fumonisin b1

fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.

Cross Reference

Introduction

To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with fumonisin b1?

fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with fumonisin b1

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Inflammation D007249 119 associated lipids
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Esophageal Neoplasms D004938 20 associated lipids
Precancerous Conditions D011230 48 associated lipids
Per page 10 20 50 100 | Total 54

PubChem Associated disorders and diseases

What pathways are associated with fumonisin b1

Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
Loading... please refresh the page if content is not showing up.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with fumonisin b1?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with fumonisin b1?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with fumonisin b1?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with fumonisin b1?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with fumonisin b1?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with fumonisin b1

Download all related citations
Per page 10 20 50 100 | Total 1278
Authors Title Published Journal PubMed Link
Rumora L et al. Cytotoxic and genotoxic effects of fumonisin B1 on rabbit kidney RK13 cell line. 2002 Arch. Toxicol. pmid:11875625
Loiseau N et al. New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver. 2015 Arch. Toxicol. pmid:25155190
Wentzel JF et al. Evaluation of the cytotoxic properties, gene expression profiles and secondary signalling responses of cultured cells exposed to fumonisin B1, deoxynivalenol and zearalenone mycotoxins. 2017 Arch. Toxicol. pmid:27757495
Abado-Becognee K et al. Cytotoxicity of fumonisin B1: implication of lipid peroxidation and inhibition of protein and DNA syntheses. 1998 Arch. Toxicol. pmid:9587019
Klarić MS et al. Cytotoxicity and apoptosis induced by fumonisin B(1), beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment. 2008 Arch. Toxicol. pmid:17879085
Sharma RP et al. Fumonisin hepatotoxicity is reduced in mice carrying the human tumour necrosis factor alpha transgene. 2000 Arch. Toxicol. pmid:10959799
Yin S et al. Fumonisin B1 induces autophagic cell death via activation of ERN1-MAPK8/9/10 pathway in monkey kidney MARC-145 cells. 2016 Arch. Toxicol. pmid:25925693
Dahdouh F et al. Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1. 2014 Arch. Toxicol. pmid:24448832
Mobio TA et al. Prevention by vitamin E of DNA fragmentation and apoptosis induced by fumonisin B1 in C6 glioma cells. 2000 Arch. Toxicol. pmid:10839479
Domijan AM Fumonisin B(1): a neurotoxic mycotoxin. 2012 Arh Hig Rada Toksikol pmid:23334049
Cvetnić Z et al. Toxigenic potential of Fusarium species isolated from non-harvested maize. 2005 Arh Hig Rada Toksikol pmid:16180614
Kovacić S et al. Fumonisin B1 neurotoxicity in young carp (Cyprinus carpio L.). 2009 Arh Hig Rada Toksikol pmid:20061242
Worgall TS et al. Ceramide synthesis correlates with the posttranscriptional regulation of the sterol-regulatory element-binding protein. 2004 Arterioscler. Thromb. Vasc. Biol. pmid:15132973
Alizadeh AM et al. Fumonisin B1 contamination of cereals and risk of esophageal cancer in a high risk area in northeastern Iran. 2012 Asian Pac. J. Cancer Prev. pmid:22938431
Christley RM et al. Leukoencephalomalacia in horses. 1993 Aust. Vet. J. pmid:8216085
Sousa FC et al. Effect of fumonisin-containing diet on the myenteric plexus of the jejunum in rats. 2014 Auton Neurosci pmid:25183308
Deshmukh S et al. Effects of Fusarium moniliforme culture material containing known levels of fumonisin B1 on progress of Salmonella Gallinarum infection in Japanese quail: clinical signs and hematologic studies. 2005 Avian Dis. pmid:16094834
Ledoux DR et al. Individual and combined effects of the Fusarium mycotoxins fumonisin B1 and moniliformin in broiler chicks. 2003 Oct-Dec Avian Dis. pmid:14708984
Bermudez AJ et al. The individual and combined effects of the Fusarium mycotoxins moniliformin and fumonisin B1 in turkeys. 1997 Apr-Jun Avian Dis. pmid:9201392
