fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.
To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with fumonisin b1
Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Guzman RE et al. | Chronic consumption of fumonisins derived from Fusarium moniliforme culture material: clinical and pathologic effects in swine. | 1997 | J. Vet. Diagn. Invest. | pmid:9211249 |
Wilson TM et al. | Fumonisin B1 levels associated with an epizootic of equine leukoencephalomalacia. | 1990 | J. Vet. Diagn. Invest. | pmid:2094447 |
Harrison LR et al. | Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. | 1990 | J. Vet. Diagn. Invest. | pmid:2094448 |
Wilson TM et al. | A mycological evaluation and in vivo toxicity evaluation of feed from 41 farms with equine leukoencephalomalacia. | 1990 | J. Vet. Diagn. Invest. | pmid:2095286 |
Ross PF et al. | Fumonisin B1 concentrations in feeds from 45 confirmed equine leukoencephalomalacia cases. | 1991 | J. Vet. Diagn. Invest. | pmid:1911996 |
Plattner RD et al. | Analysis of corn and cultured corn for fumonisin B1 by HPLC and GC/MS by four laboratories. | 1991 | J. Vet. Diagn. Invest. | pmid:1760472 |
Rottinghaus GE et al. | A rapid, sensitive thin layer chromatography procedure for the detection of fumonisin B1 and B2. | 1992 | J. Vet. Diagn. Invest. | pmid:1515494 |
Ledoux DR et al. | Fumonisin toxicity in broiler chicks. | 1992 | J. Vet. Diagn. Invest. | pmid:1515495 |
Brown DW et al. | Experimental feeding of Fusarium moniliforme culture material containing fumonisin B1 to channel catfish, Ictalurus punctatus. | 1994 | J. Vet. Diagn. Invest. | pmid:8011771 |
Hall JO et al. | Serum vitamin A (retinol) reduction in broiler chicks on feed amended with Fusarium proliferatum culture material or fumonisin B1 and moniliformin. | 1995 | J. Vet. Diagn. Invest. | pmid:7578467 |
Baker DC and Rottinghaus GE | Chronic experimental fumonisin intoxication of calves. | 1999 | J. Vet. Diagn. Invest. | pmid:10353364 |
Casteel SW et al. | Chronic toxicity of fumonisin in weanling pigs. | 1993 | J. Vet. Diagn. Invest. | pmid:8373857 |
Hsiao SH et al. | Use of formalin-fixed tissues to determine fumonisin B1-induced sphingolipid alterations in swine. | 2007 | J. Vet. Diagn. Invest. | pmid:17609357 |
Javed T et al. | Serohematologic alterations in broiler chicks on feed amended with Fusarium proliferatum culture material on fumonisin B1 and moniliformin. | 1995 | J. Vet. Diagn. Invest. | pmid:8580176 |
Colvin BM et al. | Fumonisin toxicosis in swine: clinical and pathologic findings. | 1993 | J. Vet. Diagn. Invest. | pmid:8507702 |
Ross PF et al. | Experimental equine leukoencephalomalacia, toxic hepatosis, and encephalopathy caused by corn naturally contaminated with fumonisins. | 1993 | J. Vet. Diagn. Invest. | pmid:8466984 |
Weibking TS et al. | Fumonisin toxicity in turkey poults. | 1993 | J. Vet. Diagn. Invest. | pmid:8466985 |
Foreman JH et al. | Neurologic abnormalities and cerebrospinal fluid changes in horses administered fumonisin B1 intravenously. | 2004 Mar-Apr | J. Vet. Intern. Med. | pmid:15058775 |
Plumlee KH and Galey FD | Neurotoxic mycotoxins: a review of fungal toxins that cause neurological disease in large animals. | 1994 Jan-Feb | J. Vet. Intern. Med. | pmid:8176663 |
Zomborszky-Kovács M et al. | Effects of prolonged exposure to low-dose fumonisin B1 in pigs. | 2002 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:12069274 |
Zomborszky MK et al. | Experiment to determine limits of tolerance for fumonisin B1 in weaned piglets. | 2000 | J. Vet. Med. B Infect. Dis. Vet. Public Health | pmid:10861196 |
Sozmen M et al. | Protective effects of silymarin on fumonisin Bâ‚-induced hepatotoxicity in mice. | 2014 | J. Vet. Sci. | pmid:24136215 |
Yi F et al. | Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells. | 2004 | Kidney Int. | pmid:15496169 |
Ueda N et al. | Role of enhanced ceramide generation in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells. | 1998 | Kidney Int. | pmid:9690206 |
Itoh Y et al. | Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury. | 2006 | Kidney Int. | pmid:16408118 |
León-S FE et al. | Mycotoxins in myelopathies of man. | 1996 | Lancet | pmid:8855894 |
