizen L et al. | Disruption of sphingolipid biosynthesis in hepatocyte nodules: selective proliferative stimulus induced by fumonisin B1. | 2004 | Toxicology | pmid:15158565 |
| Gelderblom WC et al. | Cancer initiating properties of fumonisin B1 in a short-term rat liver carcinogenesis assay. | 2008 | Toxicology | pmid:18616970 |
| Gopee NV and Sharma RP | Sphingoid bases and their phosphates: transient activation and delayed repression of protein kinase C isoforms and their possible involvement in fumonisin B1 cytotoxicity. | 2003 | Toxicology | pmid:12699912 |
| Mobio TA et al. | Comparative study of the toxic effects of fumonisin B1 in rat C6 glioma cells and p53-null mouse embryo fibroblasts. | 2003 | Toxicology | pmid:12504343 |
| Theumer MG et al. | Immunobiological effects of AFB1 and AFB1-FB1 mixture in experimental subchronic mycotoxicoses in rats. | 2003 | Toxicology | pmid:12604180 |
| Domijan AM et al. | Fumonisin B(1): oxidative status and DNA damage in rats. | 2007 | Toxicology | pmid:17291664 |
| Rumora L et al. | Mycotoxin fumonisin B1 alters cellular redox balance and signalling pathways in rat liver and kidney. | 2007 | Toxicology | pmid:17949882 |
| Kouadio JH et al. | Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. | 2005 | Toxicology | pmid:16019124 |
| Sharma RP et al. | Tolerance to fumonisin toxicity in a mouse strain lacking the P75 tumor necrosis factor receptor. | 2000 | Toxicology | pmid:10755704 |
| Biswal SS et al. | Changes in ceramide and sphingomyelin following fludarabine treatment of human chronic B-cell leukemia cells. | 2000 | Toxicology | pmid:11118669 |
| Chuturgoon A et al. | Fumonisin B1 induces global DNA hypomethylation in HepG2 cells - An alternative mechanism of action. | 2014 | Toxicology | pmid:24280379 |
| Suzuki H et al. | Inducible nitric oxide has protective effect on fumonisin B1 hepatotoxicity in mice via modulation of sphingosine kinase. | 2007 | Toxicology | pmid:17095132 |
| Voss KA et al. | The role of tumor necrosis factor alpha and the peroxisome proliferator-activated receptor alpha in modulating the effects of fumonisin in mouse liver. | 2006 | Toxicology | pmid:16574297 |
| Sharma RP et al. | Lupus-prone NZBWF1/J mice, defective in cytokine signaling, are resistant to fumonisin hepatotoxicity despite accumulation of liver sphinganine. | 2005 | Toxicology | pmid:16159691 |
| Abel S and Gelderblom WC | Oxidative damage and fumonisin B1-induced toxicity in primary rat hepatocytes and rat liver in vivo. | 1998 | Toxicology | pmid:9928627 |
| Romero A et al. | Mycotoxins modify the barrier function of Caco-2 cells through differential gene expression of specific claudin isoforms: Protective effect of illite mineral clay. | 2016 | Toxicology | pmid:27153755 |
| He Q et al. | Fumonisin B1 hepatotoxicity in mice is attenuated by depletion of Kupffer cells by gadolinium chloride. | 2005 | Toxicology | pmid:15590129 |
| Gumprecht LA et al. | Species and organ specificity of fumonisin-induced endothelial alterations: potential role in porcine pulmonary edema. | 2001 | Toxicology | pmid:11246126 |
| Sharma RP et al. | Decreased fumonisin hepatotoxicity in mice with a targeted deletion of tumor necrosis factor receptor 1. | 2001 | Toxicology | pmid:11250056 |
| Bhandari N et al. | Gender-related differences in subacute fumonisin B1 hepatotoxicity in BALB/c mice. | 2001 | Toxicology | pmid:11522378 |
| Mary VS et al. | Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells. | 2012 | Toxicology | pmid:22981896 |