fumonisin b1

fumonisin b1 is a lipid of Sphingolipids (SP) class. Fumonisin b1 is associated with abnormalities such as Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL and Malnutrition. The involved functions are known as Gene Expression, Anabolism, Signal, Biosynthetic Pathways and Regulation. Fumonisin b1 often locates in Body tissue, Microsomes, microsomal membrane, Protoplasm and Mitochondria. The associated genes with fumonisin b1 are Genome, P4HTM gene, FATE1 gene, BCL2 gene and TMEM132D gene. The related lipids are dihydroceramide, ceramide 1-phosphate, Sphingolipids, Fatty Acids and Palmitates.

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Introduction

To understand associated biological information of fumonisin b1, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with fumonisin b1?

fumonisin b1 is suspected in Infection, Kidney Diseases, Liver diseases, DERMATITIS HERPETIFORMIS, FAMILIAL, Malnutrition, Celiac Disease and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with fumonisin b1

MeSH term MeSH ID Detail
Stomach Ulcer D013276 75 associated lipids
Adenocarcinoma D000230 166 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Kidney Neoplasms D007680 29 associated lipids
Inflammation D007249 119 associated lipids
Fatty Liver D005234 48 associated lipids
Body Weight D001835 333 associated lipids
Esophageal Neoplasms D004938 20 associated lipids
Precancerous Conditions D011230 48 associated lipids
Per page 10 20 50 100 | Total 54

PubChem Associated disorders and diseases

What pathways are associated with fumonisin b1

Lipid pathways are not clear in current pathway databases. We organized associated pathways with fumonisin b1 through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

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What cellular locations are associated with fumonisin b1?

Related references are published most in these journals:

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What functions are associated with fumonisin b1?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with fumonisin b1?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with fumonisin b1?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with fumonisin b1?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with fumonisin b1

