N-Palmitoylsphingosine is a lipid of Sphingolipids (SP) class. The involved functions are known as ceramide biosynthetic process, Apoptosis, Regulation, Signal Transduction and Caspase-Dependent Apoptosis. N-palmitoylsphingosine often locates in Mitochondria, Membrane, Extracellular and Endoplasmic Reticulum. The associated genes with N-Palmitoylsphingosine are BCL2 gene, cytochrome c'', BCL2L1 gene, LASS6 gene and LASS5 gene. The related lipids are dihydroceramide, Fatty Acids, Sphingolipids, Palmitates and inositolphosphorylceramide.
To understand associated biological information of N-Palmitoylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with N-Palmitoylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Doroudgar M and Lafleur M | Ceramide-C16 Is a Versatile Modulator of Phosphatidylethanolamine Polymorphism. | 2017 | Biophys. J. | pmid:28591608 |
| Holopainen JM et al. | Interfacial interactions of ceramide with dimyristoylphosphatidylcholine: impact of the N-acyl chain. | 2001 | Biophys. J. | pmid:11159444 |
| Holopainen JM et al. | Dimyristoylphosphatidylcholine/C16:0-ceramide binary liposomes studied by differential scanning calorimetry and wide- and small-angle x-ray scattering. | 2000 | Biophys. J. | pmid:10777742 |
| Morrow MR et al. | Ceramide-1-phosphate, in contrast to ceramide, is not segregated into lateral lipid domains in phosphatidylcholine bilayers. | 2009 | Biophys. J. | pmid:19289048 |
| Busto JV et al. | Coexistence of immiscible mixtures of palmitoylsphingomyelin and palmitoylceramide in monolayers and bilayers. | 2009 | Biophys. J. | pmid:19917225 |
| Hsueh YW et al. | The effect of ceramide on phosphatidylcholine membranes: a deuterium NMR study. | 2002 | Biophys. J. | pmid:12023232 |
| Alsahli A et al. | Palmitic Acid Reduces Circulating Bone Formation Markers in Obese Animals and Impairs Osteoblast Activity via C16-Ceramide Accumulation. | 2016 | Calcif. Tissue Int. | pmid:26758875 |
| Hu X et al. | IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia. | 2011 | Cancer Res. | pmid:21487040 |
| Aflaki E et al. | C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. | 2012 | Cell Death Dis | pmid:22419109 |
| Duclos RI | The total syntheses of D-erythro-sphingosine, N-palmitoylsphingosine (ceramide), and glucosylceramide (cerebroside) via an azidosphingosine analog. | 2001 | Chem. Phys. Lipids | pmid:11457441 |