Espada Y et al. Fumonisin mycotoxicosis in broilers: plasma proteins and coagulation modifications. 1997 Jan-Mar Avian Dis. pmid:9087322
Brown TP et al. Fumonisin mycotoxicosis in broilers: performance and pathology. 1992 Apr-Jun Avian Dis. pmid:1627116
Espada Y et al. Fumonisin mycotoxicosis in broilers. Weights and serum chemistry modifications. 1994 Jul-Sep Avian Dis. pmid:7832697
Grimes JL et al. Paralysis of undetermined origin in bobwhite quail. 1993 Apr-Jun Avian Dis. pmid:8363521
Sharma D et al. Toxic interaction between fumonisin B1 and moniliformin for cardiac lesions in Japanese quail. 2012 Avian Dis. pmid:23050472
Deshmukh S et al. Pathologic changes in extrahepatic organs and agglutinin response to Salmonella Gallinarum infection in Japanese quail fed Fusarium verticillioides culture material containing known levels of fumonisin B1. 2007 Avian Dis. pmid:17992930
Bermudez AJ et al. The chronic effects of Fusarium moniliforme culture material, containing known levels of fumonisin B1, in turkeys. 1996 Jan-Mar Avian Dis. pmid:8713041
Bermudez AJ et al. Effects of Fusarium moniliforme culture material containing known levels of fumonisin B1 in ducklings. 1995 Oct-Dec Avian Dis. pmid:8719224
Deshmukh S et al. Individual and combined effects of Fusarium moniliforme culture material, containing known levels of fumonisin B1, and Salmonella gallinarum infection on liver of Japanese quail. 2005 Avian Dis. pmid:16405006
Klarić MS et al. Lipid peroxidation and glutathione levels in porcine kidney PK15 cells after individual and combined treatment with fumonisin B(1), beauvericin and ochratoxin A. 2007 Basic Clin. Pharmacol. Toxicol. pmid:17309518
Wattenberg EV et al. Activation of mitogen-activated protein kinase by the carcinogenic mycotoxin fumonisin B1. 1996 Biochem. Biophys. Res. Commun. pmid:8878562
Yin JJ et al. Effects of fumonisin B1 on oxygen transport in membranes. 1996 Biochem. Biophys. Res. Commun. pmid:8769126
Jiang L et al. Preferential involvement of both ROS and ceramide in fenretinide-induced apoptosis of HL60 rather than NB4 and U937 cells. 2011 Biochem. Biophys. Res. Commun. pmid:21237137
Akao Y et al. Ceramide accumulation is independent of camptothecin-induced apoptosis in prostate cancer LNCaP cells. 2002 Biochem. Biophys. Res. Commun. pmid:12051721
Rother J et al. Biosynthesis of sphingolipids: dihydroceramide and not sphinganine is desaturated by cultured cells. 1992 Biochem. Biophys. Res. Commun. pmid:1449467
Kobayashi Y et al. The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice. 2012 Biochem. Biophys. Res. Commun. pmid:22503971
Ganguly S et al. Metabolic depletion of sphingolipids enhances the mobility of the human serotonin1A receptor. 2011 Biochem. Biophys. Res. Commun. pmid:21726540
Fukuda H et al. Inhibition of protein serine/threonine phosphatases by fumonisin B1, a mycotoxin. 1996 Biochem. Biophys. Res. Commun. pmid:8602837
Inooka S and Toyokuni T Sphingosine transfer in cell-to-cell interaction. 1996 Biochem. Biophys. Res. Commun. pmid:8579607
Ziulkoski AL et al. De novo synthesis and recycling pathways of sphingomyelin in rat Sertoli cells. 2001 Biochem. Biophys. Res. Commun. pmid:11237757
Bionda C et al. Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria? 2004 Biochem. J. pmid:15144238
Véret J et al. Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells. 2011 Biochem. J. pmid:21592087
Luttgeharm KD et al. Substrate specificity, kinetic properties and inhibition by fumonisin B1 of ceramide synthase isoforms from Arabidopsis. 2016 Biochem. J. pmid:26635357
Gueguen G et al. A lysophosphatidic acid analogue is revealed as a potent inhibitor of phosphatidylcholine synthesis, inducing apoptosis. 2002 Biochem. J. pmid:12197836
Lee JY et al. Cell-cycle-dependent changes in ceramide levels preceding retinoblastoma protein dephosphorylation in G2/M. 1998 Biochem. J. pmid:9716505
Grenier B et al. The low intestinal and hepatic toxicity of hydrolyzed fumonisin B₁ correlates with its inability to alter the metabolism of sphingolipids. 2012 Biochem. Pharmacol. pmid:22366513
Loiseau N et al. Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance. 2007 Biochem. Pharmacol. pmid:17499218