Melcion D et al. | Study of the biosynthesis of fumonisins B1, B2 and B3 by different strains of Fusarium moniliforme. | 1997 | Lett. Appl. Microbiol. | pmid:9134779 |
Hu LB et al. | Inhibition of fengycins on the production of fumonisin B1 from Fusarium verticillioides. | 2009 | Lett. Appl. Microbiol. | pmid:19018959 |
Dissanayake ML et al. | Fumonisin B(1) production by Fusarium proliferatum strains isolated from Allium fistulosum plants and seeds in Japan. | 2009 | Lett. Appl. Microbiol. | pmid:19416462 |
Chatterjee D et al. | Nuclear disintegration in chicken peritoneal macrophages exposed to fumonisin B1 from Indian maize. | 1995 | Lett. Appl. Microbiol. | pmid:7766078 |
Cahagnier B et al. | Growth of Fusarium moniliforme and its biosynthesis of fumonisin B1 on maize grain as a function of different water activities. | 1995 | Lett. Appl. Microbiol. | pmid:7766121 |
Cavaglieri L et al. | In vitro influence of bacterial mixtures on Fusarium verticillioides growth and fumonisin B1 production: effect of seeds treatment on maize root colonization. | 2005 | Lett. Appl. Microbiol. | pmid:16238641 |
Marin S et al. | Effect of water activity and temperature on growth and fumonisin B1 and B2 production by Fusarium proliferatum and F. moniliforme on maize grain. | 1995 | Lett. Appl. Microbiol. | pmid:7576524 |
He Q et al. | Fumonisin B(1) alters sphingolipid metabolism and tumor necrosis factor alpha expression in heart and lung of mice. | 2002 | Life Sci. | pmid:12175895 |
Gopee NV and Sharma RP | Selective and transient activation of protein kinase C alpha by fumonisin B1, a ceramide synthase inhibitor mycotoxin, in cultured porcine renal cells. | 2004 | Life Sci. | pmid:14729403 |
Meli R et al. | Effect of fumonisin B1 on inducible nitric oxide synthase and cyclooxygenase-2 in LPS-stimulated J774A.1 cells. | 2000 | Life Sci. | pmid:11105999 |
Kaneshiro T et al. | 2-Hydroxyhexadecanoic and 8,9,13-trihydroxydocosanoic acid accumulation by yeasts treated with fumonisin B1. | 1993 | Lipids | pmid:8316046 |
Gelderblom WC et al. | Lipids and delta6-desaturase activity alterations in rat liver microsomal membranes induced by fumonisin B1. | 2002 | Lipids | pmid:12458622 |
Alessenko AV and Khrenov AV | Role of sphingosine in induced apoptosis. | 1999 | Lipids | pmid:10419095 |
Burger HM et al. | Altered lipid parameters in hepatic subcellular membrane fractions induced by fumonisin B1. | 2007 | Lipids | pmid:17393230 |
Andersen AJC et al. | HPLC-HRMS Quantification of the Ichthyotoxin Karmitoxin from Karlodinium armiger. | 2017 | Mar Drugs | pmid:28858210 |
Xiao-Yun X et al. | Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells. | 2009 | Med. Sci. Monit. | pmid:19721393 |
Auzenne E et al. | Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro. | 1998 | Melanoma Res. | pmid:9664144 |
Riley RT and Plattner RD | Fermentation, partial purification, and use of serine palmitoyltransferase inhibitors from Isaria (= Cordyceps) sinclairii. | 2000 | Meth. Enzymol. | pmid:10563339 |
Taitt CR et al. | Surface modification and biomolecule immobilization on polymer spheres for biosensing applications. | 2011 | Methods Mol. Biol. | pmid:21424444 |
Muscarella M et al. | Determination of fumonisins Bâ‚ and Bâ‚‚ in maize food products by a new analytical method based on high-performance liquid chromatography and fluorimetric detection with post-column derivatization. | 2011 | Methods Mol. Biol. | pmid:21567328 |
Eppley RM | Preparatory isolation of mycotoxins from solid phase fungal cultures. | 2001 | Methods Mol. Biol. | pmid:11050990 |
Wilkes JG and Lay JO | Electrospray mass spectrometry for mycotoxin detection and purity analysis. | 2001 | Methods Mol. Biol. | pmid:11050992 |
Shephard GS | Liquid chromatographic method for fumonisins in corn. | 2001 | Methods Mol. Biol. | pmid:11051000 |
Hartinger D et al. | Enhancement of solubility in Escherichia coli and purification of an aminotransferase from Sphingopyxis sp. MTA144 for deamination of hydrolyzed fumonisin B(1). | 2010 | Microb. Cell Fact. | pmid:20718948 |
Kubo T et al. | Chlamydia trachomatis serovar L2 infection model using human lymphoid Jurkat cells. | 2012 | Microb. Pathog. | pmid:22516802 |