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Authors Title Published Journal PubMed Link
Guzman RE et al. Chronic consumption of fumonisins derived from Fusarium moniliforme culture material: clinical and pathologic effects in swine. 1997 J. Vet. Diagn. Invest. pmid:9211249
Wilson TM et al. Fumonisin B1 levels associated with an epizootic of equine leukoencephalomalacia. 1990 J. Vet. Diagn. Invest. pmid:2094447
Harrison LR et al. Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. 1990 J. Vet. Diagn. Invest. pmid:2094448
Wilson TM et al. A mycological evaluation and in vivo toxicity evaluation of feed from 41 farms with equine leukoencephalomalacia. 1990 J. Vet. Diagn. Invest. pmid:2095286
Osweiler GD et al. Characterization of an epizootic of pulmonary edema in swine associated with fumonisin in corn screenings. 1992 J. Vet. Diagn. Invest. pmid:1554770
Plattner RD et al. Analysis of corn and cultured corn for fumonisin B1 by HPLC and GC/MS by four laboratories. 1991 J. Vet. Diagn. Invest. pmid:1760472
Rottinghaus GE et al. A rapid, sensitive thin layer chromatography procedure for the detection of fumonisin B1 and B2. 1992 J. Vet. Diagn. Invest. pmid:1515494
Ledoux DR et al. Fumonisin toxicity in broiler chicks. 1992 J. Vet. Diagn. Invest. pmid:1515495
Brown DW et al. Experimental feeding of Fusarium moniliforme culture material containing fumonisin B1 to channel catfish, Ictalurus punctatus. 1994 J. Vet. Diagn. Invest. pmid:8011771
Hall JO et al. Serum vitamin A (retinol) reduction in broiler chicks on feed amended with Fusarium proliferatum culture material or fumonisin B1 and moniliformin. 1995 J. Vet. Diagn. Invest. pmid:7578467
Baker DC and Rottinghaus GE Chronic experimental fumonisin intoxication of calves. 1999 J. Vet. Diagn. Invest. pmid:10353364
Casteel SW et al. Chronic toxicity of fumonisin in weanling pigs. 1993 J. Vet. Diagn. Invest. pmid:8373857
Hsiao SH et al. Use of formalin-fixed tissues to determine fumonisin B1-induced sphingolipid alterations in swine. 2007 J. Vet. Diagn. Invest. pmid:17609357
Javed T et al. Serohematologic alterations in broiler chicks on feed amended with Fusarium proliferatum culture material on fumonisin B1 and moniliformin. 1995 J. Vet. Diagn. Invest. pmid:8580176
Colvin BM et al. Fumonisin toxicosis in swine: clinical and pathologic findings. 1993 J. Vet. Diagn. Invest. pmid:8507702
Ross PF et al. Experimental equine leukoencephalomalacia, toxic hepatosis, and encephalopathy caused by corn naturally contaminated with fumonisins. 1993 J. Vet. Diagn. Invest. pmid:8466984
Weibking TS et al. Fumonisin toxicity in turkey poults. 1993 J. Vet. Diagn. Invest. pmid:8466985
Foreman JH et al. Neurologic abnormalities and cerebrospinal fluid changes in horses administered fumonisin B1 intravenously. 2004 Mar-Apr J. Vet. Intern. Med. pmid:15058775
Plumlee KH and Galey FD Neurotoxic mycotoxins: a review of fungal toxins that cause neurological disease in large animals. 1994 Jan-Feb J. Vet. Intern. Med. pmid:8176663
Zomborszky-Kovács M et al. Effects of prolonged exposure to low-dose fumonisin B1 in pigs. 2002 J. Vet. Med. B Infect. Dis. Vet. Public Health pmid:12069274
Zomborszky MK et al. Experiment to determine limits of tolerance for fumonisin B1 in weaned piglets. 2000 J. Vet. Med. B Infect. Dis. Vet. Public Health pmid:10861196
Sozmen M et al. Protective effects of silymarin on fumonisin B₁-induced hepatotoxicity in mice. 2014 J. Vet. Sci. pmid:24136215
Yi F et al. Homocysteine activates NADH/NADPH oxidase through ceramide-stimulated Rac GTPase activity in rat mesangial cells. 2004 Kidney Int. pmid:15496169
Ueda N et al. Role of enhanced ceramide generation in DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells. 1998 Kidney Int. pmid:9690206
Itoh Y et al. Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury. 2006 Kidney Int. pmid:16408118
León-S FE et al. Mycotoxins in myelopathies of man. 1996 Lancet pmid:8855894
Melcion D et al. Study of the biosynthesis of fumonisins B1, B2 and B3 by different strains of Fusarium moniliforme. 1997 Lett. Appl. Microbiol. pmid:9134779
