N-Palmitoylsphingosine is a lipid of Sphingolipids (SP) class. The involved functions are known as ceramide biosynthetic process, Apoptosis, Regulation, Signal Transduction and Caspase-Dependent Apoptosis. N-palmitoylsphingosine often locates in Mitochondria, Membrane, Extracellular and Endoplasmic Reticulum. The associated genes with N-Palmitoylsphingosine are BCL2 gene, cytochrome c'', BCL2L1 gene, LASS6 gene and LASS5 gene. The related lipids are dihydroceramide, Fatty Acids, Sphingolipids, Palmitates and inositolphosphorylceramide.
To understand associated biological information of N-Palmitoylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with N-Palmitoylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gulbins E et al. | Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. | 2013 | Nat. Med. | pmid:23770692 |
| Aflaki E et al. | C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. | 2012 | Cell Death Dis | pmid:22419109 |
| Epstein S et al. | Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells. | 2012 | J. Lipid Res. | pmid:22210926 |
| Leung SS et al. | Insights into sphingolipid miscibility: separate observation of sphingomyelin and ceramide N-acyl chain melting. | 2012 | Biophys. J. | pmid:23260048 |
| Goldschmidt-Arzi M et al. | Intracellular localization of organized lipid domains of C16-ceramide/cholesterol. | 2011 | J. Struct. Biol. | pmid:21473916 |
| Hu X et al. | IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia. | 2011 | Cancer Res. | pmid:21487040 |
| Souza SL et al. | The thermotropism and prototropism of ternary mixtures of ceramide C16, cholesterol and palmitic acid. An exploratory study. | 2011 | Chem. Phys. Lipids | pmid:21723267 |
| Bao JX et al. | Triggering role of acid sphingomyelinase in endothelial lysosome-membrane fusion and dysfunction in coronary arteries. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20061541 |
| Schiffmann S et al. | Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide. | 2010 | Biochem. Pharmacol. | pmid:20735991 |
| Busto JV et al. | Cholesterol displaces palmitoylceramide from its tight packing with palmitoylsphingomyelin in the absence of a liquid-disordered phase. | 2010 | Biophys. J. | pmid:20712995 |
| Truman JP et al. | Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery. | 2010 | PLoS ONE | pmid:20941382 |
| Senkal CE et al. | Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. | 2010 | FASEB J. | pmid:19723703 |
| Gorgoglione V et al. | Ceramide-induced activation of cytosolic NADH/cytochrome c electron transport pathway: An additional source of energy for apoptosis. | 2010 | Arch. Biochem. Biophys. | pmid:20850412 |
| White-Gilbertson S et al. | Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells. | 2009 | Oncogene | pmid:19137010 |
| Morrow MR et al. | Ceramide-1-phosphate, in contrast to ceramide, is not segregated into lateral lipid domains in phosphatidylcholine bilayers. | 2009 | Biophys. J. | pmid:19289048 |
| Rénert AF et al. | The proapoptotic C16-ceramide-dependent pathway requires the death-promoting factor Btf in colon adenocarcinoma cells. | 2009 | J. Proteome Res. | pmid:19705920 |
| Busto JV et al. | Coexistence of immiscible mixtures of palmitoylsphingomyelin and palmitoylceramide in monolayers and bilayers. | 2009 | Biophys. J. | pmid:19917225 |
| Panjarian S et al. | De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18400537 |
| Seumois G et al. | De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis. | 2007 | J. Leukoc. Biol. | pmid:17329567 |
| Dindo D et al. | Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. | 2006 | Mol. Cancer Ther. | pmid:16818511 |