Laurylsphingosine is a lipid of Sphingolipids (SP) class. Laurylsphingosine is associated with abnormalities such as BOSLEY-SALIH-ALORAINY SYNDROME, Obesity and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as ceramide biosynthetic process, Anabolism, Signal, Signal Transduction and Transcriptional Activation. Laurylsphingosine often locates in Protoplasm, Plasma membrane, Epidermis, lamellar body and Stratum corneum. The associated genes with Laurylsphingosine are CFB gene. The related lipids are Nonesterified Fatty Acids, Fatty Acids, Sphingolipids, Palmitates and Stearates.
To understand associated biological information of Laurylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Laurylsphingosine is suspected in Obesity, BOSLEY-SALIH-ALORAINY SYNDROME, Diabetes Mellitus, Non-Insulin-Dependent and other diseases in descending order of the highest number of associated sentences.
| Disease | Cross reference | Weighted score | Related literature |
|---|
We collected disease MeSH terms mapped to the references associated with Laurylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Hypothyroidism | D007037 | 32 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Zellweger Syndrome | D015211 | 39 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Saito M et al. | Ethanol-induced changes in the content of triglycerides, ceramides, and glucosylceramides in cultured neurons. | 2005 | Alcohol. Clin. Exp. Res. | pmid:16131844 |
| Persaud-Sawin DA and Boustany RM | Cell death pathways in juvenile Batten disease. | 2005 | Apoptosis | pmid:16151633 |
| Momoi T et al. | Substrate-specificities of acid and alkaline ceramidases in fibroblasts from patients with Farber disease and controls. | 1982 | Biochem. J. | pmid:6814427 |
| Park J et al. | Inhibition of interleukin-4 production in activated T cells via the downregulation of AP-1/NF-AT activation by N-lauroyl-D-erythro-sphingosine and N-lauroyl-D-erythro-C20-sphingosine. | 2006 | Biochem. Pharmacol. | pmid:16448625 |
| Futerman AH | The roles of ceramide in the regulation of neuronal growth and development. | 1998 | Biochemistry Mosc. | pmid:9526098 |
| Erdreich-Epstein A et al. | Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways. | 2005 | Blood | pmid:15705795 |
| Sugiki H et al. | C2-ceramide induces apoptosis in a human squamous cell carcinoma cell line. | 2000 | Br. J. Dermatol. | pmid:11122015 |
| Tanno O et al. | Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. | 2000 | Br. J. Dermatol. | pmid:10971324 |
| Demarchi F et al. | Ceramide triggers an NF-kappaB-dependent survival pathway through calpain. | 2005 | Cell Death Differ. | pmid:15933726 |
| Gill JS and Windebank AJ | Suramin induced ceramide accumulation leads to apoptotic cell death in dorsal root ganglion neurons. | 1998 | Cell Death Differ. | pmid:10203686 |
| Bektas M et al. | Different vitamin D analogues induce sphingomyelin hydrolysis and apoptosis in the human keratinocyte cell line HaCaT. | 2000 | Cell. Mol. Biol. (Noisy-le-grand) | pmid:10726977 |
| Marchesini S et al. | Sulforhodamine GM1-ganglioside: synthesis and physicochemical properties. | 1994 | Chem. Phys. Lipids | pmid:7954976 |
| Ohnishi Y et al. | Ceramidase activity in bacterial skin flora as a possible cause of ceramide deficiency in atopic dermatitis. | 1999 | Clin. Diagn. Lab. Immunol. | pmid:9874672 |
| Adams JM et al. | Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. | 2004 | Diabetes | pmid:14693694 |
| Grether-Beck S et al. | Non-enzymatic triggering of the ceramide signalling cascade by solar UVA radiation. | 2000 | EMBO J. | pmid:11060030 |
| Di Marzio L et al. | Effect of the lactic acid bacterium Streptococcus thermophilus on stratum corneum ceramide levels and signs and symptoms of atopic dermatitis patients. | 2003 | Exp. Dermatol. | pmid:14705802 |
| Helge JW et al. | Exercise and training effects on ceramide metabolism in human skeletal muscle. | 2004 | Exp. Physiol. | pmid:15109217 |
| GarcÃa-Ruiz C et al. | Human placenta sphingomyelinase, an exogenous acidic pH-optimum sphingomyelinase, induces oxidative stress, glutathione depletion, and apoptosis in rat hepatocytes. | 2000 | Hepatology | pmid:10869289 |
| Tojo K et al. | Possible thyroidal involvement in a case of Fabry disease. | 1994 | Intern. Med. | pmid:8061397 |