N-Palmitoylsphingosine is a lipid of Sphingolipids (SP) class. The involved functions are known as ceramide biosynthetic process, Apoptosis, Regulation, Signal Transduction and Caspase-Dependent Apoptosis. N-palmitoylsphingosine often locates in Mitochondria, Membrane, Extracellular and Endoplasmic Reticulum. The associated genes with N-Palmitoylsphingosine are BCL2 gene, cytochrome c'', BCL2L1 gene, LASS6 gene and LASS5 gene. The related lipids are dihydroceramide, Fatty Acids, Sphingolipids, Palmitates and inositolphosphorylceramide.
To understand associated biological information of N-Palmitoylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with N-Palmitoylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Shah J et al. | Structural and thermotropic properties of synthetic C16:0 (palmitoyl) ceramide: effect of hydration. | 1995 | J. Lipid Res. | pmid:8558082 |
| Holopainen JM et al. | Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane. | 1998 | Biochemistry | pmid:9860872 |
| Payne SG et al. | Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts. | 1999 | J. Cell. Physiol. | pmid:10395296 |
| Vartanian A et al. | Ap4A induces apoptosis in human cultured cells. | 1999 | FEBS Lett. | pmid:10452553 |
| Siskind LJ and Colombini M | The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis. | 2000 | J. Biol. Chem. | pmid:11027675 |
| Holopainen JM et al. | Dimyristoylphosphatidylcholine/C16:0-ceramide binary liposomes studied by differential scanning calorimetry and wide- and small-angle x-ray scattering. | 2000 | Biophys. J. | pmid:10777742 |
| Kroesen BJ et al. | Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. | 2001 | J. Biol. Chem. | pmid:11278517 |
| Singh IN et al. | Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate. | 2001 | Biochemistry | pmid:11551222 |
| Duclos RI | The total syntheses of D-erythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine analog. | 2001 | Chem. Phys. Lipids | pmid:11457441 |
| Grassmé H et al. | Molecular mechanisms of ceramide-mediated CD95 clustering. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11409897 |
| Holopainen JM et al. | Interfacial interactions of ceramide with dimyristoylphosphatidylcholine: impact of the N-acyl chain. | 2001 | Biophys. J. | pmid:11159444 |
| Siskind LJ et al. | Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. | 2002 | J. Biol. Chem. | pmid:12006562 |
| Hsueh YW et al. | The effect of ceramide on phosphatidylcholine membranes: a deuterium NMR study. | 2002 | Biophys. J. | pmid:12023232 |
| Koyanagi S et al. | Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase. | 2003 | Int. J. Cancer | pmid:12672022 |
| Bock J et al. | Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12767914 |
| Fillet M et al. | Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity. | 2003 | Biochem. Pharmacol. | pmid:12754099 |
| Kroesen BJ et al. | BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. | 2003 | J. Biol. Chem. | pmid:12578840 |
| Eto M et al. | C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells. | 2003 | Prostate | pmid:12886525 |
| Abdel Shakor AB et al. | Cell surface ceramide generation precedes and controls FcgammaRII clustering and phosphorylation in rafts. | 2004 | J. Biol. Chem. | pmid:15194692 |