| MeSH term | MeSH ID | Detail |
|---|---|---|
| Stomach Ulcer | D013276 | 75 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Kidney Neoplasms | D007680 | 29 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Fatty Liver | D005234 | 48 associated lipids |
| Body Weight | D001835 | 333 associated lipids |
| Esophageal Neoplasms | D004938 | 20 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
fumonisin b1
fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.
Cross Reference
Introduction
To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with fumonisin b1?
fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- Am. J. Physiol. Heart Circ. Physiol. (1)
- Am. J. Physiol. Regul. Integr. Comp. Physiol. (1)
- Cancer Res. (1)
- Others (5)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with fumonisin b1
PubChem Associated disorders and diseases
What pathways are associated with fumonisin b1
Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with fumonisin b1?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with fumonisin b1?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with fumonisin b1?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with fumonisin b1?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with fumonisin b1?
There are no associated biomedical information in the current reference collection.
NCBI Entrez Crosslinks
All references with fumonisin b1
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gelderblom WC et al. | Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. | 1991 | Carcinogenesis | pmid:1649015 |
| Gelderblom WC et al. | The cancer-initiating potential of the fumonisin B mycotoxins. | 1992 | Carcinogenesis | pmid:1547534 |
| Lemmer ER et al. | Fumonisin B1-induced hepatocellular and cholangiocellular tumors in male Fischer 344 rats: potentiating effects of 2-acetylaminofluorene on oval cell proliferation and neoplastic development in a discontinued feeding study. | 2004 | Carcinogenesis | pmid:14988222 |
| Lemmer ER et al. | Histopathology and gene expression changes in rat liver during feeding of fumonisin B1, a carcinogenic mycotoxin produced by Fusarium moniliforme. | 1999 | Carcinogenesis | pmid:10334199 |
| Gelderblom WC et al. | Fumonisin B1 dosimetry in relation to cancer initiation in rat liver. | 1994 | Carcinogenesis | pmid:8313510 |
| Pinelli E et al. | Activation of mitogen-activated protein kinase by fumonisin B(1) stimulates cPLA(2) phosphorylation, the arachidonic acid cascade and cAMP production. | 1999 | Carcinogenesis | pmid:10469611 |
| Tolleson WH et al. | Apoptotic and anti-proliferative effects of fumonisin B1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells. | 1996 | Carcinogenesis | pmid:8625445 |
| Gopee NV and Sharma RP | The mycotoxin fumonisin B1 transiently activates nuclear factor-kappaB, tumor necrosis factor alpha and caspase 3 via protein kinase Calpha-dependent pathway in porcine renal epithelial cells. | 2004 | Cell Biol. Toxicol. | pmid:15499968 |
| Lang KS et al. | Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. | 2004 | Cell Death Differ. | pmid:14615798 |
| Appierto V et al. | Involvement of c-Fos in fenretinide-induced apoptosis in human ovarian carcinoma cells. | 2004 | Cell Death Differ. | pmid:14647238 |
| Miguet C et al. | Ceramide generation occurring during 7beta-hydroxycholesterol- and 7-ketocholesterol-induced apoptosis is caspase independent and is not required to trigger cell death. | 2001 | Cell Death Differ. | pmid:11313706 |
| Ciarlo L et al. | Association of fission proteins with mitochondrial raft-like domains. | 2010 | Cell Death Differ. | pmid:20075943 |
