N-Palmitoylsphingosine is a lipid of Sphingolipids (SP) class. The involved functions are known as ceramide biosynthetic process, Apoptosis, Regulation, Signal Transduction and Caspase-Dependent Apoptosis. N-palmitoylsphingosine often locates in Mitochondria, Membrane, Extracellular and Endoplasmic Reticulum. The associated genes with N-Palmitoylsphingosine are BCL2 gene, cytochrome c'', BCL2L1 gene, LASS6 gene and LASS5 gene. The related lipids are dihydroceramide, Fatty Acids, Sphingolipids, Palmitates and inositolphosphorylceramide.
To understand associated biological information of N-Palmitoylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with N-Palmitoylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| pmid: | ||||
| Shah J et al. | Structural and thermotropic properties of synthetic C16:0 (palmitoyl) ceramide: effect of hydration. | 1995 | J. Lipid Res. | pmid:8558082 |
| Holopainen JM et al. | Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane. | 1998 | Biochemistry | pmid:9860872 |
| Payne SG et al. | Epidermal growth factor inhibits ceramide-induced apoptosis and lowers ceramide levels in primary placental trophoblasts. | 1999 | J. Cell. Physiol. | pmid:10395296 |
| Vartanian A et al. | Ap4A induces apoptosis in human cultured cells. | 1999 | FEBS Lett. | pmid:10452553 |
| Siskind LJ and Colombini M | The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis. | 2000 | J. Biol. Chem. | pmid:11027675 |
| Holopainen JM et al. | Dimyristoylphosphatidylcholine/C16:0-ceramide binary liposomes studied by differential scanning calorimetry and wide- and small-angle x-ray scattering. | 2000 | Biophys. J. | pmid:10777742 |
| Kroesen BJ et al. | Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. | 2001 | J. Biol. Chem. | pmid:11278517 |
| Singh IN et al. | Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate. | 2001 | Biochemistry | pmid:11551222 |
| Duclos RI | The total syntheses of D-erythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine analog. | 2001 | Chem. Phys. Lipids | pmid:11457441 |
| Grassmé H et al. | Molecular mechanisms of ceramide-mediated CD95 clustering. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11409897 |
| Holopainen JM et al. | Interfacial interactions of ceramide with dimyristoylphosphatidylcholine: impact of the N-acyl chain. | 2001 | Biophys. J. | pmid:11159444 |
| Siskind LJ et al. | Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. | 2002 | J. Biol. Chem. | pmid:12006562 |
| Hsueh YW et al. | The effect of ceramide on phosphatidylcholine membranes: a deuterium NMR study. | 2002 | Biophys. J. | pmid:12023232 |
| Koyanagi S et al. | Elevation of de novo ceramide synthesis in tumor masses and the role of microsomal dihydroceramide synthase. | 2003 | Int. J. Cancer | pmid:12672022 |
| Bock J et al. | Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12767914 |
| Fillet M et al. | Mechanisms involved in exogenous C2- and C6-ceramide-induced cancer cell toxicity. | 2003 | Biochem. Pharmacol. | pmid:12754099 |
| Kroesen BJ et al. | BcR-induced apoptosis involves differential regulation of C16 and C24-ceramide formation and sphingolipid-dependent activation of the proteasome. | 2003 | J. Biol. Chem. | pmid:12578840 |
| Eto M et al. | C16 ceramide accumulates following androgen ablation in LNCaP prostate cancer cells. | 2003 | Prostate | pmid:12886525 |
| Hinz B et al. | R(+)-methanandamide-induced cyclooxygenase-2 expression in H4 human neuroglioma cells: possible involvement of membrane lipid rafts. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15474472 |
| Abdel Shakor AB et al. | Cell surface ceramide generation precedes and controls FcgammaRII clustering and phosphorylation in rafts. | 2004 | J. Biol. Chem. | pmid:15194692 |
| Tserng KY and Griffin RL | Ceramide metabolite, not intact ceramide molecule, may be responsible for cellular toxicity. | 2004 | Biochem. J. | pmid:14998372 |