Shimamoto S et al. | Changes in ganglioside content affect the binding of Clostridium perfringens epsilon-toxin to detergent-resistant membranes of Madin-Darby canine kidney cells. | 2005 | Microbiol. Immunol. | pmid:15781998 |
Kim H et al. | HXK1 regulates carbon catabolism, sporulation, fumonisin Bâ‚ production and pathogenesis in Fusarium verticillioides. | 2011 | Microbiology (Reading, Engl.) | pmid:21719539 |
Choi YE and Shim WB | Functional characterization of Fusarium verticillioides CPP1, a gene encoding a putative protein phosphatase 2A catalytic subunit. | 2008 | Microbiology (Reading, Engl.) | pmid:18174151 |
Wang SK et al. | Effect of fumonisin Bâ‚ on the cell cycle of normal human liver cells. | 2013 | Mol Med Rep | pmid:23625282 |
Voss KA et al. | Fumonisin Bâ‚ induced neural tube defects were not increased in LM/Bc mice fed folate-deficient diet. | 2014 | Mol Nutr Food Res | pmid:24585430 |
Torres O et al. | Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala. | 2014 | Mol Nutr Food Res | pmid:24375966 |
Voss KA et al. | Extrusion cooking with glucose supplementation of fumonisin-contaminated corn grits protects against nephrotoxicity and disrupted sphingolipid metabolism in rats. | 2011 | Mol Nutr Food Res | pmid:21648070 |
Riley RT et al. | The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets. | 2012 | Mol Nutr Food Res | pmid:22815244 |
Seiferlein M et al. | Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites. | 2007 | Mol Nutr Food Res | pmid:17729221 |
Pellanda H et al. | Fumonisin FB1 treatment acts synergistically with methyl donor deficiency during rat pregnancy to produce alterations of H3- and H4-histone methylation patterns in fetuses. | 2012 | Mol Nutr Food Res | pmid:22707272 |
Harrer H et al. | Identification of N-acyl-fumonisin B1 as new cytotoxic metabolites of fumonisin mycotoxins. | 2013 | Mol Nutr Food Res | pmid:23281112 |
Marin DE et al. | Fumonisin B1 alters cell cycle progression and interleukin-2 synthesis in swine peripheral blood mononuclear cells. | 2007 | Mol Nutr Food Res | pmid:17918165 |
Shirima CP et al. | Dietary exposure to aflatoxin and fumonisin among Tanzanian children as determined using biomarkers of exposure. | 2013 | Mol Nutr Food Res | pmid:23776058 |
Bouhet S and Oswald IP | The intestine as a possible target for fumonisin toxicity. | 2007 | Mol Nutr Food Res | pmid:17642075 |
Domijan AM et al. | The involvement of oxidative stress in ochratoxin A and fumonisin B1 toxicity in rats. | 2007 | Mol Nutr Food Res | pmid:17688296 |
Riley RT et al. | Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. | 2015 | Mol Nutr Food Res | pmid:26264677 |
Gerding J et al. | Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach. | 2014 | Mol Nutr Food Res | pmid:25243722 |
Li J et al. | Kunitz trypsin inhibitor: an antagonist of cell death triggered by phytopathogens and fumonisin b1 in Arabidopsis. | 2008 | Mol Plant | pmid:19825555 |
Figueiredo JM et al. | Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi. | 2012 Mar-Apr | Mol. Biochem. Parasitol. | pmid:22226824 |
Sandvig K et al. | Importance of glycolipid synthesis for butyric acid-induced sensitization to shiga toxin and intracellular sorting of toxin in A431 cells. | 1996 | Mol. Biol. Cell | pmid:8885234 |
Van IJzendoorn SC et al. | Polarized membrane traffic and cell polarity development is dependent on dihydroceramide synthase-regulated sphinganine turnover. | 2004 | Mol. Biol. Cell | pmid:15229289 |
Schorling S et al. | Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. | 2001 | Mol. Biol. Cell | pmid:11694577 |
Lipardi C et al. | Detergent-insoluble GPI-anchored proteins are apically sorted in fischer rat thyroid cells, but interference with cholesterol or sphingolipids differentially affects detergent insolubility and apical sorting. | 2000 | Mol. Biol. Cell | pmid:10679012 |
Smith SJ et al. | A Novel Function for Arabidopsis CYCLASE1 in Programmed Cell Death Revealed by Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) Analysis of Extracellular Matrix Proteins. | 2015 | Mol. Cell Proteomics | pmid:25862728 |