| Gamen S et al. | Caspases are the main executioners of Fas-mediated apoptosis, irrespective of the ceramide signalling pathway. | 1998 | Cell Death Differ. | pmid:10200470 |
| Spinedi A et al. | Ceramide accumulation precedes caspase-dependent apoptosis in CHP-100 neuroepithelioma cells exposed to the protein phosphatase inhibitor okadaic acid. | 1999 | Cell Death Differ. | pmid:10453072 |
| Aflaki E et al. | C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. | 2012 | Cell Death Dis | pmid:22419109 |
| Shi L et al. | Involvement of sphingoid bases in mediating reactive oxygen intermediate production and programmed cell death in Arabidopsis. | 2007 | Cell Res. | pmid:18059378 |
| Schilling T and Eder C | Importance of lipid rafts for lysophosphatidylcholine-induced caspase-1 activation and reactive oxygen species generation. | 2010 | Cell. Immunol. | pmid:20832779 |
| Yi F et al. | Mechanism of homocysteine-induced Rac1/NADPH oxidase activation in mesangial cells: role of guanine nucleotide exchange factor Vav2. | 2007 | Cell. Physiol. Biochem. | pmid:17982273 |
| Inooka S and Toyokuni T | Use of fumonisin B1 to test the intercellular transfer of sphingosine. | 1996 | Cell. Signal. | pmid:8958448 |
| Gopee NV et al. | Fumonisin B1-induced apoptosis is associated with delayed inhibition of protein kinase C, nuclear factor-kappaB and tumor necrosis factor alpha in LLC-PK1 cells. | 2003 | Chem. Biol. Interact. | pmid:14597127 |
| Bhandari N et al. | Modulation of selected cell signaling genes in mouse liver by fumonisin B1. | 2002 | Chem. Biol. Interact. | pmid:11879819 |
| Tran ST et al. | Sphinganine to sphingosine ratio and predictive biochemical markers of fumonisin B1 exposure in ducks. | 2003 | Chem. Biol. Interact. | pmid:12902153 |
| Tardieu D et al. | Tissue persistence of fumonisin B1 in ducks and after exposure to a diet containing the maximum European tolerance for fumonisins in avian feeds. | 2009 | Chem. Biol. Interact. | pmid:19559689 |
| Orsi RB et al. | Acute toxicity of a single gavage dose of fumonisin B1 in rabbits. | 2009 | Chem. Biol. Interact. | pmid:19330885 |
| Johnson VJ et al. | Increased susceptibility of renal epithelial cells to TNFalpha-induced apoptosis following treatment with fumonisin B1. | 2003 | Chem. Biol. Interact. | pmid:12732456 |
| Orsi RB et al. | Effects of oral administration of aflatoxin B1 and fumonisin B1 in rabbits (Oryctolagus cuniculus). | 2007 | Chem. Biol. Interact. | pmid:17888418 |
| Dilkin P et al. | Toxicokinetics and toxicological effects of single oral dose of fumonisin B1 containing Fusarium verticillioides culture material in weaned piglets. | 2010 | Chem. Biol. Interact. | pmid:20338158 |
| Sharma N et al. | Sphingosine kinase activity confers resistance to apoptosis by fumonisin B1 in human embryonic kidney (HEK-293) cells. | 2004 | Chem. Biol. Interact. | pmid:15607760 |
| Tardieu D et al. | Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16412405 |
| Tran ST et al. | Serum sphinganine and the sphinganine to sphingosine ratio as a biomarker of dietary fumonisins during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16413517 |
| Lemke SL et al. | Deamination of fumonisin B(1) and biological assessment of reaction product toxicity. | 2001 | Chem. Res. Toxicol. | pmid:11170503 |
| Nácher-Mestre J et al. | Occurrence and potential transfer of mycotoxins in gilthead sea bream and Atlantic salmon by use of novel alternative feed ingredients. | 2015 | Chemosphere | pmid:25754010 |
| Kawano Y et al. | Regulation of interleukin-1alpha and tumor necrosis factor-alpha-induced interleukin-8 production by amnion-derived (WISH) cells. | 2012 | Clin Exp Obstet Gynecol | pmid:22675954 |
