fumonisin b1

fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.

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Introduction

To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with fumonisin b1?

fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with fumonisin b1

MeSH term MeSH ID Detail
Neuronal Ceroid-Lipofuscinoses D009472 5 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Paralysis D010243 4 associated lipids
Neural Tube Defects D009436 5 associated lipids
Fetal Resorption D005327 15 associated lipids
Cleft Palate D002972 9 associated lipids
Choline Deficiency D002796 16 associated lipids
Stomatitis D013280 14 associated lipids
Pneumonia, Bacterial D018410 16 associated lipids
Mycoses D009181 18 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with fumonisin b1

Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with fumonisin b1?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with fumonisin b1?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with fumonisin b1?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with fumonisin b1?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with fumonisin b1?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with fumonisin b1

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Per page 10 20 50 100 | Total 1278
Authors Title Published Journal PubMed Link
Yi F et al. Mechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: role of guanine nucleotide exchange factor Vav2. 2007 Cell. Physiol. Biochem. pmid:17982273
Schilling T and Eder C Importance of lipid rafts for lysophosphatidylcholine-induced caspase-1 activation and reactive oxygen species generation. 2010 Cell. Immunol. pmid:20832779
Shi L et al. Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. 2007 Cell Res. pmid:18059378
Aflaki E et al. C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. 2012 Cell Death Dis pmid:22419109
Lang KS et al. Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. 2004 Cell Death Differ. pmid:14615798
Appierto V et al. Involvement of c-Fos in fenretinide-induced apoptosis in human ovarian carcinoma cells. 2004 Cell Death Differ. pmid:14647238
Miguet C et al. Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. 2001 Cell Death Differ. pmid:11313706
Ciarlo L et al. Association of fission proteins with mitochondrial raft-like domains. 2010 Cell Death Differ. pmid:20075943
Gamen S et al. Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. 1998 Cell Death Differ. pmid:10200470
Spinedi A et al. Ceramide accumulation precedes caspase-dependent apoptosis in CHP-100 neuroepithelioma cells exposed to the protein phosphatase inhibitor okadaic acid. 1999 Cell Death Differ. pmid:10453072
Gopee NV and Sharma RP The mycotoxin fumonisin B1 transiently activates nuclear factor-kappaB, tumor necrosis factor alpha and caspase 3 via protein kinase Calpha-dependent pathway in porcine renal epithelial cells. 2004 Cell Biol. Toxicol. pmid:15499968
Gelderblom WC et al. Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. 1991 Carcinogenesis pmid:1649015
Gelderblom WC et al. The cancer-initiating potential of the fumonisin B mycotoxins. 1992 Carcinogenesis pmid:1547534
Lemmer ER et al. Fumonisin B1-induced hepatocellular and cholangiocellular tumors in male Fischer 344 rats: potentiating effects of 2-acetylaminofluorene on oval cell proliferation and neoplastic development in a discontinued feeding study. 2004 Carcinogenesis pmid:14988222
Lemmer ER et al. Histopathology and gene expression changes in rat liver during feeding of fumonisin B1, a carcinogenic mycotoxin produced by Fusarium moniliforme. 1999 Carcinogenesis pmid:10334199
Gelderblom WC et al. Fumonisin B1 dosimetry in relation to cancer initiation in rat liver. 1994 Carcinogenesis pmid:8313510
Pinelli E et al. Activation of mitogen-activated protein kinase by fumonisin B(1) stimulates cPLA(2) phosphorylation, the arachidonic acid cascade and cAMP production. 1999 Carcinogenesis pmid:10469611
Tolleson WH et al. Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells. 1996 Carcinogenesis pmid:8625445
Abdel Nour AM et al. Folate receptor and human reduced folate carrier expression in HepG2 cell line exposed to fumonisin B1 and folate deficiency. 2007 Carcinogenesis pmid:17615259
Ramljak D et al. A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity. 2000 Carcinogenesis pmid:10910956