Chivasa S et al. | Proteomic analysis of extracellular ATP-regulated proteins identifies ATP synthase beta-subunit as a novel plant cell death regulator. | 2011 | Mol. Cell Proteomics | pmid:21156838 |
Ghosh S et al. | Generation of ceramide in murine macrophages infected with Leishmania donovani alters macrophage signaling events and aids intracellular parasitic survival. | 2001 | Mol. Cell. Biochem. | pmid:11681721 |
Giussani P et al. | Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. | 2006 | Mol. Cell. Biol. | pmid:16782891 |
Laudati E et al. | The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains. | 2016 | Mol. Cell. Neurosci. | pmid:27565578 |
Chang MC et al. | Inhibition of sphingolipid synthesis affects kinetics but not fidelity of L1/NgCAM transport along direct but not transcytotic axonal pathways. | 2006 | Mol. Cell. Neurosci. | pmid:16376103 |
Hayashi T and Fujimoto M | Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junction. | 2010 | Mol. Pharmacol. | pmid:20053954 |
Brandwagt BF et al. | Overexpression of the tomato Asc-1 gene mediates high insensitivity to AAL toxins and fumonisin B1 in tomato hairy roots and confers resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica plants. | 2002 | Mol. Plant Microbe Interact. | pmid:11858172 |
Wang L et al. | OsLSD1, a rice zinc finger protein, regulates programmed cell death and callus differentiation. | 2005 | Mol. Plant Microbe Interact. | pmid:15915636 |
Bluhm BH and Woloshuk CP | Amylopectin induces fumonisin B1 production by Fusarium verticillioides during colonization of maize kernels. | 2005 | Mol. Plant Microbe Interact. | pmid:16478053 |
Desjardins AE et al. | FUM1--a gene required for fumonisin biosynthesis but not for maize ear rot and ear infection by Gibberella moniliformis in field tests. | 2002 | Mol. Plant Microbe Interact. | pmid:12423021 |
Niu C et al. | Involvement of FST1 from Fusarium verticillioides in virulence and transport of inositol. | 2017 | Mol. Plant Pathol. | pmid:27195938 |
Oh M et al. | Transcription factor ART1 mediates starch hydrolysis and mycotoxin production in Fusarium graminearum and F. verticillioides. | 2016 | Mol. Plant Pathol. | pmid:26456718 |
Ehrlich V et al. | Fumonisin B(1) is genotoxic in human derived hepatoma (HepG2) cells. | 2002 | Mutagenesis | pmid:11971998 |
Aranda M et al. | Assessment of in vitro mutagenicity in Salmonella and in vivo genotoxicity in mice of the mycotoxin fumonisin B(1). | 2000 | Mutagenesis | pmid:11076997 |
Knasmüller S et al. | Genotoxic effects of three Fusarium mycotoxins, fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes. | 1997 | Mutat. Res. | pmid:9219547 |
Turner PC et al. | Fumonisin contamination of food: progress in development of biomarkers to better assess human health risks. | 1999 | Mutat. Res. | pmid:10415433 |
Castellá G et al. | Mycoflora and fumonisin-producing strains of Fusarium moniliforme in mixed poultry feeds and component raw material. | 1996 | Mycopathologia | pmid:8927120 |
Javed T et al. | Comparative pathologic changes in broiler chicks on feed amended with Fusarium proliferatum culture material or purified fumonisin B1 and moniliformin. | 2005 | Mycopathologia | pmid:15983742 |
Yazdanpanah H et al. | Human dietary exposure to fumonisin B1 from Iranian maize harvested during 1998-2000. | 2006 | Mycopathologia | pmid:16761187 |
Norred WP et al. | In vitro toxicology of fumonisins and the mechanistic implications. | 1992 | Mycopathologia | pmid:1513375 |
Colvin BM and Harrison LR | Fumonisin-induced pulmonary edema and hydrothorax in swine. | 1992 | Mycopathologia | pmid:1513376 |
Voss KA et al. | Subchronic toxicological investigations of Fusarium moniliforme-contaminated corn, culture material, and ammoniated culture material. | 1992 | Mycopathologia | pmid:1513377 |
Haschek WM et al. | Characterization of fumonisin toxicity in orally and intravenously dosed swine. | 1992 | Mycopathologia | pmid:1387461 |
Javed T et al. | Embryopathic and embryocidal effects of purified fumonisin B1 or Fusarium proliferatum culture material extract on chicken embryos. | 1993 | Mycopathologia | pmid:8302367 |
Branham BE and Plattner RD | Alanine is a precursor in the biosynthesis of fumonisin B1 by Fusarium moniliforme. | 1993 | Mycopathologia | pmid:8008046 |