Spisulosine

Spisulosine is a lipid of Sphingolipids (SP) class. Spisulosine is associated with abnormalities such as Infection, Renal impairment and Lesion of brain. The involved functions are known as Gene Expression, Cell Cycle, Drug Kinetics, Signal Transduction and Cell Cycle Arrest. Spisulosine often locates in Body tissue, Microfilaments, Skin, Stress Fibers and Tissue specimen.

Cross Reference

Introduction

To understand associated biological information of Spisulosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Spisulosine?

Spisulosine is suspected in Infection, Renal impairment, Lesion of brain and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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No disease MeSH terms mapped to the current reference collection.

PubChem Associated disorders and diseases

What pathways are associated with Spisulosine

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Spisulosine?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Spisulosine?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Spisulosine?

There are no associated biomedical information in the current reference collection.

What genes are associated with Spisulosine?

There are no associated biomedical information in the current reference collection.

What common seen animal models are associated with Spisulosine?

There are no associated biomedical information in the current reference collection.

NCBI Entrez Crosslinks

All references with Spisulosine

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Authors Title Published Journal PubMed Link
Chen BS et al. Diastereoselective synthesis and bioactivity of long-chain anti-2-amino-3-alkanols. 2011 Eur J Med Chem pmid:21955681
Scherer SS The debut of a rational treatment for an inherited neuropathy? 2011 J. Clin. Invest. pmid:22045569
Garofalo K et al. Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1. 2011 J. Clin. Invest. pmid:22045570
Massard C et al. Phase I dose-escalating study of ES-285 given as a three-hour intravenous infusion every three weeks in patients with advanced malignant solid tumors. 2012 Invest New Drugs pmid:22215532
Xu K et al. A highly anti-selective asymmetric Henry reaction catalyzed by a chiral copper complex: applications to the syntheses of (+)-spisulosine and a pyrroloisoquinoline derivative. 2012 Chemistry pmid:22907874
Abad JL et al. Straightforward access to spisulosine and 4,5-dehydrospisulosine stereoisomers: probes for profiling ceramide synthase activities in intact cells. 2013 J. Org. Chem. pmid:23679346
Calder ED et al. Preparation of anti-vicinal amino alcohols: asymmetric synthesis of D-erythro-sphinganine, (+)-spisulosine, and D-ribo-phytosphingosine. 2013 J. Org. Chem. pmid:23795558
Zuellig RA et al. Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells. 2014 Diabetes pmid:24379346
Byun HS et al. Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells. 2013 Medchemcomm pmid:24396570
Kowluru A Deoxysphingolipids: β-cell, beware of these new kids on the block. 2014 Diabetes pmid:24651803