N-Palmitoylsphingosine is a lipid of Sphingolipids (SP) class. The involved functions are known as ceramide biosynthetic process, Apoptosis, Regulation, Signal Transduction and Caspase-Dependent Apoptosis. N-palmitoylsphingosine often locates in Mitochondria, Membrane, Extracellular and Endoplasmic Reticulum. The associated genes with N-Palmitoylsphingosine are BCL2 gene, cytochrome c'', BCL2L1 gene, LASS6 gene and LASS5 gene. The related lipids are dihydroceramide, Fatty Acids, Sphingolipids, Palmitates and inositolphosphorylceramide.
To understand associated biological information of N-Palmitoylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with N-Palmitoylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schiffmann S et al. | Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide. | 2010 | Biochem. Pharmacol. | pmid:20735991 |
| Singh IN et al. | Ceramide inhibition of mammalian phospholipase D1 and D2 activities is antagonized by phosphatidylinositol 4,5-bisphosphate. | 2001 | Biochemistry | pmid:11551222 |
| Holopainen JM et al. | Sphingomyelinase induces lipid microdomain formation in a fluid phosphatidylcholine/sphingomyelin membrane. | 1998 | Biochemistry | pmid:9860872 |
| Taniguchi Y et al. | Rapid phase change of lipid microdomains in giant vesicles induced by conversion of sphingomyelin to ceramide. | 2006 | Biochim. Biophys. Acta | pmid:16580624 |
| Dutagaci B et al. | Ceramide-lipid interactions studied by MD simulations and solid-state NMR. | 2014 | Biochim. Biophys. Acta | pmid:24882733 |
| Sot J et al. | Molecular associations and surface-active properties of short- and long-N-acyl chain ceramides. | 2005 | Biochim. Biophys. Acta | pmid:15904658 |
| Murthy AVR et al. | Palmitoyl ceramide promotes milk sphingomyelin gel phase domains formation and affects the mechanical properties of the fluid phase in milk-SM/DOPC supported membranes. | 2018 | Biochim. Biophys. Acta | pmid:29229528 |
| Busto JV et al. | Cholesterol displaces palmitoylceramide from its tight packing with palmitoylsphingomyelin in the absence of a liquid-disordered phase. | 2010 | Biophys. J. | pmid:20712995 |
| Busto JV et al. | Lamellar gel (lβ) phases of ternary lipid composition containing ceramide and cholesterol. | 2014 | Biophys. J. | pmid:24507602 |
| Hsueh YW et al. | The effect of ceramide on phosphatidylcholine membranes: a deuterium NMR study. | 2002 | Biophys. J. | pmid:12023232 |