N-Palmitoylsphingosine is a lipid of Sphingolipids (SP) class. The involved functions are known as ceramide biosynthetic process, Apoptosis, Regulation, Signal Transduction and Caspase-Dependent Apoptosis. N-palmitoylsphingosine often locates in Mitochondria, Membrane, Extracellular and Endoplasmic Reticulum. The associated genes with N-Palmitoylsphingosine are BCL2 gene, cytochrome c'', BCL2L1 gene, LASS6 gene and LASS5 gene. The related lipids are dihydroceramide, Fatty Acids, Sphingolipids, Palmitates and inositolphosphorylceramide.
To understand associated biological information of N-Palmitoylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with N-Palmitoylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Bao JX et al. | Triggering role of acid sphingomyelinase in endothelial lysosome-membrane fusion and dysfunction in coronary arteries. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20061541 |
| Gorgoglione V et al. | Ceramide-induced activation of cytosolic NADH/cytochrome c electron transport pathway: An additional source of energy for apoptosis. | 2010 | Arch. Biochem. Biophys. | pmid:20850412 |
| Deroyer C et al. | New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway. | 2014 | Autophagy | pmid:24819607 |
| Grassmé H et al. | Molecular mechanisms of ceramide-mediated CD95 clustering. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11409897 |
| Bock J et al. | Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12767914 |
| Hinz B et al. | R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474472 |
| Tserng KY and Griffin RL | Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity. | 2004 | Biochem. J. | pmid:14998372 |
| Beverly LJ et al. | BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins. | 2013 | Biochem. J. | pmid:23480852 |
| Fillet M et al. | Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity. | 2003 | Biochem. Pharmacol. | pmid:12754099 |