Laurylsphingosine is a lipid of Sphingolipids (SP) class. Laurylsphingosine is associated with abnormalities such as BOSLEY-SALIH-ALORAINY SYNDROME, Obesity and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as ceramide biosynthetic process, Anabolism, Signal, Signal Transduction and Transcriptional Activation. Laurylsphingosine often locates in Protoplasm, Plasma membrane, Epidermis, lamellar body and Stratum corneum. The associated genes with Laurylsphingosine are CFB gene. The related lipids are Nonesterified Fatty Acids, Fatty Acids, Sphingolipids, Palmitates and Stearates.
To understand associated biological information of Laurylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Laurylsphingosine is suspected in Obesity, BOSLEY-SALIH-ALORAINY SYNDROME, Diabetes Mellitus, Non-Insulin-Dependent and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Laurylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Gill JS and Windebank AJ | Suramin induced ceramide accumulation leads to apoptotic cell death in dorsal root ganglion neurons. | 1998 | Cell Death Differ. | pmid:10203686 |
| Di Marzio L et al. | Effect of the lactic acid bacterium Streptococcus thermophilus on ceramide levels in human keratinocytes in vitro and stratum corneum in vivo. | 1999 | J. Invest. Dermatol. | pmid:10417626 |
| Farina F et al. | Involvement of caspase-3 and GD3 ganglioside in ceramide-induced apoptosis in Farber disease. | 2000 | J. Histochem. Cytochem. | pmid:10653586 |
| Bektas M et al. | Different vitamin D analogues induce sphingomyelin hydrolysis and apoptosis in the human keratinocyte cell line HaCaT. | 2000 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:10726977 |
| GarcÃa-Ruiz C et al. | Human placenta sphingomyelinase, an exogenous acidic pH-optimum sphingomyelinase, induces oxidative stress, glutathione depletion, and apoptosis in rat hepatocytes. | 2000 | Hepatology | pmid:10869289 |
| Tanno O et al. | Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. | 2000 | Br. J. Dermatol. | pmid:10971324 |
| van Lijnschoten G et al. | Intrauterine fetal death due to Farber disease: case report. | 2000 Nov-Dec | Pediatr. Dev. Pathol. | pmid:11000338 |
| Grether-Beck S et al. | Non-enzymatic triggering of the ceramide signalling cascade by solar UVA radiation. | 2000 | EMBO J. | pmid:11060030 |
| Sugiki H et al. | C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line. | 2000 | Br. J. Dermatol. | pmid:11122015 |
| Poliak S et al. | Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon. | 2001 | J. Neurosci. | pmid:11567047 |
| Vielhaber G et al. | Localization of ceramide and glucosylceramide in human epidermis by immunogold electron microscopy. | 2001 | J. Invest. Dermatol. | pmid:11710923 |
| Uchida Y et al. | Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures. | 2001 | J. Invest. Dermatol. | pmid:11710949 |
| Kirby RJ et al. | Bile salt-stimulated carboxyl ester lipase influences lipoprotein assembly and secretion in intestine: a process mediated via ceramide hydrolysis. | 2002 | J. Biol. Chem. | pmid:11733511 |
| Bouwstra JA et al. | Structure of the skin barrier and its modulation by vesicular formulations. | 2003 | Prog. Lipid Res. | pmid:12467638 |
| Humbert P | [Functional consequences of cutaneous lipid perturbation]. | 2003 | Pathol. Biol. | pmid:14567193 |
| Adams JM et al. | Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. | 2004 | Diabetes | pmid:14693694 |
| Di Marzio L et al. | Effect of the lactic acid bacterium Streptococcus thermophilus on stratum corneum ceramide levels and signs and symptoms of atopic dermatitis patients. | 2003 | Exp. Dermatol. | pmid:14705802 |
| Malagarie-Cazenave S et al. | Role of FAN in tumor necrosis factor-alpha and lipopolysaccharide-induced interleukin-6 secretion and lethality in D-galactosamine-sensitized mice. | 2004 | J. Biol. Chem. | pmid:14985352 |
| Marà M et al. | Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis. | 2004 | J. Clin. Invest. | pmid:15067322 |