Paila YD et al. Metabolic depletion of sphingolipids impairs ligand binding and signaling of human serotonin1A receptors. 2010 Biochemistry pmid:20170167
Babenko NA and Kharchenko VS Effects of inhibitors of key enzymes of sphingolipid metabolism on insulin-induced glucose uptake and glycogen synthesis in liver cells of old rats. 2015 Biochemistry Mosc. pmid:25754045
Soeda S et al. Daunorubicin attenuates tumor necrosis factor-alpha-induced biosynthesis of plasminogen activator inhibitor-1 in human umbilical vein endothelial cells. 2001 Biochim. Biophys. Acta pmid:11336794
Yin JJ et al. Effects of fumonisin B1 on lipid peroxidation in membranes. 1998 Biochim. Biophys. Acta pmid:9565668
Patwardhan GA et al. Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells. 2014 Biochim. Biophys. Acta pmid:25195822
Badiani K et al. Effect of fumonisin B1 on phosphatidylethanolamine biosynthesis in Chinese hamster ovary cells. 1996 Biochim. Biophys. Acta pmid:8982265
Pelagalli A et al. The mycotoxin fumonisin B1 inhibits integrin-mediated cell-matrix adhesion. 1999 Biochimie pmid:10575354
Benedetti R et al. Degradation of fumonisin B1 by a bacterial strain isolated from soil. 2006 Biodegradation pmid:16453169
Martynova EA et al. [Modulation of the level of sphingomyelin cycle products and expression of the CD3 receptor in immunocompetent organs by fumonisin B1]. 1995 Biokhimiia pmid:7779984
Konoshima T et al. Anti-tumor-promoting activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. (I). 1998 Biol. Pharm. Bull. pmid:9743252
Takasaki M et al. Anti-carcinogenic activity of Taraxacum plant. I. 1999 Biol. Pharm. Bull. pmid:10408234
Martynova EA et al. [TNF-induced apoptosis and necrosis in myeloleukemia cells HL-60 is regulated by reactive oxygen metabolites depending on a cell cycle phase]. 2003 Jan-Feb Biomed Khim pmid:14569872
Min WK et al. Production and characterization of monoclonal antibody and its recombinant single chain variable fragment specific for a food-born mycotoxin, fumonisin B1. 2010 Bioprocess Biosyst Eng pmid:19597742
Fukuda S et al. Preparation and characterization of anti-fumonisin monoclonal antibodies. 1994 Biosci. Biotechnol. Biochem. pmid:7764867
Yamashita A et al. Fusarium mycotoxins (fumonisins, nivalenol, and zearalenone) and aflatoxins in corn from Southeast Asia. 1995 Biosci. Biotechnol. Biochem. pmid:8520126
Li C et al. A universal multi-wavelength fluorescence polarization immunoassay for multiplexed detection of mycotoxins in maize. 2016 Biosens Bioelectron pmid:26720917
Wang C et al. Magneto-controlled aptasensor for simultaneous electrochemical detection of dual mycotoxins in maize using metal sulfide quantum dots coated silica as labels. 2017 Biosens Bioelectron pmid:27816583
Urusov AE et al. High-sensitivity immunochromatographic assay for fumonisin B1 based on indirect antibody labeling. 2017 Biotechnol. Lett. pmid:28150075
Cabrera RM et al. Investigations into the etiology of neural tube defects. 2004 Birth Defects Res. C Embryo Today pmid:15662706
Gelineau-van Waes J et al. Maternal fumonisin exposure and risk for neural tube defects: mechanisms in an in vivo mouse model. 2005 Birth Defects Res. Part A Clin. Mol. Teratol. pmid:15959874
Gelineau-van Waes J et al. Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. 2012 Birth Defects Res. Part A Clin. Mol. Teratol. pmid:22991331
Izquierdo-Useros N et al. Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway. 2009 Blood pmid:18945959
Maschietto V et al. QTL mapping and candidate genes for resistance to Fusarium ear rot and fumonisin contamination in maize. 2017 BMC Plant Biol. pmid:28109190
Kim JE et al. AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast. 2008 Bone pmid:18502715
Marin DE et al. Sex-related differences in the immune response of weanling piglets exposed to low doses of fumonisin extract. 2006 Br. J. Nutr. pmid:16768843
Sanden M et al. Cross-generational feeding of Bt (Bacillus thuringiensis)-maize to zebrafish (Danio rerio) showed no adverse effects on the parental or offspring generations. 2013 Br. J. Nutr. pmid:23768244
Butkeraitis P et al. Effect of dietary fumonisin B1 on laying Japanese quail. 2004 Br. Poult. Sci. pmid:15697020
