| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Seizures | D012640 | 87 associated lipids |
fumonisin b1
fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.
Cross Reference
Introduction
To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with fumonisin b1?
fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Toxicol. Sci. (1)
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with fumonisin b1
PubChem Associated disorders and diseases
What pathways are associated with fumonisin b1
Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with fumonisin b1?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with fumonisin b1?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with fumonisin b1?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with fumonisin b1?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with fumonisin b1?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with fumonisin b1
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| El Bawab S et al. | Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. | 2001 | J. Biol. Chem. | pmid:11278489 |
| Meivar-Levy I and Futerman AH | Up-regulation of neutral glycosphingolipid synthesis upon long term inhibition of ceramide synthesis by fumonisin B1. | 1999 | J. Biol. Chem. | pmid:9988695 |
| Chalfant CE et al. | FAS activation induces dephosphorylation of SR proteins; dependence on the de novo generation of ceramide and activation of protein phosphatase 1. | 2001 | J. Biol. Chem. | pmid:11502750 |
| Okino N et al. | The reverse activity of human acid ceramidase. | 2003 | J. Biol. Chem. | pmid:12764132 |
| Lefrancois S et al. | The lysosomal transport of prosaposin requires the conditional interaction of its highly conserved d domain with sphingomyelin. | 2002 | J. Biol. Chem. | pmid:11856752 |
| Le Stunff H et al. | Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. | 2004 | J. Biol. Chem. | pmid:15180992 |
| Mullen TD et al. | Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events. | 2011 | J. Biol. Chem. | pmid:21388949 |
| Meivar-Levy I et al. | The role of sphingolipids in the maintenance of fibroblast morphology. The inhibition of protrusional activity, cell spreading, and cytokinesis induced by fumonisin B1 can be reversed by ganglioside GM3. | 1997 | J. Biol. Chem. | pmid:8999828 |
| de Chaves EI et al. | Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons. | 1997 | J. Biol. Chem. | pmid:9006952 |
| Wiesner DA et al. | Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by bcl-XL. | 1997 | J. Biol. Chem. | pmid:9092523 |
| Venkataraman K et al. | Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells. | 2002 | J. Biol. Chem. | pmid:12105227 |
| Nieto FL et al. | Sphingolipid metabolism is a crucial determinant of cellular fate in nonstimulated proliferating Madin-Darby canine kidney (MDCK) cells. | 2008 | J. Biol. Chem. | pmid:18625703 |
| Le Stunff H et al. | Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. | 2007 | J. Biol. Chem. | pmid:17895250 |
| Wu WI et al. | Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1. | 1995 | J. Biol. Chem. | pmid:7768913 |
| Strum JC et al. | Ceramide triggers meiotic cell cycle progression in Xenopus oocytes. A potential mediator of progesterone-induced maturation. | 1995 | J. Biol. Chem. | pmid:7768956 |
| Harel R and Futerman AH | Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons. | 1993 | J. Biol. Chem. | pmid:8314804 |
| Kim WY et al. | Inhibitor of apoptosis (IAP)-like protein lacks a baculovirus IAP repeat (BIR) domain and attenuates cell death in plant and animal systems. | 2011 | J. Biol. Chem. | pmid:21926169 |
| Tsegaye Y et al. | Arabidopsis mutants lacking long chain base phosphate lyase are fumonisin-sensitive and accumulate trihydroxy-18:1 long chain base phosphate. | 2007 | J. Biol. Chem. | pmid:17635905 |
| Schroeder JJ et al. | Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme. | 1994 | J. Biol. Chem. | pmid:8106389 |
| Williamson LC et al. | Neuronal sensitivity to tetanus toxin requires gangliosides. | 1999 | J. Biol. Chem. | pmid:10455200 |
| Liao WC et al. | Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. | 1999 | J. Biol. Chem. | pmid:10364237 |
| Humpf HU et al. | Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. | 1998 | J. Biol. Chem. | pmid:9668088 |
| Schmidt K et al. | Regulated apical secretion of zymogens in rat pancreas. Involvement of the glycosylphosphatidylinositol-anchored glycoprotein GP-2, the lectin ZG16p, and cholesterol-glycosphingolipid-enriched microdomains. | 2001 | J. Biol. Chem. | pmid:11152672 |
