fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.
To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with fumonisin b1
Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Yi F et al. | Mechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: role of guanine nucleotide exchange factor Vav2. | 2007 | Cell. Physiol. Biochem. | pmid:17982273 |
Schilling T and Eder C | Importance of lipid rafts for lysophosphatidylcholine-induced caspase-1 activation and reactive oxygen species generation. | 2010 | Cell. Immunol. | pmid:20832779 |
Shi L et al. | Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. | 2007 | Cell Res. | pmid:18059378 |
Aflaki E et al. | C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. | 2012 | Cell Death Dis | pmid:22419109 |
Lang KS et al. | Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. | 2004 | Cell Death Differ. | pmid:14615798 |
Appierto V et al. | Involvement of c-Fos in fenretinide-induced apoptosis in human ovarian carcinoma cells. | 2004 | Cell Death Differ. | pmid:14647238 |
Miguet C et al. | Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. | 2001 | Cell Death Differ. | pmid:11313706 |
Ciarlo L et al. | Association of fission proteins with mitochondrial raft-like domains. | 2010 | Cell Death Differ. | pmid:20075943 |
Gamen S et al. | Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. | 1998 | Cell Death Differ. | pmid:10200470 |
Spinedi A et al. | Ceramide accumulation precedes caspase-dependent apoptosis in CHP-100 neuroepithelioma cells exposed to the protein phosphatase inhibitor okadaic acid. | 1999 | Cell Death Differ. | pmid:10453072 |
Gopee NV and Sharma RP | The mycotoxin fumonisin B1 transiently activates nuclear factor-kappaB, tumor necrosis factor alpha and caspase 3 via protein kinase Calpha-dependent pathway in porcine renal epithelial cells. | 2004 | Cell Biol. Toxicol. | pmid:15499968 |
Gelderblom WC et al. | Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. | 1991 | Carcinogenesis | pmid:1649015 |
Gelderblom WC et al. | The cancer-initiating potential of the fumonisin B mycotoxins. | 1992 | Carcinogenesis | pmid:1547534 |
Lemmer ER et al. | Fumonisin B1-induced hepatocellular and cholangiocellular tumors in male Fischer 344 rats: potentiating effects of 2-acetylaminofluorene on oval cell proliferation and neoplastic development in a discontinued feeding study. | 2004 | Carcinogenesis | pmid:14988222 |
Lemmer ER et al. | Histopathology and gene expression changes in rat liver during feeding of fumonisin B1, a carcinogenic mycotoxin produced by Fusarium moniliforme. | 1999 | Carcinogenesis | pmid:10334199 |
Gelderblom WC et al. | Fumonisin B1 dosimetry in relation to cancer initiation in rat liver. | 1994 | Carcinogenesis | pmid:8313510 |
Pinelli E et al. | Activation of mitogen-activated protein kinase by fumonisin B(1) stimulates cPLA(2) phosphorylation, the arachidonic acid cascade and cAMP production. | 1999 | Carcinogenesis | pmid:10469611 |
Tolleson WH et al. | Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells. | 1996 | Carcinogenesis | pmid:8625445 |
Abdel Nour AM et al. | Folate receptor and human reduced folate carrier expression in HepG2 cell line exposed to fumonisin B1 and folate deficiency. | 2007 | Carcinogenesis | pmid:17615259 |
Ramljak D et al. | A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity. | 2000 | Carcinogenesis | pmid:10910956 |