fumonisin b1

fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.

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Introduction

To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with fumonisin b1?

fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with fumonisin b1

PubChem Associated disorders and diseases

What pathways are associated with fumonisin b1

Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with fumonisin b1?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with fumonisin b1?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with fumonisin b1?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with fumonisin b1?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with fumonisin b1?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with fumonisin b1

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Authors Title Published Journal PubMed Link
He Q et al. Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases. 2004 Toxicol. Sci. pmid:15103051
He Q et al. Ceramide synthase inhibition by fumonisin B1 treatment activates sphingolipid-metabolizing systems in mouse liver. 2006 Toxicol. Sci. pmid:16960033
Enongene EN et al. Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase. 2002 Toxicol. Sci. pmid:12011476
Voss KA et al. Reproductive and sphingolipid metabolic effects of fumonisin B(1) and its alkaline hydrolysis product in LM/Bc mice: hydrolyzed fumonisin B(1) did not cause neural tube defects. 2009 Toxicol. Sci. pmid:19783636
Voss KA et al. Toxic effects of fumonisin in mouse liver are independent of the peroxisome proliferator-activated receptor alpha. 2006 Toxicol. Sci. pmid:16221962
Mathur S et al. Fumonisin B(1) increases serum sphinganine concentration but does not alter serum sphingosine concentration or induce cardiovascular changes in milk-fed calves. 2001 Toxicol. Sci. pmid:11248151
Mathur S et al. Fumonisin B(1) is hepatotoxic and nephrotoxic in milk-fed calves. 2001 Toxicol. Sci. pmid:11248152
Gelderblom WC et al. Interaction of fumonisin B(1) and aflatoxin B(1) in a short-term carcinogenesis model in rat liver. 2002 Toxicology pmid:11836022
Bailly JD et al. Toxicity of Fusarium moniliforme culture material containing known levels of fumonisin B1 in ducks. 2001 Toxicology pmid:11376861
Sharma N et al. Augmented fumonisin B1 toxicity in co-cultures: evidence for crosstalk between macrophages and non-parenchymatous liver epithelial cells involving proinflammatory cytokines. 2004 Toxicology pmid:15363598
Stockmann-Juvala H et al. Fumonisin B1-induced toxicity and oxidative damage in U-118MG glioblastoma cells. 2004 Toxicology pmid:15337581
Creppy EE et al. Synergistic effects of fumonisin B1 and ochratoxin A: are in vitro cytotoxicity data predictive of in vivo acute toxicity? 2004 Toxicology pmid:15297026
Gelderblom WC et al. Toxicological effects in rats chronically fed low dietary levels of fumonisin B(1). 2001 Toxicology pmid:11295254
Theumer MG et al. Subchronic mycotoxicoses in Wistar rats: assessment of the in vivo and in vitro genotoxicity induced by fumonisins and aflatoxin B(1), and oxidative stress biomarkers status. 2010 Toxicology pmid:20015463
van der Westhuizen L et al. Disruption of sphingolipid biosynthesis in hepatocyte nodules: selective proliferative stimulus induced by fumonisin B1. 2004 Toxicology pmid:15158565
Gelderblom WC et al. Cancer initiating properties of fumonisin B1 in a short-term rat liver carcinogenesis assay. 2008 Toxicology pmid:18616970
Biswal SS et al. Changes in ceramide and sphingomyelin following fludarabine treatment of human chronic B-cell leukemia cells. 2000 Toxicology pmid:11118669
Sharma RP et al. Decreased fumonisin hepatotoxicity in mice with a targeted deletion of tumor necrosis factor receptor 1. 2001 Toxicology pmid:11250056
Bhandari N et al. Gender-related differences in subacute fumonisin B1 hepatotoxicity in BALB/c mice. 2001 Toxicology pmid:11522378
Mary VS et al. Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells. 2012 Toxicology pmid:22981896