| Theumer MG et al. | Immunobiological effects of fumonisin B1 in experimental subchronic mycotoxicoses in rats. | 2002 | Clin. Diagn. Lab. Immunol. | pmid:11777845 |
| Zadeh MH and Shahdadi H | Nanocellulose coated with various free fatty acids can adsorb fumonisin B1, and decrease its toxicity. | 2015 | Colloids Surf B Biointerfaces | pmid:26142625 |
| Jebali A et al. | Modification of nanocellulose by poly-lysine can inhibit the effect of fumonisin B1 on mouse liver cells. | 2015 | Colloids Surf B Biointerfaces | pmid:25601749 |
| Daković A et al. | Influence of natural zeolitic tuff and organozeolites surface charge on sorption of ionizable fumonisin B(1). | 2010 | Colloids Surf B Biointerfaces | pmid:20004084 |
| Theumer MG et al. | The lipid-mediated hypothesis of fumonisin B1 toxicodynamics tested in model membranes. | 2008 | Colloids Surf B Biointerfaces | pmid:18296035 |
| Bhandari N et al. | Temporal expression of fumonisin B(1)-induced tumor necrosis factor-alpha and interferon gamma in mice. | 2002 | Comp. Biochem. Physiol. C Toxicol. Pharmacol. | pmid:11879779 |
| Tsunoda M et al. | Fumonisin B1-induced increases in neurotransmitter metabolite levels in different brain regions of BALB/c mice. | 1998 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:9827064 |
| Hu J et al. | Inhibition of Fusarium solani Infection in Murine Keratocytes by Lactobacillus salivarius ssp. salivarius JCM1231 Culture Filtrate In Vitro. | 2017 | Curr. Eye Res. | pmid:28636459 |
| Sharma RP et al. | Increased expression of CD95-ligand and other apoptotic signaling factors by fumonisin B1, a hepatotoxic mycotoxin, in livers of mice lacking tumor necrosis factor alpha. | 2003 | Cytokine | pmid:14596819 |
| Sharma RP et al. | Mice lacking both TNFalpha receptors show increased constitutive expression of IFNgamma: a possible reason for lack of protection from fumonisin B1 hepatotoxicity. | 2006 | Cytokine | pmid:16884913 |
| Maedler K et al. | Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. | 2003 | Diabetes | pmid:12606514 |
| Nakashita M et al. | Attenuation of acetic acid-induced gastric ulcer formation in rats by glucosylceramide synthase inhibitors. | 2013 | Dig. Dis. Sci. | pmid:22918683 |
| Kim B et al. | Cytotoxicity of fumonisin B(1) in spheroid and monolayer cultures of rat hepatocytes. | 2008 | Drug Chem Toxicol | pmid:18622869 |
| Petrinec Z et al. | Fumonisin B1 causes multiple lesions in common carp (Cyprinus carpio). | 2004 | DTW. Dtsch. Tierarztl. Wochenschr. | pmid:15503536 |
| Shaheen HM et al. | The ceramide inhibitor fumonisin B1 mitigates the pulmonary effects of low-dose diesel exhaust inhalation in mice. | 2016 | Ecotoxicol. Environ. Saf. | pmid:27376354 |
| Akiyama H et al. | [Comparison of several fluorescence HPLC methods for fumonisin analysis]. | 1994 | Eisei Shikenjo Hokoku | pmid:8854911 |
| Jaffrézou JP et al. | Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis. | 1996 | EMBO J. | pmid:8665849 |
| Witty JP et al. | Induction of apoptotic cell death in hen granulosa cells by ceramide. | 1996 | Endocrinology | pmid:8940345 |
| Njumbe Ediage E et al. | Multimycotoxin analysis in urines to assess infant exposure: a case study in Cameroon. | 2013 | Environ Int | pmid:23669720 |
| Mayer S et al. | Occupational exposure to mould and microbial metabolites during onion sorting--insights into an overlooked workplace. | 2016 | Environ Monit Assess | pmid:26863887 |
| Riley RT et al. | Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. | 2001 | Environ. Health Perspect. | pmid:11359699 |
| Chelule PK et al. | Exposure of rural and urban populations in KwaZulu Natal, South Africa, to fumonisin B(1) in maize. | 2001 | Environ. Health Perspect. | pmid:11333186 |
