N-Palmitoylsphingosine is a lipid of Sphingolipids (SP) class. The involved functions are known as ceramide biosynthetic process, Apoptosis, Regulation, Signal Transduction and Caspase-Dependent Apoptosis. N-palmitoylsphingosine often locates in Mitochondria, Membrane, Extracellular and Endoplasmic Reticulum. The associated genes with N-Palmitoylsphingosine are BCL2 gene, cytochrome c'', BCL2L1 gene, LASS6 gene and LASS5 gene. The related lipids are dihydroceramide, Fatty Acids, Sphingolipids, Palmitates and inositolphosphorylceramide.
To understand associated biological information of N-Palmitoylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with N-Palmitoylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
| Location | Cross reference | Weighted score | Related literatures |
|---|
| Function | Cross reference | Weighted score | Related literatures |
|---|
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
| Gene | Cross reference | Weighted score | Related literatures |
|---|
There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Murthy AVR et al. | Palmitoyl ceramide promotes milk sphingomyelin gel phase domains formation and affects the mechanical properties of the fluid phase in milk-SM/DOPC supported membranes. | 2018 | Biochim. Biophys. Acta | pmid:29229528 |
| Doroudgar M and Lafleur M | Ceramide-C16 Is a Versatile Modulator of Phosphatidylethanolamine Polymorphism. | 2017 | Biophys. J. | pmid:28591608 |
| Xie C et al. | An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice. | 2017 | Diabetes | pmid:28223344 |
| Jiang Z et al. | LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity. | 2016 | Curr. Mol. Med. | pmid:27280497 |
| Perera MN et al. | Ceramide channel: Structural basis for selective membrane targeting. | 2016 | Chem. Phys. Lipids | pmid:26408265 |
| Scholl A et al. | Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. | 2016 | Oncotarget | pmid:27556861 |
| Alsahli A et al. | Palmitic Acid Reduces Circulating Bone Formation Markers in Obese Animals and Impairs Osteoblast Activity via C16-Ceramide Accumulation. | 2016 | Calcif. Tissue Int. | pmid:26758875 |
| Laudanski P et al. | Plasma C16-Cer levels are increased in patients with preterm labor. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:27184754 |
| Liu F et al. | Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells. | 2016 | Oncotarget | pmid:27880732 |
| Mandal P et al. | Cholesterol Depletion from a Ceramide/Cholesterol Mixed Monolayer: A Brewster Angle Microscope Study. | 2016 | Sci Rep | pmid:27245215 |
| Grammatikos G et al. | Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. | 2016 | Oncotarget | pmid:26933996 |
| Su X et al. | Co-delivery of doxorubicin and PEGylated C16-ceramide by nanoliposomes for enhanced therapy against multidrug resistance. | 2015 | Nanomedicine (Lond) | pmid:26084553 |
| GarcÃa-Arribas AB et al. | Atomic force microscopy characterization of palmitoylceramide and cholesterol effects on phospholipid bilayers: a topographic and nanomechanical study. | 2015 | Langmuir | pmid:25693914 |
| Deroyer C et al. | New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway. | 2014 | Autophagy | pmid:24819607 |
| Dutagaci B et al. | Ceramide-lipid interactions studied by MD simulations and solid-state NMR. | 2014 | Biochim. Biophys. Acta | pmid:24882733 |
| Busto JV et al. | Lamellar gel (lβ) phases of ternary lipid composition containing ceramide and cholesterol. | 2014 | Biophys. J. | pmid:24507602 |
| Yang Y et al. | Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. | 2014 | Lipids | pmid:24777581 |
| Gorshkova IA et al. | Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest. | 2013 | Life Sci. | pmid:23892195 |
| Beverly LJ et al. | BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins. | 2013 | Biochem. J. | pmid:23480852 |
| Itoi T et al. | Modulation of C16:0-ceramide in hypertrophied immature hearts by losartan. | 2013 | Pediatr Int | pmid:23316794 |