fumonisin b1

fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.

Cross Reference

Introduction

To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with fumonisin b1?

fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with fumonisin b1

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Inflammation D007249 119 associated lipids
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Esophageal Neoplasms D004938 20 associated lipids
Precancerous Conditions D011230 48 associated lipids
Per page 10 20 50 100 | Total 54

PubChem Associated disorders and diseases

What pathways are associated with fumonisin b1

Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with fumonisin b1?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with fumonisin b1?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with fumonisin b1?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with fumonisin b1?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with fumonisin b1?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with fumonisin b1

Download all related citations
Per page 10 20 50 100 | Total 1278
Authors Title Published Journal PubMed Link
Osuchowski MF and Sharma RP Fumonisin B1 induces necrotic cell death in BV-2 cells and murine cultured astrocytes and is antiproliferative in BV-2 cells while N2A cells and primary cortical neurons are resistant. 2005 Neurotoxicology pmid:16005069
Saucedo-García M et al. MPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis. 2011 New Phytol. pmid:21534970
Wolf G Inhibition of cellular uptake of folate by blocking synthesis of the membrane folate receptor. 1998 Nutr. Rev. pmid:9564182
Wolf G Mechanism of the mitogenic and carcinogenic action of fumonisin B1, a mycotoxin. 1994 Nutr. Rev. pmid:8090377
White-Gilbertson S et al. Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. 2009 Oncogene pmid:19137010
Kellerman TS et al. Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. 1990 Onderstepoort J. Vet. Res. pmid:2293136
Marasas WF et al. Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. 1988 Onderstepoort J. Vet. Res. pmid:3217091
Hwang D et al. Effects of ceramide inhibition on experimental radiation-induced oral mucositis. 2005 Oral Surg Oral Med Oral Pathol Oral Radiol Endod pmid:16122660
Nogueira TC et al. Involvement of phosphatidylinositol-3 kinase/AKT/PKCzeta/lambda pathway in the effect of palmitate on glucose-induced insulin secretion. 2008 Pancreas pmid:18815554
Mazzoni E et al. Field control of Fusarium ear rot, Ostrinia nubilalis (Hübner), and fumonisins in maize kernels. 2011 Pest Manag. Sci. pmid:21394878
Demirel G et al. Role of fumonisin B1 on DNA methylation changes in rat kidney and liver cells. 2015 Pharm Biol pmid:25858139
Eichele K et al. R(+)-methanandamide-induced apoptosis of human cervical carcinoma cells involves a cyclooxygenase-2-dependent pathway. 2009 Pharm. Res. pmid:19015962
Atroshi F et al. Fumonisin B1-induced DNA damage in rat liver and spleen: effects of pretreatment with coenzyme Q10, L-carnitine, alpha-tocopherol and selenium. 1999 Pharmacol. Res. pmid:10660942
Atroshi F et al. Effects of tamoxifen, melatonin, coenzyme Q10, and L-carnitine supplementation on bacterial growth in the presence of mycotoxins. 1998 Pharmacol. Res. pmid:9774492
Dutton MF Fumonisins, mycotoxins of increasing importance: their nature and their effects. 1996 Pharmacol. Ther. pmid:8843466
He Q et al. Pharmacological antagonism of fumonisin B1 cytotoxicity in porcine renal epithelial cells (LLC-PK1): a model for reducing fumonisin-induced nephrotoxicity in vivo. 2002 Pharmacol. Toxicol. pmid:12076308
Boppana NB et al. Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization. 2014 Photochem. Photobiol. Sci. pmid:25266739
Szabó A et al. Oral administration of fumonisin B and T-2 individually and in combination affects hepatic total and mitochondrial membrane lipid profile of rabbits. 2016 Physiol Int pmid:28229635
Arias SL et al. Toxin distribution and sphingoid base imbalances in Fusarium verticillioides-infected and fumonisin B1-watered maize seedlings. 2016 Phytochemistry pmid:26903312
Abbas HK et al. Biological activities of synthetic analogues of Alternaria alternata toxin (AAL-toxin) and fumonisin in plant and mammalian cell cultures. 1995 Phytochemistry pmid:8590636
