Spisulosine

Spisulosine is a lipid of Sphingolipids (SP) class. Spisulosine is associated with abnormalities such as Infection, Renal impairment and Lesion of brain. The involved functions are known as Gene Expression, Cell Cycle, Drug Kinetics, Signal Transduction and Cell Cycle Arrest. Spisulosine often locates in Body tissue, Microfilaments, Skin, Stress Fibers and Tissue specimen.

Cross Reference

Introduction

To understand associated biological information of Spisulosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Spisulosine?

Spisulosine is suspected in Infection, Renal impairment, Lesion of brain and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Spisulosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Spisulosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Spisulosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Spisulosine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Spisulosine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Spisulosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Spisulosine

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Authors Title Published Journal PubMed Link
Garofalo K et al. Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1. 2011 J. Clin. Invest. pmid:22045570
Scherer SS The debut of a rational treatment for an inherited neuropathy? 2011 J. Clin. Invest. pmid:22045569
Steiner R et al. Elucidating the chemical structure of native 1-deoxysphingosine. 2016 J. Lipid Res. pmid:27165858
Pruett ST et al. Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols. 2008 J. Lipid Res. pmid:18499644
Calder ED et al. Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-sphinganine, (+)-spisulosine, and D-ribo-phytosphingosine. 2013 J. Org. Chem. pmid:23795558
Abad JL et al. Straightforward access to spisulosine and 4,5-dehydrospisulosine stereoisomers: probes for profiling ceramide synthase activities in intact cells. 2013 J. Org. Chem. pmid:23679346
Yun JM et al. Efficient synthesis of enantiomerically pure 2-acylaziridines: Facile syntheses of N-Boc-safingol, N-Boc-D-erythro-sphinganine, and N-Boc-spisulosine from a common intermediate. 2003 J. Org. Chem. pmid:14510541
Malik G et al. Aziridines from intramolecular alkene aziridination of sulfamates: reactivity toward carbon nucleophiles. application to the synthesis of spisulosine and its fluoro analogue. 2011 J. Org. Chem. pmid:21812488
Wei N et al. Altered sphingoid base profiles in type 1 compared to type 2 diabetes. 2014 Lipids Health Dis pmid:25305670
Bertea M et al. Deoxysphingoid bases as plasma markers in diabetes mellitus. 2010 Lipids Health Dis pmid:20712864