| Balsinde J et al. | Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis. | 1997 | J. Biol. Chem. | pmid:9252342 |
| Merrill AH et al. | Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. | 1993 | J. Biol. Chem. | pmid:8262970 |
| Schulz A et al. | The CLN9 protein, a regulator of dihydroceramide synthase. | 2006 | J. Biol. Chem. | pmid:16303764 |
| Kang YJ and Alexander JM | Alterations of the glutathione redox cycle status in fumonisin B1-treated pig kidney cells. | 1996 | J. Biochem. Toxicol. | pmid:9029270 |
| Sharma N et al. | Tumor necrosis factor alpha-mediated activation of c-Jun NH(2)-terminal kinase as a mechanism for fumonisin B(1) induced apoptosis in murine primary hepatocytes. | 2005 | J. Biochem. Mol. Toxicol. | pmid:16421893 |
| Jenkins GR et al. | Identification of fumonisin B1 as an inhibitor of argininosuccinate synthetase using fumonisin affinity chromatography and in vitro kinetic studies. | 2000 | J. Biochem. Mol. Toxicol. | pmid:11083085 |
| Tsunoda M et al. | Early fumonisin B1 toxicity in relation to disrupted sphingolipid metabolism in male BALB/c mice. | 1998 | J. Biochem. Mol. Toxicol. | pmid:9664234 |
| Boeira LS et al. | The effect of combinations of Fusarium mycotoxins (deoxynivalenol, zearalenone and fumonisin B1) on growth of brewing yeasts. | 2000 | J. Appl. Microbiol. | pmid:10747219 |
| Niderkorn V et al. | Cell wall component and mycotoxin moieties involved in the binding of fumonisin B1 and B2 by lactic acid bacteria. | 2009 | J. Appl. Microbiol. | pmid:19187153 |
| Armando MR et al. | Statistical optimization of culture conditions for biomass production of probiotic gut-borne Saccharomyces cerevisiae strain able to reduce fumonisin B1. | 2013 | J. Appl. Microbiol. | pmid:23347149 |
| Dawidziuk A et al. | Molecular diagnostics on the toxigenic potential of Fusarium spp. plant pathogens. | 2014 | J. Appl. Microbiol. | pmid:24575830 |
| Irzykowska L et al. | Genetic variation of Fusarium oxysporum isolates forming fumonisin B(1) and moniliformin. | 2012 | J. Appl. Genet. | pmid:22367665 |
| Edrington TS et al. | Acute hepatic and renal toxicity in lambs dosed with fumonisin-containing culture material. | 1995 | J. Anim. Sci. | pmid:7601785 |
| Piva A et al. | Activated carbon does not prevent the toxicity of culture material containing fumonisin B1 when fed to weanling piglets. | 2005 | J. Anim. Sci. | pmid:16024715 |
| Delgado JE and Wolt JD | Fumonisin B(1) and implications in nursery swine productivity: a quantitative exposure assessment. | 2010 | J. Anim. Sci. | pmid:20622179 |
| Gurung NK et al. | Effects of fumonisin B1-contaminated feeds on weanling angora goats. | 1998 | J. Anim. Sci. | pmid:9856397 |
| Price WD et al. | Naturally occurring toxins in feedstuffs: Center for Veterinary Medicine Perspective. | 1993 | J. Anim. Sci. | pmid:8407668 |
| Wilson TM et al. | Fumonisin mycotoxins and equine leukoencephalomalacia. | 1991 | J. Am. Vet. Med. Assoc. | pmid:2045319 |
| Ueda N et al. | Role of ceramide synthase in oxidant injury to renal tubular epithelial cells. | 2001 | J. Am. Soc. Nephrol. | pmid:11675414 |
| Pereira CL et al. | Total synthesis of the sphingolipid biosynthesis inhibitor fumonisin B(1). | 2009 | J. Am. Chem. Soc. | pmid:19354245 |
| Mahfoud R et al. | pH-dependent interaction of fumonisin B1 with cholesterol: physicochemical and molecular modeling studies at the air-water interface. | 2002 | J. Agric. Food Chem. | pmid:11782202 |
| Williams LD et al. | Fumonisin production and bioavailability to maize seedlings grown from seeds inoculated with Fusarium verticillioides and grown in natural soils. | 2006 | J. Agric. Food Chem. | pmid:16848565 |
| Wang S et al. | Rapid determination of fumonisin B1 in food samples by enzyme-linked immunosorbent assay and colloidal gold immunoassay. | 2006 | J. Agric. Food Chem. | pmid:16569033 |
| Seefelder W et al. | Determination of N-(carboxymethyl)fumonisin B(1) in corn products by liquid chromatography/electrospray ionization--mass spectrometry. | 2001 | J. Agric. Food Chem. | pmid:11368569 |
| Kulisek ES and Hazebroek JP | Comparison of extraction buffers for the detection of fumonisin B(1) in corn by immunoassay and high-performance liquid chromatography. | 2000 | J. Agric. Food Chem. | pmid:10637053 |
| Williams LD et al. | Fumonisin disruption of ceramide biosynthesis in maize roots and the effects on plant development and Fusarium verticillioides-induced seedling disease. | 2007 | J. Agric. Food Chem. | pmid:17381121 |
| Barna-Vetró I et al. | Development of a sensitive ELISA for the determination of fumonisin B(1) in cereals. | 2000 | J. Agric. Food Chem. | pmid:10898629 |