N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Kralik SF et al. | Ceramide and glucosamine antagonism of alternate signaling pathways regulating insulin- and osmotic shock-induced glucose transporter 4 translocation. | 2002 | Endocrinology | pmid:11751589 |
Kawano Y et al. | Synergistic effect of interleukin-1alpha and ceramide analogue on production of prostaglandin E2 and F2alpha by endometrial stromal cells. | 2001 | Am. J. Reprod. Immunol. | pmid:11775008 |
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Cabrero A et al. | Increased reactive oxygen species production down-regulates peroxisome proliferator-activated alpha pathway in C2C12 skeletal muscle cells. | 2002 | J. Biol. Chem. | pmid:11792699 |
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Mansfield PJ et al. | Regulation of polymorphonuclear leukocyte degranulation and oxidant production by ceramide through inhibition of phospholipase D. | 2002 | Blood | pmid:11830497 |
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Han WS et al. | Effects of C2-ceramide on the Malme-3M melanoma cell line. | 2002 | J. Dermatol. Sci. | pmid:12354415 |
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Zhang YH et al. | Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons. | 2002 | J. Physiol. (Lond.) | pmid:12381813 |
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Phillips DC et al. | Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status. | 2002 | Arch. Biochem. Biophys. | pmid:12392710 |
Marques M et al. | Identification of platelet-activating factor acetylhydrolase II in human skin. | 2002 | J. Invest. Dermatol. | pmid:12406338 |
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Movsesyan VA et al. | Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12437970 |
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