fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.
To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with fumonisin b1
Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
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There are no associated biomedical information in the current reference collection.
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Kang YJ and Alexander JM | Alterations of the glutathione redox cycle status in fumonisin B1-treated pig kidney cells. | 1996 | J. Biochem. Toxicol. | pmid:9029270 |
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Chalfant CE et al. | De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. | 2002 | J. Biol. Chem. | pmid:11801602 |
Le Stunff H et al. | Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. | 2004 | J. Biol. Chem. | pmid:15180992 |
Kroesen BJ et al. | Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. | 2001 | J. Biol. Chem. | pmid:11278517 |
Stevens VL and Tang J | Fumonisin B1-induced sphingolipid depletion inhibits vitamin uptake via the glycosylphosphatidylinositol-anchored folate receptor. | 1997 | J. Biol. Chem. | pmid:9218430 |
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Meivar-Levy I et al. | The role of sphingolipids in the maintenance of fibroblast morphology. The inhibition of protrusional activity, cell spreading, and cytokinesis induced by fumonisin B1 can be reversed by ganglioside GM3. | 1997 | J. Biol. Chem. | pmid:8999828 |
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Wang E et al. | Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. | 1991 | J. Biol. Chem. | pmid:1860857 |
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Wieder T et al. | Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine. | 1998 | J. Biol. Chem. | pmid:9556584 |
Le Stunff H et al. | Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. | 2007 | J. Biol. Chem. | pmid:17895250 |
Sofer A and Futerman AH | Cationic amphiphilic drugs inhibit the internalization of cholera toxin to the Golgi apparatus and the subsequent elevation of cyclic AMP. | 1995 | J. Biol. Chem. | pmid:7744860 |
Wu WI et al. | Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1. | 1995 | J. Biol. Chem. | pmid:7768913 |
Strum JC et al. | Ceramide triggers meiotic cell cycle progression in Xenopus oocytes. A potential mediator of progesterone-induced maturation. | 1995 | J. Biol. Chem. | pmid:7768956 |
Jarvis WD et al. | Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells. | 1996 | J. Biol. Chem. | pmid:8626522 |
Merrill AH et al. | Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. | 1995 | J. Biol. Chem. | pmid:7775441 |
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Riebeling C et al. | Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. | 2003 | J. Biol. Chem. | pmid:12912983 |
Harel R and Futerman AH | Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons. | 1993 | J. Biol. Chem. | pmid:8314804 |
Zhang Y et al. | The mycotoxin fumonisin B1 transcriptionally activates the p21 promoter through a cis-acting element containing two Sp1 binding sites. | 1999 | J. Biol. Chem. | pmid:10212208 |
Kim WY et al. | Inhibitor of apoptosis (IAP)-like protein lacks a baculovirus IAP repeat (BIR) domain and attenuates cell death in plant and animal systems. | 2011 | J. Biol. Chem. | pmid:21926169 |
Schwarz A et al. | A regulatory role for sphingolipids in neuronal growth. Inhibition of sphingolipid synthesis and degradation have opposite effects on axonal branching. | 1995 | J. Biol. Chem. | pmid:7738041 |
Kitatani K et al. | Mechanism of inhibition of sequestration of protein kinase C alpha/betaII by ceramide. Roles of ceramide-activated protein phosphatases and phosphorylation/dephosphorylation of protein kinase C alpha/betaII on threonine 638/641. | 2007 | J. Biol. Chem. | pmid:17504762 |
Tsegaye Y et al. | Arabidopsis mutants lacking long chain base phosphate lyase are fumonisin-sensitive and accumulate trihydroxy-18:1 long chain base phosphate. | 2007 | J. Biol. Chem. | pmid:17635905 |
Schroeder JJ et al. | Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme. | 1994 | J. Biol. Chem. | pmid:8106389 |
Williamson LC et al. | Neuronal sensitivity to tetanus toxin requires gangliosides. | 1999 | J. Biol. Chem. | pmid:10455200 |
Liao WC et al. | Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase. | 1999 | J. Biol. Chem. | pmid:10364237 |
Humpf HU et al. | Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. | 1998 | J. Biol. Chem. | pmid:9668088 |
Hidari KIPJ S et al. | Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells. | 1996 | J. Biol. Chem. | pmid:8662871 |
Schmidt K et al. | Regulated apical secretion of zymogens in rat pancreas. Involvement of the glycosylphosphatidylinositol-anchored glycoprotein GP-2, the lectin ZG16p, and cholesterol-glycosphingolipid-enriched microdomains. | 2001 | J. Biol. Chem. | pmid:11152672 |
Becker KP et al. | Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. | 2005 | J. Biol. Chem. | pmid:15546881 |
Balsinde J et al. | Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis. | 1997 | J. Biol. Chem. | pmid:9252342 |
Cuvillier O et al. | Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. | 2000 | J. Biol. Chem. | pmid:10747891 |
Mao C et al. | Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity. | 2000 | J. Biol. Chem. | pmid:10702247 |
Merrill AH et al. | Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. | 1993 | J. Biol. Chem. | pmid:8262970 |
Schulz A et al. | The CLN9 protein, a regulator of dihydroceramide synthase. | 2006 | J. Biol. Chem. | pmid:16303764 |
Hernández-Corbacho MJ et al. | Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death. | 2015 | J. Biol. Chem. | pmid:26318452 |