N-Palmitoylsphingosine is a lipid of Sphingolipids (SP) class. The involved functions are known as ceramide biosynthetic process, Apoptosis, Regulation, Signal Transduction and Caspase-Dependent Apoptosis. N-palmitoylsphingosine often locates in Mitochondria, Membrane, Extracellular and Endoplasmic Reticulum. The associated genes with N-Palmitoylsphingosine are BCL2 gene, cytochrome c'', BCL2L1 gene, LASS6 gene and LASS5 gene. The related lipids are dihydroceramide, Fatty Acids, Sphingolipids, Palmitates and inositolphosphorylceramide.
To understand associated biological information of N-Palmitoylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with N-Palmitoylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mandal P et al. | Cholesterol Depletion from a Ceramide/Cholesterol Mixed Monolayer: A Brewster Angle Microscope Study. | 2016 | Sci Rep | pmid:27245215 |
| Eto M et al. | C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells. | 2003 | Prostate | pmid:12886525 |
| Laudanski P et al. | Plasma C16-Cer levels are increased in patients with preterm labor. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:27184754 |
| Panjarian S et al. | De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18400537 |
| Truman JP et al. | Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. | 2010 | PLoS ONE | pmid:20941382 |
| Itoi T et al. | Modulation of C16:0-ceramide in hypertrophied immature hearts by losartan. | 2013 | Pediatr Int | pmid:23316794 |
| Scholl A et al. | Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. | 2016 | Oncotarget | pmid:27556861 |
| Liu F et al. | Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells. | 2016 | Oncotarget | pmid:27880732 |
| Grammatikos G et al. | Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. | 2016 | Oncotarget | pmid:26933996 |
| White-Gilbertson S et al. | Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. | 2009 | Oncogene | pmid:19137010 |