| Proceedings of the International Conference on the Toxicology of Fumonisin. 28-30 June 1999, Arlington, Virginia. | 2001 | Environ. Health Perspect. | pmid:11359690 | |
| Marasas WF | Discovery and occurrence of the fumonisins: a historical perspective. | 2001 | Environ. Health Perspect. | pmid:11359691 |
| ApSimon JW | Structure, synthesis, and biosynthesis of fumonisin B1 and related compounds. | 2001 | Environ. Health Perspect. | pmid:11359692 |
| Haschek WM et al. | Fumonisin toxicosis in swine: an overview of porcine pulmonary edema and current perspectives. | 2001 | Environ. Health Perspect. | pmid:11359693 |
| Voss KA et al. | An overview of rodent toxicities: liver and kidney effects of fumonisins and Fusarium moniliforme. | 2001 | Environ. Health Perspect. | pmid:11359694 |
| Gelderblom WC et al. | Toxicity of culture material of Fusarium verticillioides strain MRC 826 to nonhuman primates. | 2001 | Environ. Health Perspect. | pmid:11359695 |
| Howard PC et al. | Fumonisin b1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F1 mice. | 2001 | Environ. Health Perspect. | pmid:11359696 |
| Merrill AH et al. | Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. | 2001 | Environ. Health Perspect. | pmid:11359697 |
| Gelderblom WC et al. | Fumonisin-induced hepatocarcinogenesis: mechanisms related to cancer initiation and promotion. | 2001 | Environ. Health Perspect. | pmid:11359698 |
| Howard PC et al. | Compensatory regeneration as a mechanism for renal tubule carcinogenesis of fumonisin B1 in the F344/N/Nctr BR rat. | 2001 | Environ. Health Perspect. | pmid:11359700 |
| Jones C et al. | Analysis of fumonisin B1-induced apoptosis. | 2001 | Environ. Health Perspect. | pmid:11359701 |
| Miller JD | Factors that affect the occurrence of fumonisin. | 2001 | Environ. Health Perspect. | pmid:11359702 |
| Bacon CW et al. | Biological control of Fusarium moniliforme in maize. | 2001 | Environ. Health Perspect. | pmid:11359703 |
| Saunders DS et al. | Control of fumonisin: effects of processing. | 2001 | Environ. Health Perspect. | pmid:11359704 |
| Duvick J | Prospects for reducing fumonisin contamination of maize through genetic modification. | 2001 | Environ. Health Perspect. | pmid:11359705 |
| Myburg RB et al. | Cytotoxicity of fumonisin B1, diethylnitrosamine, and catechol on the SNO esophageal cancer cell line. | 2002 | Environ. Health Perspect. | pmid:12153764 |
| Shirima CP et al. | A prospective study of growth and biomarkers of exposure to aflatoxin and fumonisin during early childhood in Tanzania. | 2015 | Environ. Health Perspect. | pmid:25325363 |
| Ridenour JB et al. | UBL1 of Fusarium verticillioides links the N-end rule pathway to extracellular sensing and plant pathogenesis. | 2014 | Environ. Microbiol. | pmid:24237664 |
| Mary VS et al. | The aflatoxin B -fumonisin B toxicity in BRL-3A hepatocytes is associated to induction of cytochrome P450 activity and arachidonic acid metabolism. | 2017 | Environ. Toxicol. | pmid:28181396 |
| Bezuidenhout CC et al. | Multiplex PCR-based detection of potential fumonisin-producing Fusarium in traditional African vegetables. | 2006 | Environ. Toxicol. | pmid:16841320 |
| Goldfinger M et al. | Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling. | 2011 | Eur. J. Immunol. | pmid:21268018 |
| Sjögren B et al. | Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. | 2006 | Eur. J. Pharmacol. | pmid:17064686 |
| Wispriyono B et al. | A role for the de novo sphingolipids in apoptosis of photosensitized cells. | 2002 | Exp. Cell Res. | pmid:12213223 |
| Suzuki A et al. | Sequential operation of ceramide synthesis and ICE cascade in CPT-11-initiated apoptotic death signaling. | 1997 | Exp. Cell Res. | pmid:9184074 |