Hu LB et al. Inhibition of fengycins on the production of fumonisin B1 from Fusarium verticillioides. 2009 Lett. Appl. Microbiol. pmid:19018959
Dissanayake ML et al. Fumonisin B(1) production by Fusarium proliferatum strains isolated from Allium fistulosum plants and seeds in Japan. 2009 Lett. Appl. Microbiol. pmid:19416462
Chatterjee D et al. Nuclear disintegration in chicken peritoneal macrophages exposed to fumonisin B1 from Indian maize. 1995 Lett. Appl. Microbiol. pmid:7766078
Cahagnier B et al. Growth of Fusarium moniliforme and its biosynthesis of fumonisin B1 on maize grain as a function of different water activities. 1995 Lett. Appl. Microbiol. pmid:7766121
Cavaglieri L et al. In vitro influence of bacterial mixtures on Fusarium verticillioides growth and fumonisin B1 production: effect of seeds treatment on maize root colonization. 2005 Lett. Appl. Microbiol. pmid:16238641
Marin S et al. Effect of water activity and temperature on growth and fumonisin B1 and B2 production by Fusarium proliferatum and F. moniliforme on maize grain. 1995 Lett. Appl. Microbiol. pmid:7576524
He Q et al. Fumonisin B(1) alters sphingolipid metabolism and tumor necrosis factor alpha expression in heart and lung of mice. 2002 Life Sci. pmid:12175895
Gopee NV and Sharma RP Selective and transient activation of protein kinase C alpha by fumonisin B1, a ceramide synthase inhibitor mycotoxin, in cultured porcine renal cells. 2004 Life Sci. pmid:14729403
Meli R et al. Effect of fumonisin B1 on inducible nitric oxide synthase and cyclooxygenase-2 in LPS-stimulated J774A.1 cells. 2000 Life Sci. pmid:11105999
Kaneshiro T et al. 2-Hydroxyhexadecanoic and 8,9,13-trihydroxydocosanoic acid accumulation by yeasts treated with fumonisin B1. 1993 Lipids pmid:8316046
Gelderblom WC et al. Lipids and delta6-desaturase activity alterations in rat liver microsomal membranes induced by fumonisin B1. 2002 Lipids pmid:12458622
Alessenko AV and Khrenov AV Role of sphingosine in induced apoptosis. 1999 Lipids pmid:10419095
Burger HM et al. Altered lipid parameters in hepatic subcellular membrane fractions induced by fumonisin B1. 2007 Lipids pmid:17393230
Andersen AJC et al. HPLC-HRMS Quantification of the Ichthyotoxin Karmitoxin from Karlodinium armiger. 2017 Mar Drugs pmid:28858210
Xiao-Yun X et al. Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells. 2009 Med. Sci. Monit. pmid:19721393
Auzenne E et al. Cytotoxic effects of sphingolipids as single or multi-modality agents on human melanoma and soft tissue sarcoma in vitro. 1998 Melanoma Res. pmid:9664144
Riley RT and Plattner RD Fermentation, partial purification, and use of serine palmitoyltransferase inhibitors from Isaria (= Cordyceps) sinclairii. 2000 Meth. Enzymol. pmid:10563339
Taitt CR et al. Surface modification and biomolecule immobilization on polymer spheres for biosensing applications. 2011 Methods Mol. Biol. pmid:21424444
Muscarella M et al. Determination of fumonisins B₁ and B₂ in maize food products by a new analytical method based on high-performance liquid chromatography and fluorimetric detection with post-column derivatization. 2011 Methods Mol. Biol. pmid:21567328
Eppley RM Preparatory isolation of mycotoxins from solid phase fungal cultures. 2001 Methods Mol. Biol. pmid:11050990
Wilkes JG and Lay JO Electrospray mass spectrometry for mycotoxin detection and purity analysis. 2001 Methods Mol. Biol. pmid:11050992
Shephard GS Liquid chromatographic method for fumonisins in corn. 2001 Methods Mol. Biol. pmid:11051000
Hartinger D et al. Enhancement of solubility in Escherichia coli and purification of an aminotransferase from Sphingopyxis sp. MTA144 for deamination of hydrolyzed fumonisin B(1). 2010 Microb. Cell Fact. pmid:20718948
Kubo T et al. Chlamydia trachomatis serovar L2 infection model using human lymphoid Jurkat cells. 2012 Microb. Pathog. pmid:22516802
Shimamoto S et al. Changes in ganglioside content affect the binding of Clostridium perfringens epsilon-toxin to detergent-resistant membranes of Madin-Darby canine kidney cells. 2005 Microbiol. Immunol. pmid:15781998