Desjardins AE et al. Identification and heritability of fumonisin insensitivity in Zea mays. 2005 Phytochemistry pmid:16198380
Markham JE et al. Sphingolipids containing very-long-chain fatty acids define a secretory pathway for specific polar plasma membrane protein targeting in Arabidopsis. 2011 Plant Cell pmid:21666002
Chivasa S et al. Extracellular ATP functions as an endogenous external metabolite regulating plant cell viability. 2005 Plant Cell pmid:16199612
Asai T et al. Fumonisin B1-induced cell death in arabidopsis protoplasts requires jasmonate-, ethylene-, and salicylate-dependent signaling pathways. 2000 Plant Cell pmid:11041879
Kimberlin AN et al. Arabidopsis 56-amino acid serine palmitoyltransferase-interacting proteins stimulate sphingolipid synthesis, are essential, and affect mycotoxin sensitivity. 2013 Plant Cell pmid:24214397
Stone JM et al. Simulation of fungal-mediated cell death by fumonisin B1 and selection of fumonisin B1-resistant (fbr) Arabidopsis mutants. 2000 Plant Cell pmid:11041878
Basnayake BM et al. Arabidopsis DAL1 and DAL2, two RING finger proteins homologous to Drosophila DIAP1, are involved in regulation of programmed cell death. 2011 Plant Cell Rep. pmid:20972793
Zhao Y et al. Classic myrosinase-dependent degradation of indole glucosinolate attenuates fumonisin B1-induced programmed cell death in Arabidopsis. 2015 Plant J. pmid:25645692
Stone JM et al. Arabidopsis AtSPL14, a plant-specific SBP-domain transcription factor, participates in plant development and sensitivity to fumonisin B1. 2005 Plant J. pmid:15703061
Bindschedler LV et al. Peroxidase-dependent apoplastic oxidative burst in Arabidopsis required for pathogen resistance. 2006 Plant J. pmid:16889645
Watanabe N and Lam E Arabidopsis Bax inhibitor-1 functions as an attenuator of biotic and abiotic types of cell death. 2006 Plant J. pmid:16507080
Aubert A et al. Sphingolipids involvement in plant endomembrane differentiation: the BY2 case. 2011 Plant J. pmid:21205030
Lin SS et al. RING1 E3 ligase localizes to plasma membrane lipid rafts to trigger FB1-induced programmed cell death in Arabidopsis. 2008 Plant J. pmid:18643987
Lenz HD et al. Autophagy differentially controls plant basal immunity to biotrophic and necrotrophic pathogens. 2011 Plant J. pmid:21332848
Luttgeharm KD et al. Overexpression of Arabidopsis Ceramide Synthases Differentially Affects Growth, Sphingolipid Metabolism, Programmed Cell Death, and Mycotoxin Resistance. 2015 Plant Physiol. pmid:26276842
Feng H et al. Functional characterization of the Arabidopsis eukaryotic translation initiation factor 5A-2 that plays a crucial role in plant growth and development by regulating cell division, cell growth, and cell death. 2007 Plant Physiol. pmid:17513484
Qin X et al. Sphingosine kinase AtSPHK1 functions in fumonisin B1-triggered cell death in Arabidopsis. 2017 Plant Physiol. Biochem. pmid:28846870
Lenz HD et al. ATG7 contributes to plant basal immunity towards fungal infection. 2011 Plant Signal Behav pmid:21617379
Saucedo-García M et al. Reactive oxygen species as transducers of sphinganine-mediated cell death pathway. 2011 Plant Signal Behav pmid:21921699
Gutiérrez-Nájera N et al. Fumonisin B1, a sphingoid toxin, is a potent inhibitor of the plasma membrane H+-ATPase. 2005 Planta pmid:15703925
Sánchez-Rangel D et al. Fumonisin B1, a toxin produced by Fusarium verticillioides, modulates maize β-1,3-glucanase activities involved in defense response. 2012 Planta pmid:22120123
De Jong AJ et al. Chemical-induced apoptotic cell death in tomato cells: involvement of caspase-like proteases. 2000 Planta pmid:11089678
Shin KO et al. Terpene alcohols inhibit de novo sphingolipid biosynthesis. 2012 Planta Med. pmid:22274813
Liao YJ et al. Inhibition of fumonisin B1 cytotoxicity by nanosilicate platelets during mouse embryo development. 2014 PLoS ONE pmid:25383881
He S et al. The LSD1-interacting protein GILP is a LITAF domain protein that negatively regulates hypersensitive cell death in Arabidopsis. 2011 PLoS ONE pmid:21526181
Kacprzyk J et al. The root hair assay facilitates the use of genetic and pharmacological tools in order to dissect multiple signalling pathways that lead to programmed cell death. 2014 PLoS ONE pmid:24755572
