N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
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Liu J et al. | Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide. | 2000 | Am. J. Physiol., Cell Physiol. | pmid:10644522 |
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Mihai R et al. | C2-Ceramide increases cytoplasmic calcium concentrations in human parathyroid cells. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10679256 |
Migita K et al. | Regulation of rheumatoid synovial cell growth by ceramide. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10694479 |
Galve-Roperh I et al. | Anti-tumoral action of cannabinoids: involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. | 2000 | Nat. Med. | pmid:10700234 |
Dawson G | Mechanisms of apoptosis in embryonic cortical neurons (E6 and E7) in culture involve lipid signalling, protein phosphorylation and caspase activation. | 2000 Apr-Jun | Int. J. Dev. Neurosci. | pmid:10715579 |
Lobner D | Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? | 2000 | J. Neurosci. Methods | pmid:10720679 |
Kondo T et al. | Suppression of heat shock protein-70 by ceramide in heat shock-induced HL-60 cell apoptosis. | 2000 | J. Biol. Chem. | pmid:10722733 |
Kim HS et al. | Induction of apoptosis by all-trans-retinoic acid and C2-ceramide treatment in rat stromal-vascular cultures. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10733907 |
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Ahmed N and Berridge MV | Ceramides that mediate apoptosis reduce glucose uptake and transporter affinity for glucose in human leukaemic cell lines but not in neutrophils. | 2000 | Pharmacol. Toxicol. | pmid:10752668 |
Yeh MW et al. | Cytokine-stimulated, but not HIV-infected, human monocyte-derived macrophages produce neurotoxic levels of l -cysteine. | 2000 | J. Immunol. | pmid:10754324 |
Paolucci C et al. | Nitric oxide inhibits the tumor necrosis factor alpha -regulated endocytosis of human dendritic cells in a cyclic GMP-dependent way. | 2000 | J. Biol. Chem. | pmid:10777484 |
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Takao N et al. | Protective roles for ATM in cellular response to oxidative stress. | 2000 | FEBS Lett. | pmid:10781820 |
De Nadai C et al. | Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10792026 |
Meadows KA et al. | Tumor necrosis factor-alpha-induced apoptosis is associated with suppression of insulin-like growth factor binding protein-5 secretion in differentiating murine skeletal myoblasts. | 2000 | J. Cell. Physiol. | pmid:10797307 |
Raisova M et al. | Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release. | 2000 | FEBS Lett. | pmid:10802053 |
Tavarini S et al. | Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells. | 2000 | Neurosci. Lett. | pmid:10806317 |
Chik CL et al. | Ceramide inhibits L-type calcium channel currents in rat pinealocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10810500 |
Knapp KM and English BK | Ceramide-mediated stimulation of inducible nitric oxide synthase (iNOS) and tumor necrosis factor (TNF) accumulation in murine macrophages requires tyrosine kinase activity. | 2000 | J. Leukoc. Biol. | pmid:10811015 |
Enomoto A et al. | Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4. | 2000 | Cancer Lett. | pmid:10822128 |
Posey SC et al. | Failure of gelsolin overexpression to regulate lymphocyte apoptosis. | 2000 | Blood | pmid:10828033 |
Campbell V and Lynch MA | The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1 beta in rat cortical synaptosomes. | 2000 | Cytokine | pmid:10857764 |
Pignata C et al. | Clustering of distinct autoimmune diseases associated with functional abnormalities of T cell survival in children. | 2000 | Clin. Exp. Immunol. | pmid:10886239 |
O'Byrne D and Sansom D | Lack of costimulation by both sphingomyelinase and C2 ceramide in resting human T cells. | 2000 | Immunology | pmid:10886399 |
Allan D et al. | Mechanisms by which short-chain ceramides cause apoptosis. | 1999 | Biochem. Soc. Trans. | pmid:10917615 |
Chae HJ et al. | Dexamethasone suppresses tumor necrosis factor-alpha-induced apoptosis in osteoblasts: possible role for ceramide. | 2000 | Endocrinology | pmid:10919278 |
Young KW et al. | Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells. | 2000 | Eur. J. Pharmacol. | pmid:10940357 |
Fukunaga T et al. | Implication of sphingolipid metabolism in the stability of the Golgi apparatus. | 2000 | J. Cell. Sci. | pmid:10954427 |
Jiang Z et al. | Ceramides induce apoptosis in HeLa cells and enhance cytochrome c-induced apoptosis in Xenopus egg extracts. | 2000 | Cell. Mol. Life Sci. | pmid:10961348 |
Di Nardo A et al. | Ceramide 2 (N-acetyl sphingosine) is associated with reduction in Bcl-2 protein levels by Western blotting and with apoptosis in cultured human keratinocytes. | 2000 | Br. J. Dermatol. | pmid:10971319 |
Menné C et al. | Ceramide-induced TCR up-regulation. | 2000 | J. Immunol. | pmid:10975817 |
Muriel MP et al. | Mitochondrial free calcium levels (Rhod-2 fluorescence) and ultrastructural alterations in neuronally differentiated PC12 cells during ceramide-dependent cell death. | 2000 | J. Comp. Neurol. | pmid:10982470 |
Pahlavani MA and Vargas DM | The effect of a ceramide analog, N-acetylsphingosine on the induction of proliferation and IL-2 synthesis in T cells from young and old F344 rats. | 2000 | Immunopharmacology | pmid:10996032 |
Hirokawa M et al. | Induction of tissue factor production but not the upregulation of adhesion molecule expression by ceramide in human vascular endothelial cells. | 2000 | Tohoku J. Exp. Med. | pmid:10997557 |
Müller-Wieprecht V et al. | Bcl-2 transfected HaCaT keratinocytes resist apoptotic signals of ceramides, tumor necrosis factor alpha and 1 alpha, 25-dihydroxyvitamin D(3). | 2000 | Arch. Dermatol. Res. | pmid:11000289 |
Klapisz E et al. | Sphingolipids and cholesterol modulate membrane susceptibility to cytosolic phospholipase A(2). | 2000 | J. Lipid Res. | pmid:11013311 |
Siskind LJ and Colombini M | The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis. | 2000 | J. Biol. Chem. | pmid:11027675 |
Sautin Y et al. | Ceramide-induced apoptosis of human thyroid cancer cells resistant to apoptosis by irradiation. | 2000 | Thyroid | pmid:11041449 |
Navarro P et al. | Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. | 2000 | Growth Horm. IGF Res. | pmid:11042022 |