N-Palmitoylsphingosine is a lipid of Sphingolipids (SP) class. The involved functions are known as ceramide biosynthetic process, Apoptosis, Regulation, Signal Transduction and Caspase-Dependent Apoptosis. N-palmitoylsphingosine often locates in Mitochondria, Membrane, Extracellular and Endoplasmic Reticulum. The associated genes with N-Palmitoylsphingosine are BCL2 gene, cytochrome c'', BCL2L1 gene, LASS6 gene and LASS5 gene. The related lipids are dihydroceramide, Fatty Acids, Sphingolipids, Palmitates and inositolphosphorylceramide.
To understand associated biological information of N-Palmitoylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
There are no associated biomedical information in the current reference collection.
We collected disease MeSH terms mapped to the references associated with N-Palmitoylsphingosine
| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Insulinoma | D007340 | 28 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Myeloid | D007951 | 52 associated lipids |
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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| Function | Cross reference | Weighted score | Related literatures |
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| Lipid concept | Cross reference | Weighted score | Related literatures |
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| Gene | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Schiffmann S et al. | Activation of ceramide synthase 6 by celecoxib leads to a selective induction of C16:0-ceramide. | 2010 | Biochem. Pharmacol. | pmid:20735991 |
| Goldschmidt-Arzi M et al. | Intracellular localization of organized lipid domains of C16-ceramide/cholesterol. | 2011 | J. Struct. Biol. | pmid:21473916 |
| Hu X et al. | IRF8 regulates acid ceramidase expression to mediate apoptosis and suppresses myelogeneous leukemia. | 2011 | Cancer Res. | pmid:21487040 |
| Souza SL et al. | The thermotropism and prototropism of ternary mixtures of ceramide C16, cholesterol and palmitic acid. An exploratory study. | 2011 | Chem. Phys. Lipids | pmid:21723267 |
| Aflaki E et al. | C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. | 2012 | Cell Death Dis | pmid:22419109 |
| Epstein S et al. | Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells. | 2012 | J. Lipid Res. | pmid:22210926 |
| Leung SS et al. | Insights into sphingolipid miscibility: separate observation of sphingomyelin and ceramide N-acyl chain melting. | 2012 | Biophys. J. | pmid:23260048 |
| Gorshkova IA et al. | Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest. | 2013 | Life Sci. | pmid:23892195 |
| Gulbins E et al. | Acid sphingomyelinase-ceramide system mediates effects of antidepressant drugs. | 2013 | Nat. Med. | pmid:23770692 |
| Beverly LJ et al. | BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins. | 2013 | Biochem. J. | pmid:23480852 |
| Itoi T et al. | Modulation of C16:0-ceramide in hypertrophied immature hearts by losartan. | 2013 | Pediatr Int | pmid:23316794 |
| Deroyer C et al. | New role for EMD (emerin), a key inner nuclear membrane protein, as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway. | 2014 | Autophagy | pmid:24819607 |
| Dutagaci B et al. | Ceramide-lipid interactions studied by MD simulations and solid-state NMR. | 2014 | Biochim. Biophys. Acta | pmid:24882733 |
| Busto JV et al. | Lamellar gel (lβ) phases of ternary lipid composition containing ceramide and cholesterol. | 2014 | Biophys. J. | pmid:24507602 |
| Yang Y et al. | Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. | 2014 | Lipids | pmid:24777581 |
| Su X et al. | Co-delivery of doxorubicin and PEGylated C16-ceramide by nanoliposomes for enhanced therapy against multidrug resistance. | 2015 | Nanomedicine (Lond) | pmid:26084553 |
| GarcÃa-Arribas AB et al. | Atomic force microscopy characterization of palmitoylceramide and cholesterol effects on phospholipid bilayers: a topographic and nanomechanical study. | 2015 | Langmuir | pmid:25693914 |
| Scholl A et al. | Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. | 2016 | Oncotarget | pmid:27556861 |
| Alsahli A et al. | Palmitic Acid Reduces Circulating Bone Formation Markers in Obese Animals and Impairs Osteoblast Activity via C16-Ceramide Accumulation. | 2016 | Calcif. Tissue Int. | pmid:26758875 |
| Laudanski P et al. | Plasma C16-Cer levels are increased in patients with preterm labor. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:27184754 |