Lee H et al. Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation. 2011 PLoS ONE pmid:21695182
Malapi-Wight M et al. Sda1, a Cys2-His2 zinc finger transcription factor, is involved in polyol metabolism and fumonisin B1 production in Fusarium verticillioides. 2013 PLoS ONE pmid:23844049
Czembor E et al. Effect of Environmental Factors on Fusarium Species and Associated Mycotoxins in Maize Grain Grown in Poland. 2015 PLoS ONE pmid:26225823
Agostini F et al. Prion protein accumulation in lipid rafts of mouse aging brain. 2013 PLoS ONE pmid:24040215
Igarashi D et al. Pattern-triggered immunity suppresses programmed cell death triggered by fumonisin b1. 2013 PLoS ONE pmid:23560104
Broomhead JN et al. Chronic effects of fumonisin B1 in broilers and turkeys fed dietary treatments to market age. 2002 Poult. Sci. pmid:11885900
Vesonder RF and Wu W Correlation of moniliformin, but not fumonisin B1 levels, in culture materials of Fusarium isolates to acute death in ducklings. 1998 Poult. Sci. pmid:9469753
Henry MH and Wyatt RD The toxicity of fumonisin B1, B2, and B3, individually and in combination, in chicken embryos. 2001 Poult. Sci. pmid:11297276
Siloto EV et al. Lipid metabolism of commercial layers fed diets containing aflatoxin, fumonisin, and a binder. 2013 Poult. Sci. pmid:23873555
Rossi F et al. Effect of Bt corn on broiler growth performance and fate of feed-derived DNA in the digestive tract. 2005 Poult. Sci. pmid:16050119
Weibking TS et al. Individual and combined effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, and aflatoxin B1 in the young turkey poult. 1994 Poult. Sci. pmid:7816726
Miazzo R et al. Efficacy of sodium bentonite as a detoxifier of broiler feed contaminated with aflatoxin and fumonisin. 2005 Poult. Sci. pmid:15685935
Henry MH et al. The toxicity of purified fumonisin B1 in broiler chicks. 2000 Poult. Sci. pmid:11055840
Ledoux DR et al. Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, in the young turkey poult. 1996 Poult. Sci. pmid:9000269
Keck BB and Bodine AB The effects of fumonisin B1 on viability and mitogenic response of avian immune cells. 2006 Poult. Sci. pmid:16776470
Asrani RK et al. Effects of feeding Fusarium verticillioides (formerly Fusarium moniliforme) culture material containing known levels of fumonisin B1 in Japanese quail (Coturnix coturnix japonica). 2006 Poult. Sci. pmid:16830851
Del Bianchi M et al. Effects of prolonged oral administration of aflatoxin B1 and fumonisin B1 in broiler chickens. 2005 Poult. Sci. pmid:16479938
Tardieu D et al. Toxicity of maize containing known levels of fumonisin B1 during force-feeding of ducks. 2004 Poult. Sci. pmid:15339002
Qureshi MA and Hagler WM Effect of fumonisin-B1 exposure on chicken macrophage functions in vitro. 1992 Poult. Sci. pmid:1539010
Kubena LF et al. Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and diacetoxyscirpenol or ochratoxin A in turkey poults. 1997 Poult. Sci. pmid:9057204
Sharma D et al. Individual and combined effects of fumonisin b1 and moniliformin on clinicopathological and cell-mediated immune response in Japanese quail. 2008 Poult. Sci. pmid:18492990
Kubena LF et al. Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and T-2 toxin or deoxynivalenol in broiler chicks. 1997 Poult. Sci. pmid:9276886
Kubena LF et al. Effects of long-term feeding of diets containing moniliformin, supplied by Fusarium fujikuroi culture material, and fumonisin, supplied by Fusarium moniliforme culture material, to laying hens. 1999 Poult. Sci. pmid:10560820
Kubena LF et al. Influence of fumonisin B1, present in Fusarium moniliforme culture material, and T-2 toxin on turkey poults. 1995 Poult. Sci. pmid:7724453
Li YC et al. Effects of fumonisin B1 on selected immune responses in broiler chicks. 1999 Poult. Sci. pmid:10515357
Tran ST et al. Chronic effects of fumonisin B1 on ducks. 2005 Poult. Sci. pmid:15685938
Li YC et al. The individual and combined effects of fumonisin B1 and moniliformin on performance and selected immune parameters in turkey poults. 2000 Poult. Sci. pmid:10875770
Weibking TS et al. Effects of feeding Fusarium moniliforme culture material, containing known levels of fumonisin B1, on the young broiler chick. 1993 Poult. Sci. pmid:8464788
Ogido R et al. Effects of prolonged administration of aflatoxin B1 and fumonisin B1 in laying Japanese quail. 2004 Poult. Sci. pmid:15615006