Prathapkumar SH et al. Disease outbreak in laying hens arising from the consumption of fumonisin-contaminated food. 1997 Br. Poult. Sci. pmid:9510989
Tessari EN et al. Effects of aflatoxin B1 and fumonisin B1 on body weight, antibody titres and histology of broiler chicks. 2006 Br. Poult. Sci. pmid:16787861
Schwarz A and Futerman AH Inhibition of sphingolipid synthesis, but not degradation, alters the rate of dendrite growth in cultured hippocampal neurons. 1998 Brain Res. Dev. Brain Res. pmid:9693790
Miguel Tde Á et al. Effect of fungicide on Fusarium verticillioides mycelial morphology and fumonisin B₁ production. 2015 Braz. J. Microbiol. pmid:26221120
Trigo-Stockli DM et al. Fumonisin B1 levels in 1995 and 1996 Kansas corn. 2002 Bull Environ Contam Toxicol pmid:12068939
Cortez-Rocha MO et al. Effect of extrusion processing on fumonisin B(1) and hydrolyzed fumonisin B(1) in contaminated alkali-cooked corn. 2002 Bull Environ Contam Toxicol pmid:12232716
Beier RC et al. Calculated three dimensional structures of the fumonisin B1-4 mycotoxins. 1995 Bull Environ Contam Toxicol pmid:7767023
Cortez-Rocha MO et al. Occurrence of fumonisin B1 and hydrolyzed fumonisin B1 in Mexican nixtamalized cornmeal. 2005 Bull Environ Contam Toxicol pmid:15768501
Pósa R et al. Interaction of Bordetella bronchiseptica, Pasteurella multocida, and fumonisin B1 in the porcine respiratory tract as studied by computed tomography. 2011 Can. J. Vet. Res. pmid:22210993
Park MA et al. Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation. 2008 Cancer Biol. Ther. pmid:18787411
Abnet CC et al. Sphingolipids as biomarkers of fumonisin exposure and risk of esophageal squamous cell carcinoma in china. 2001 Cancer Causes Control pmid:11714110
Voss KA et al. Carcinogenicity and mechanism of action of fumonisin B1: a mycotoxin produced by Fusarium moniliforme (= F. verticillioides). 2002 Cancer Detect. Prev. pmid:12088196
van der Westhuizen L et al. Fumonisin B1 as a urinary biomarker of exposure in a maize intervention study among South African subsistence farmers. 2011 Cancer Epidemiol. Biomarkers Prev. pmid:21266524
Gong YY et al. Association between tortilla consumption and human urinary fumonisin B1 levels in a Mexican population. 2008 Cancer Epidemiol. Biomarkers Prev. pmid:18349288
Gelderblom WC et al. Cancer initiation by fumonisin B(1) in rat liver--role of cell proliferation. 2001 Cancer Lett. pmid:11431101
Gelderblom WC et al. The cancer-promoting potential of fumonisin B1 in rat liver using diethylnitrosamine as a cancer initiator. 1996 Cancer Lett. pmid:9020908
Sahu SC et al. Peroxidation of membrane lipids and oxidative DNA damage by fumonisin B1 in isolated rat liver nuclei. 1998 Cancer Lett. pmid:9566705
Lemmer ER et al. The effects of dietary iron overload on fumonisin B1-induced cancer promotion in the rat liver. 1999 Cancer Lett. pmid:10656628
Takasaki M et al. Cancer chemopreventive activity of euglobal-G1 from leaves of Eucalyptus grandis. 2000 Cancer Lett. pmid:10814880
Mehta R et al. Glutathione S-transferase-placental form expression and proliferation of hepatocytes in fumonisin B1-treated male and female Sprague-Dawley rats. 1998 Cancer Lett. pmid:9652790
Blázquez C et al. Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. 2004 Cancer Res. pmid:15313899
Wang XZ et al. Aberrant sphingolipid signaling is involved in the resistance of prostate cancer cell lines to chemotherapy. 1999 Cancer Res. pmid:10582708
Huang C et al. Repression of protein kinase C and stimulation of cyclic AMP response elements by fumonisin, a fungal encoded toxin which is a carcinogen. 1995 Cancer Res. pmid:7712470
Garzotto M et al. 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase. 1998 Cancer Res. pmid:9605775
Blázquez C et al. Cannabinoids inhibit glioma cell invasion by down-regulating matrix metalloproteinase-2 expression. 2008 Cancer Res. pmid:18339876
Abdel Nour AM et al. Folate receptor and human reduced folate carrier expression in HepG2 cell line exposed to fumonisin B1 and folate deficiency. 2007 Carcinogenesis pmid:17615259
Ramljak D et al. A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity. 2000 Carcinogenesis pmid:10910956