| Perez GI et al. | A central role for ceramide in the age-related acceleration of apoptosis in the female germline. | 2005 | FASEB J. | pmid:15728664 |
| Mogami K et al. | Sphingomyelinase causes endothelium-dependent vasorelaxation through endothelial nitric oxide production without cytosolic Ca(2+) elevation. | 2005 | FEBS Lett. | pmid:15642349 |
| Sot J et al. | Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides. | 2005 | Biochim. Biophys. Acta | pmid:15904658 |
| Osawa Y et al. | Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. | 2005 | J. Biol. Chem. | pmid:15946935 |
| Dindo D et al. | Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. | 2006 | Mol. Cancer Ther. | pmid:16818511 |
| Taniguchi Y et al. | Rapid phase change of lipid microdomains in giant vesicles induced by conversion of sphingomyelin to ceramide. | 2006 | Biochim. Biophys. Acta | pmid:16580624 |
| Eto M et al. | Importance of C16 ceramide accumulation during apoptosis in prostate cancer cells. | 2006 | Int. J. Urol. | pmid:16563140 |
| Seumois G et al. | De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis. | 2007 | J. Leukoc. Biol. | pmid:17329567 |
| Panjarian S et al. | De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18400537 |
| White-Gilbertson S et al. | Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. | 2009 | Oncogene | pmid:19137010 |
| Morrow MR et al. | Ceramide-1-phosphate, in contrast to ceramide, is not segregated into lateral lipid domains in phosphatidylcholine bilayers. | 2009 | Biophys. J. | pmid:19289048 |
| Rénert AF et al. | The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells. | 2009 | J. Proteome Res. | pmid:19705920 |
| Busto JV et al. | Coexistence of immiscible mixtures of palmitoylsphingomyelin and palmitoylceramide in monolayers and bilayers. | 2009 | Biophys. J. | pmid:19917225 |
| Bao JX et al. | Triggering role of acid sphingomyelinase in endothelial lysosome-membrane fusion and dysfunction in coronary arteries. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20061541 |
| Schiffmann S et al. | Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide. | 2010 | Biochem. Pharmacol. | pmid:20735991 |
| Busto JV et al. | Cholesterol displaces palmitoylceramide from its tight packing with palmitoylsphingomyelin in the absence of a liquid-disordered phase. | 2010 | Biophys. J. | pmid:20712995 |
| Truman JP et al. | Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. | 2010 | PLoS ONE | pmid:20941382 |
| Senkal CE et al. | Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. | 2010 | FASEB J. | pmid:19723703 |
| Gorgoglione V et al. | Ceramide-induced activation of cytosolic NADH/cytochrome c electron transport pathway: An additional source of energy for apoptosis. | 2010 | Arch. Biochem. Biophys. | pmid:20850412 |
| Goldschmidt-Arzi M et al. | Intracellular localization of organized lipid domains of C16-ceramide/cholesterol. | 2011 | J. Struct. Biol. | pmid:21473916 |
| Hu X et al. | IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia. | 2011 | Cancer Res. | pmid:21487040 |
| Souza SL et al. | The thermotropism and prototropism of ternary mixtures of ceramide C16, cholesterol and palmitic acid. An exploratory study. | 2011 | Chem. Phys. Lipids | pmid:21723267 |
| Aflaki E et al. | C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. | 2012 | Cell Death Dis | pmid:22419109 |
| Epstein S et al. | Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells. | 2012 | J. Lipid Res. | pmid:22210926 |
| Leung SS et al. | Insights into sphingolipid miscibility: separate observation of sphingomyelin and ceramide N-acyl chain melting. | 2012 | Biophys. J. | pmid:23260048 |
| Gorshkova IA et al. | Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest. | 2013 | Life Sci. | pmid:23892195 |
| Beverly LJ et al. | BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins. | 2013 | Biochem. J. | pmid:23480852 |
| Itoi T et al. | Modulation of C16:0-ceramide in hypertrophied immature hearts by losartan. | 2013 | Pediatr Int | pmid:23316794 |