| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Salcedo M et al. | The marine sphingolipid-derived compound ES 285 triggers an atypical cell death pathway. | 2007 | Apoptosis | pmid:17191124 |
| Sánchez AM et al. | Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation. | 2008 | Eur. J. Pharmacol. | pmid:18343365 |
| Pruett ST et al. | Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. | 2008 | J. Lipid Res. | pmid:18499644 |
| Baird RD et al. | Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors. | 2009 | Mol. Cancer Ther. | pmid:19509256 |
| Bertea M et al. | Deoxysphingoid bases as plasma markers in diabetes mellitus. | 2010 | Lipids Health Dis | pmid:20712864 |
| Garofalo K et al. | Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1. | 2011 | J. Clin. Invest. | pmid:22045570 |
| Scherer SS | The debut of a rational treatment for an inherited neuropathy? | 2011 | J. Clin. Invest. | pmid:22045569 |
| Rotthier A et al. | Characterization of two mutations in the SPTLC1 subunit of serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathy type I. | 2011 | Hum. Mutat. | pmid:21618344 |
| Merrill AH | Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. | 2011 | Chem. Rev. | pmid:21942574 |
| Schöffski P et al. | Spisulosine (ES-285) given as a weekly three-hour intravenous infusion: results of a phase I dose-escalating study in patients with advanced solid malignancies. | 2011 | Cancer Chemother. Pharmacol. | pmid:21465314 |
Spisulosine
Spisulosine is a lipid of Sphingolipids (SP) class. Spisulosine is associated with abnormalities such as Infection, Renal impairment and Lesion of brain. The involved functions are known as Gene Expression, Cell Cycle, Drug Kinetics, Signal Transduction and Cell Cycle Arrest. Spisulosine often locates in Body tissue, Microfilaments, Skin, Stress Fibers and Tissue specimen.
Cross Reference
Introduction
To understand associated biological information of Spisulosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Spisulosine?
Spisulosine is suspected in Infection, Renal impairment, Lesion of brain and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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No disease MeSH terms mapped to the current reference collection.
PubChem Associated disorders and diseases
What pathways are associated with Spisulosine
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Spisulosine?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Spisulosine?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Spisulosine?
There are no associated biomedical information in the current reference collection.
What genes are associated with Spisulosine?
There are no associated biomedical information in the current reference collection.
What common seen animal models are associated with Spisulosine?
There are no associated biomedical information in the current reference collection.