Kim H et al. HXK1 regulates carbon catabolism, sporulation, fumonisin B₁ production and pathogenesis in Fusarium verticillioides. 2011 Microbiology (Reading, Engl.) pmid:21719539
Choi YE and Shim WB Functional characterization of Fusarium verticillioides CPP1, a gene encoding a putative protein phosphatase 2A catalytic subunit. 2008 Microbiology (Reading, Engl.) pmid:18174151
Wang SK et al. Effect of fumonisin B₁ on the cell cycle of normal human liver cells. 2013 Mol Med Rep pmid:23625282
Voss KA et al. Fumonisin B₁ induced neural tube defects were not increased in LM/Bc mice fed folate-deficient diet. 2014 Mol Nutr Food Res pmid:24585430
Torres O et al. Urinary fumonisin B1 and estimated fumonisin intake in women from high- and low-exposure communities in Guatemala. 2014 Mol Nutr Food Res pmid:24375966
Voss KA et al. Extrusion cooking with glucose supplementation of fumonisin-contaminated corn grits protects against nephrotoxicity and disrupted sphingolipid metabolism in rats. 2011 Mol Nutr Food Res pmid:21648070
Riley RT et al. The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets. 2012 Mol Nutr Food Res pmid:22815244
Seiferlein M et al. Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites. 2007 Mol Nutr Food Res pmid:17729221
Pellanda H et al. Fumonisin FB1 treatment acts synergistically with methyl donor deficiency during rat pregnancy to produce alterations of H3- and H4-histone methylation patterns in fetuses. 2012 Mol Nutr Food Res pmid:22707272
Harrer H et al. Identification of N-acyl-fumonisin B1 as new cytotoxic metabolites of fumonisin mycotoxins. 2013 Mol Nutr Food Res pmid:23281112
Marin DE et al. Fumonisin B1 alters cell cycle progression and interleukin-2 synthesis in swine peripheral blood mononuclear cells. 2007 Mol Nutr Food Res pmid:17918165
Shirima CP et al. Dietary exposure to aflatoxin and fumonisin among Tanzanian children as determined using biomarkers of exposure. 2013 Mol Nutr Food Res pmid:23776058
Bouhet S and Oswald IP The intestine as a possible target for fumonisin toxicity. 2007 Mol Nutr Food Res pmid:17642075
Domijan AM et al. The involvement of oxidative stress in ochratoxin A and fumonisin B1 toxicity in rats. 2007 Mol Nutr Food Res pmid:17688296
Riley RT et al. Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. 2015 Mol Nutr Food Res pmid:26264677
Gerding J et al. Determination of mycotoxin exposure in Germany using an LC-MS/MS multibiomarker approach. 2014 Mol Nutr Food Res pmid:25243722
Li J et al. Kunitz trypsin inhibitor: an antagonist of cell death triggered by phytopathogens and fumonisin b1 in Arabidopsis. 2008 Mol Plant pmid:19825555
Figueiredo JM et al. Molecular and functional characterization of the ceramide synthase from Trypanosoma cruzi. 2012 Mar-Apr Mol. Biochem. Parasitol. pmid:22226824
Sandvig K et al. Importance of glycolipid synthesis for butyric acid-induced sensitization to shiga toxin and intracellular sorting of toxin in A431 cells. 1996 Mol. Biol. Cell pmid:8885234
Van IJzendoorn SC et al. Polarized membrane traffic and cell polarity development is dependent on dihydroceramide synthase-regulated sphinganine turnover. 2004 Mol. Biol. Cell pmid:15229289
Schorling S et al. Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. 2001 Mol. Biol. Cell pmid:11694577
Lipardi C et al. Detergent-insoluble GPI-anchored proteins are apically sorted in fischer rat thyroid cells, but interference with cholesterol or sphingolipids differentially affects detergent insolubility and apical sorting. 2000 Mol. Biol. Cell pmid:10679012
Smith SJ et al. A Novel Function for Arabidopsis CYCLASE1 in Programmed Cell Death Revealed by Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) Analysis of Extracellular Matrix Proteins. 2015 Mol. Cell Proteomics pmid:25862728
Chivasa S et al. Proteomic analysis of extracellular ATP-regulated proteins identifies ATP synthase beta-subunit as a novel plant cell death regulator. 2011 Mol. Cell Proteomics pmid:21156838