| Itakura A et al. | Ceramide and sphingosine rapidly induce apoptosis of murine mast cells supported by interleukin-3 and stem cell factor. | 2002 | Exp. Hematol. | pmid:11882365 |
| Isogai C et al. | Analysis of bax protein in sphingosine-induced apoptosis in the human leukemic cell line TF1 and its bcl-2 transfectants. | 1998 | Exp. Hematol. | pmid:9808050 |
| Nadjia B and Fatima LD | Beneficial effects of Androctonus australis hector venom and its non-toxic fraction in the restoration of early hepatocyte-carcinogenesis induced by FB1 mycotoxin: Involvement of oxidative biomarkers. | 2015 | Exp. Mol. Pathol. | pmid:26142225 |
| Stoev SD et al. | Experimental mycotoxic nephropathy in pigs provoked by a mouldy diet containing ochratoxin A and fumonisin B1. | 2012 | Exp. Toxicol. Pathol. | pmid:21296565 |
| Lei M et al. | In vitro investigation of individual and combined cytotoxic effects of aflatoxin B1 and other selected mycotoxins on the cell line porcine kidney 15. | 2013 | Exp. Toxicol. Pathol. | pmid:23809186 |
| Liu YY et al. | A role for ceramide in driving cancer cell resistance to doxorubicin. | 2008 | FASEB J. | pmid:18245173 |
| Granata R et al. | Dual effects of IGFBP-3 on endothelial cell apoptosis and survival: involvement of the sphingolipid signaling pathways. | 2004 | FASEB J. | pmid:15247143 |
| Bezombes C et al. | Lysosomal sphingomyelinase is not solicited for apoptosis signaling. | 2001 | FASEB J. | pmid:11156942 |
| Zhao H et al. | Anoxia and reoxygenation of human endothelial cells decrease ceramide glucosyltransferase expression and activates caspases. | 2003 | FASEB J. | pmid:12586734 |
| Norholm MH et al. | Expression of the Arabidopsis high-affinity hexose transporter STP13 correlates with programmed cell death. | 2006 | FEBS Lett. | pmid:16616142 |
| Xing F et al. | Reactive oxygen species promote chloroplast dysfunction and salicylic acid accumulation in fumonisin B1-induced cell death. | 2013 | FEBS Lett. | pmid:23711368 |
| Kutuzov MA et al. | Expression and characterization of PP7, a novel plant protein Ser/Thr phosphatase distantly related to RdgC/PPEF and PP5. | 1998 | FEBS Lett. | pmid:9862444 |
| Shim WB and Woloshuk CP | Nitrogen repression of fumonisin B1 biosynthesis in Gibberella fujikuroi. | 1999 | FEMS Microbiol. Lett. | pmid:10436928 |
| Bottalico A et al. | Beauvericin and fumonisin B1 in preharvest Fusarium moniliforme maize ear rot in Sardinia. | 1995 Jul-Aug | Food Addit Contam | pmid:7589723 |
| Cirillo T et al. | Natural co-occurrence of deoxynivalenol and fumonisins B1 and B2 in Italian marketed foodstuffs. | 2003 | Food Addit Contam | pmid:12881130 |
| Scott PM and Lawrence GA | Determination of hydrolysed fumonisin B1 in alkali-processed corn foods. | 1996 | Food Addit Contam | pmid:8885322 |
| Scudamore KA et al. | Determination of mycotoxins in pet foods sold for domestic pets and wild birds using linked-column immunoassay clean-up and HPLC. | 1997 Feb-Mar | Food Addit Contam | pmid:9102350 |
| Kim EK et al. | Survey for fumonisin B1 in Korean corn-based food products. | 2002 | Food Addit Contam | pmid:12028644 |
| Broggi LE et al. | Distribution of fumonisins in dry-milled corn fractions in Argentina. | 2002 | Food Addit Contam | pmid:12028645 |
| MarÃn S et al. | Control of growth and fumonisin B1 production by Fusarium verticillioides and Fusarium proliferatum isolates in moist maize with propionate preservatives. | 1999 | Food Addit Contam | pmid:10789377 |
| Preis RA and Vargas EA | A method for determining fumonisin B1 in corn using immunoaffinity column clean-up and thin layer chromatography/densitometry. | 2000 | Food Addit Contam | pmid:10932789 |