Rauber RH et al. Individual and combined effects of Salmonella typhimurium lipopolysaccharide and fumonisin B1 in broiler chickens. 2012 Poult. Sci. pmid:23091133
Kubena LF et al. Effects of feeding fumonisin B1 present in Fusarium moniliforme culture material and aflatoxin singly and in combination to turkey poults. 1995 Poult. Sci. pmid:7479507
Wu W et al. The effect of fumonisin B1 on isolated chondrocytes and on bone formation. 1995 Poult. Sci. pmid:7501587
Khalil AA et al. Protective role of probiotic lactic acid bacteria against dietary fumonisin B1-induced toxicity and DNA-fragmentation in sprague-dawley rats. 2015 Prep. Biochem. Biotechnol. pmid:25036875
Kononenko GP et al. [Application of competitive immunoenzyme assay for analysis of group B fumonisins]. 1999 Mar-Apr Prikl. Biokhim. Mikrobiol. pmid:10368851
Brandwagt BF et al. A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10781105
Wang W et al. Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8622958
De Nadai C et al. Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. 2000 Proc. Natl. Acad. Sci. U.S.A. pmid:10792026
Porter JK et al. Effects of Fusarium moniliforme and corn associated with equine leukoencephalomalacia on rat neurotransmitters and metabolites. 1990 Proc. Soc. Exp. Biol. Med. pmid:1972578
Porter JK et al. Neurotransmitters in rats fed fumonisin B1. 1993 Proc. Soc. Exp. Biol. Med. pmid:7679795
Soriano JM et al. Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1. 2005 Prog. Lipid Res. pmid:16266752
Gelderblom WC et al. Regulation of fatty acid biosynthesis as a possible mechanism for the mitoinhibitory effect of fumonisin B1 in primary rat hepatocytes. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10574646
Seegers JC et al. Fumonisin B1 influenced the effects of arachidonic acid, prostaglandins E2 and A2 on cell cycle progression, apoptosis induction, tyrosine- and CDC2-kinase activity in oesophageal cancer cells. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10780872
Hines HB et al. Fumonisin B1 analysis with capillary electrophoresis-electrospray ionization mass spectrometry. 1995 Rapid Commun. Mass Spectrom. pmid:7606046
Paepens C et al. Development of a liquid chromatography/tandem mass spectrometry method for the quantification of fumonisin B1, B2 and B3 in cornflakes. 2005 Rapid Commun. Mass Spectrom. pmid:15973649
Korfmacher WA et al. Characterization of the mycotoxin fumonisin B1: comparison of thermospray, fast-atom bombardment and electrospray mass spectrometry. 1991 Rapid Commun. Mass Spectrom. pmid:1841646
Bartók T et al. Detection and characterization of twenty-eight isomers of fumonisin B1 (FB1) mycotoxin in a solid rice culture infected with Fusarium verticillioides by reversed-phase high-performance liquid chromatography/electrospray ionization time-of-flight and ion trap mass spectrometry. 2010 Rapid Commun. Mass Spectrom. pmid:19960490
Josephs JL Detection and characterization of fumonisin mycotoxins by liquid chromatography/electrospray ionization using ion trap and triple quadrupole mass spectrometry. 1996 Rapid Commun. Mass Spectrom. pmid:8805843
Kalo D and Roth Z Involvement of the sphingolipid ceramide in heat-shock-induced apoptosis of bovine oocytes. 2011 Reprod. Fertil. Dev. pmid:21871207
Ewuola EO and Egbunike GN Effects of dietary fumonisin B1 on the onset of puberty, semen quality, fertility rates and testicular morphology in male rabbits. 2010 Reproduction pmid:19917669
Cavaglieri L et al. Screening procedures for selecting rhizobacteria with biocontrol effects upon Fusarium verticillioides growth and fumonisin B1 production. 2004 Res. Microbiol. pmid:15501652
Cavaglieri L et al. Biocontrol of Bacillus subtilis against Fusarium verticillioides in vitro and at the maize root level. 2005 Jun-Jul Res. Microbiol. pmid:15950130
Kovács M et al. Feed exposure to FB1 can aggravate pneumonic damages in pigs provoked by P. multocida. 2016 Res. Vet. Sci. pmid:27663368
Martins HM et al. Occurrence of fumonisins in feed for swine and horses. 2012 Jul-Sep Rev Iberoam Micol pmid:21907302
del Río García JC et al. [Evaluation of the cytotoxicity of aflatoxin and fumonisin in swine intestinal cells]. 2007 Rev Iberoam Micol pmid:17604433