Ghosh S et al. Generation of ceramide in murine macrophages infected with Leishmania donovani alters macrophage signaling events and aids intracellular parasitic survival. 2001 Mol. Cell. Biochem. pmid:11681721
Giussani P et al. Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. 2006 Mol. Cell. Biol. pmid:16782891
Laudati E et al. The activities of LDL Receptor-related Protein-1 (LRP1) compartmentalize into distinct plasma membrane microdomains. 2016 Mol. Cell. Neurosci. pmid:27565578
Chang MC et al. Inhibition of sphingolipid synthesis affects kinetics but not fidelity of L1/NgCAM transport along direct but not transcytotic axonal pathways. 2006 Mol. Cell. Neurosci. pmid:16376103
Hayashi T and Fujimoto M Detergent-resistant microdomains determine the localization of sigma-1 receptors to the endoplasmic reticulum-mitochondria junction. 2010 Mol. Pharmacol. pmid:20053954
Brandwagt BF et al. Overexpression of the tomato Asc-1 gene mediates high insensitivity to AAL toxins and fumonisin B1 in tomato hairy roots and confers resistance to Alternaria alternata f. sp. lycopersici in Nicotiana umbratica plants. 2002 Mol. Plant Microbe Interact. pmid:11858172
Wang L et al. OsLSD1, a rice zinc finger protein, regulates programmed cell death and callus differentiation. 2005 Mol. Plant Microbe Interact. pmid:15915636
Bluhm BH and Woloshuk CP Amylopectin induces fumonisin B1 production by Fusarium verticillioides during colonization of maize kernels. 2005 Mol. Plant Microbe Interact. pmid:16478053
Desjardins AE et al. FUM1--a gene required for fumonisin biosynthesis but not for maize ear rot and ear infection by Gibberella moniliformis in field tests. 2002 Mol. Plant Microbe Interact. pmid:12423021
Niu C et al. Involvement of FST1 from Fusarium verticillioides in virulence and transport of inositol. 2017 Mol. Plant Pathol. pmid:27195938
Oh M et al. Transcription factor ART1 mediates starch hydrolysis and mycotoxin production in Fusarium graminearum and F. verticillioides. 2016 Mol. Plant Pathol. pmid:26456718
Ehrlich V et al. Fumonisin B(1) is genotoxic in human derived hepatoma (HepG2) cells. 2002 Mutagenesis pmid:11971998
Aranda M et al. Assessment of in vitro mutagenicity in Salmonella and in vivo genotoxicity in mice of the mycotoxin fumonisin B(1). 2000 Mutagenesis pmid:11076997
Knasmüller S et al. Genotoxic effects of three Fusarium mycotoxins, fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes. 1997 Mutat. Res. pmid:9219547
Turner PC et al. Fumonisin contamination of food: progress in development of biomarkers to better assess human health risks. 1999 Mutat. Res. pmid:10415433
Castellá G et al. Mycoflora and fumonisin-producing strains of Fusarium moniliforme in mixed poultry feeds and component raw material. 1996 Mycopathologia pmid:8927120
Javed T et al. Comparative pathologic changes in broiler chicks on feed amended with Fusarium proliferatum culture material or purified fumonisin B1 and moniliformin. 2005 Mycopathologia pmid:15983742
Voss KA et al. Comparative studies of hepatotoxicity and fumonisin B1 and B2 content of water and chloroform/methanol extracts of Fusarium moniliforme strain MRC 826 culture material. 1990 Mycopathologia pmid:2293036
Gross SM et al. Developmental effects of fumonisin B1-containing Fusarium moniliforme culture extract in CD1 mice. 1994 Mycopathologia pmid:7777035
Wu W et al. Comparative cytotoxicity of fumonisin B1 and moniliformin in chicken primary cell cultures. 1995 Mycopathologia pmid:8819833
Ganassi S et al. Effect of Fusarium, Paecilomyces and Trichoderma formulations against aphid Schizaphis graminum. 2001 Mycopathologia pmid:11678587
Bacon CW et al. Toxic interaction of fumonisin B1 and fusaric acid measured by injection into fertile chicken egg. 1995 Mycopathologia pmid:7617015
Julian AM et al. Fungal contamination and selected mycotoxins in pre- and post-harvest maize in Honduras. 1995 Mycopathologia pmid:7617016
Vismer HF et al. Production of fumonisins by Fusarium verticillioides strains on solid and in a defined liquid medium--effects of L-methionine and inoculum. 2004 Mycopathologia pmid:15487327