N-acetylsphingosine is a lipid of Sphingolipids (SP) class. N-acetylsphingosine is associated with abnormalities such as Morphologically altered structure, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and Gigantism. The involved functions are known as inhibitors, anti-apoptosis, Apoptosis, Dephosphorylation and immunoreactivity. N-acetylsphingosine often locates in Plasma membrane, Mitochondria, Pore, Membrane and Cytoplasmic matrix. The associated genes with N-acetylsphingosine are EGR3 gene, CFB gene, FATE1 gene, P4HTM gene and PFDN4 gene. The related lipids are Sphingolipids, Cardiolipins, Glycerophospholipids, dihydroceramide and Phosphatidic Acid.
To understand associated biological information of N-acetylsphingosine, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
N-acetylsphingosine is suspected in Morphologically altered structure, protrusion, DERMATITIS HERPETIFORMIS, FAMILIAL, Atherosclerosis, Cardiovascular Diseases, Hyperinsulinism and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with N-acetylsphingosine
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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There are no associated biomedical information in the current reference collection.
Authors | Title | Published | Journal | PubMed Link |
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Verheij M et al. | Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. | 1996 | Nature | pmid:8598911 |
Nickels JT and Broach JR | A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. | 1996 | Genes Dev. | pmid:8600023 |
Welsh N | Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. | 1996 | J. Biol. Chem. | pmid:8626526 |
Wiesner DA and Dawson G | Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. | 1996 | J. Neurochem. | pmid:8627293 |
Latinis KM and Koretzky GA | Fas ligation induces apoptosis and Jun kinase activation independently of CD45 and Lck in human T cells. | 1996 | Blood | pmid:8562955 |
Abe A et al. | A novel enzyme that catalyzes the esterification of N-acetylsphingosine. Metabolism of C2-ceramides. | 1996 | J. Biol. Chem. | pmid:8662981 |
Cuvillier O et al. | Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. | 1996 | Nature | pmid:8657285 |
Degnan BM et al. | Sphingomyelinase inhibits in vitro Leydig cell function. | 1996 May-Jun | Ann. Clin. Lab. Sci. | pmid:8726216 |
Whitman SP et al. | Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation. | 1997 | J. Biol. Chem. | pmid:9295281 |
Nakabo Y and Pabst MJ | C2-ceramide and C6-ceramide inhibited priming for enhanced release of superoxide in monocytes, but had no effect on the killing of leukaemic cells by monocytes. | 1997 | Immunology | pmid:9176098 |